V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) (ETS1) ELISA Kits

Human V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) (ETS1) Interaktionspartner

1. Results found the expression pattern of ETS1 in hepatocellular carcinoma (HCCs) cell lines to be correlated with ZEB2 expression in poorly differentiated HCC cells with mesenchymal phenotype.

2. The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis

3. ETS1 up-regulates human RYBP expression at transcriptional level. ETS1 binds to RYBP promoter region through a multiple of conserved ETS1 binding sites in RYBP promoter region. RYBP is required for ETS1-induced human tumor cell growth inhibition.

4. ETS1 and SP1 regulated DHX15 expression in acute lymphoblastic leukaemia.

5. The current study demonstrates a pro-angiogenic role of Fzd5, which was shown to be involved in endothelial tubule formation, cell cycle progression and migration, and partly does so by repression of PKC/Ets1-mediated transcription of Flt1 and Angpt2.

6. FGF9-induced ovarian cancer cell invasion involves VEGFA/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming.

7. The results identify the interacting surface between Ets-1 and the two DNA-repair enzymes centered on the alpha-helix H1 of the ETS domain, leaving alpha-helix H3 available to bind DNA.

8. Study demonstrates the effect of Ets-1 in the invasion and epithelial to mesenchymal transition in the pathway of breast cancer progression, and suggests a plausible role of Ets-1 dependent regulation of MMP-9 gene which may have a significant impact on breast carcinogenesis.

9. Our results suggest that miR-326 might promote B cells differentiation by targeting Ets-1, a negative regulator of B cells differentiation and therefore participate in the pathogenesis of systemic lupus erythematosus.

10. Study reveal that ETS1 polymorphisms are associated with IIMs alone and IIMs with ILD in a northern Chinese Han population.

11. ETS1 knockdown simulated the inhibitory effects of the overexpression of miR766 on PDAC cells.

12. ilencing endogenous Ets1 by siRNA in mouse cell lines decreases Twist1 mRNA levels, decreases invasion, and increases cell growth. Ets1 and Twist1 are at the crossroad of several signaling pathways in cancer. Understanding their regulation may inform the development of therapies to impair lung tumor metastasis.

13. Overexpression of ETS-1 accelerates the metabolic clearance of Sorafenib in hepatocellular carcinoma and leads to the better survival and faster migration of those cells. ETS-1 could enhance the activation of PXR and be a potential therapeutic target for overcoming Sorafenib resistance in hepatocellular carcinoma treatment.

14. Reciprocal regulatory interactions between miR-139-5p and ETS1 modulate aerobic glycolysis, proliferation, and metastasis in hepatocellular carcinoma (HCC) cells, suggesting new targets for HCC treatment.

15. Study demonstrates that Ets-1 overexpression in breast cancer cells promotes their adhesion to endothelial cells and invasion.

16. lncRNA pancEts-1 exhibits oncogenic properties that drive the progression of gastric cancer via regulating the NONO/ERG/Ets-1 axis.

17. ETS1 protein expression was also shown to be highly increased in UT-7 cells expressing BCR-ABL either constitutively or under the control of TET-inducible promoters.A significant increase of ETS1 messenger RNA (mRNA) expression was observed in blood cells from CML patients at diagnosis. The ETS1 transcriptional program correlates with progression toward blast crisis.

18. the mutant TERT promoter is reactivated by cooperative binding of p52 and ETS1

19. enhanced ETS factor activity and the transcription of ETS family target genes related to spliceosome function and cell death induction via alternate MCL1 splicing, is reported.

20. ETS1 protein renders its DNA binding targets extremely susceptible to ultraviolet damage in vitro.

Mouse (Murine) V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) (ETS1) Interaktionspartner

1. Ets-1 transcription factor (Ets1) deletion in T cells induces systemic lupus erythematosus (SLE)-like autoimmunity in mice.

2. Findings support the notion of a targeting mechanism for the selective diversification of antibody genes with limited genome wide mutagenesis by recruitment of Activation-induced cytidine deaminase by PAX5 and ETS1 in a transcription factor complex.

3. miR-326 may target the Ets-1 protein to contribute to iodide-induced thyroiditis, providing a new theoretical basis for the use of miRNA targeting therapy for the treatment of autoimmune diseases.

4. endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF

5. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

6. Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.

7. data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development.

8. Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes.

9. reduced lung levels of PPARgamma and increased levels of microRNA-27a (miR-27a), v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS1), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 and E selectin).

10. the affinities of two sequence-divergent ETS homologs, PU.1 and Ets-1, to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.

11. data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA

12. Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes.

13. Akt2 upregulates dendritic cell migration at least in part by ETS1-dependent stimulation of IP3R2 transcription.

14. The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1.

15. Ets1 and Sox10 interact to promote proper melanocyte and enteric ganglia development from the neural crest.

16. our data suggested that ESE1/ELF3 may promote the UC progression via accelerating NF-kappaB activation and thus facilitating IEC apoptosis.

17. maintenance of appropriate c-ets-1 levels is essential to prevent loss of self-tolerance in the B cell compartment.

18. Data indicate interactions between Ets1 transcription factor and two of its important regulators: Lyn, which maintains Ets1 expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk.

19. our results demonstrate that both Ets1 and miR-155 can directly regulate the expression of CD1d on B-cells

20. Data suggest that the long-term effect of curcumin may attenuate cancer progression via the down-regulation of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) modulated by E26 transformation-specific protein (ETS) and nuclear factor-kappaB (NF-kappaB).

Cow (Bovine) V-Ets erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) (ETS1) Interaktionspartner

1. The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites.

2. Ets-1 up-regulation is involved in the development of retinal neovascularization.