Uroplakin 2 Proteine (UPK2)

UPK2 encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. Zusätzlich bieten wir Ihnen Uroplakin 2 Antikörper (23) und Uroplakin 2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
UPK2 7379 O00526
Maus UPK2 UPK2 22269  
Ratte UPK2 UPK2 689093  
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Showing 6 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 bis 55 Tage
$7,294.44
Details
Human Cells Human His tag   50 μg 4 Days
$377.30
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human UPK2 Protein. 100 μg 11 bis 18 Tage
$534.65
Details
Human Cells Human His tag   10 μg 15 bis 16 Tage
$300.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 bis 19 Tage
$553.85
Details

UPK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Weitere Proteine zu Uroplakin 2 (UPK2) Interaktionspartnern

Human Uroplakin 2 (UPK2) Interaktionspartner

  1. Uroplakin II was immunopositive in 53% and 60% of urothelial carcinomas (UC) of the bladder and the ureter, respectively.

  2. These results suggest that whereas GATA-3 and uroplakin II may be most useful in the diagnosis of urothelial carcinoma metastasis, p40 may be additionally suited as a prognostic marker.

  3. UPII, GATA3, and p40, when used in combination, are highly sensitive in the differential diagnosis of invasive urothelial carcinoma.

  4. UPII was highly specific/moderately sensitive for urothelial carcinoma. May be a potentially useful marker to identify urothelial lineage and help distinguish UC from prostate cancer or, in conjunction with GATA3, from metastatic breast cancer.

  5. UPII demonstrates a significantly higher sensitivity than UPIII in conventional and variant urothelial carcinomas

  6. Uroplakin II antibody BC21 demonstrated superior sensitivity and specificity in urothelial carcinoma, compared with uroplakin III, suggesting an advantage in differential diagnosis of urothelial carcinoma and in the detection of tumors of unknown origin.

  7. combination of prostate stem cell antigen enhancer and uroplakin II promoter is feasible in constructing bladder cancer-specific vectors

  8. study offers no definitive support for uroplakin II mutations causing human renal tract malformations

Mouse (Murine) Uroplakin 2 (UPK2) Interaktionspartner

  1. Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues.

  2. role of uroplakins in CO2 transport through urothelium

  3. The despites a lower level of expression, UPII maintain its plaque association in urothelial preneoplastic lesions.

  4. Bladder-specific autoimmune response sufficient to induce inflammation and interstitial cystitis occurs in mice following immunization with recombinant murine UPK2.

  5. structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography

  6. The UPII knockout abolished plaque formation, indicating that both uroplakin heterodimers (UPIa/II and UPIb/III or IIIb) are required for plaque assembly.

Pig (Porcine) Uroplakin 2 (UPK2) Interaktionspartner

  1. HNF4 positively regulates pUPII gene promoter activity.

  2. all the major trans-regulatory elements required for bladder- and urethra-specific transcription are located in the 8.8 kb promoter upstream region

Uroplakin 2 (UPK2) Protein Überblick

Protein Überblick

This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.

Genbezeichner und Symbole assoziert mit Uroplakin 2 Proteine (UPK2)

  • uroplakin 2 (UPK2)
  • uroplakin 2 (upk2)
  • uroplakin 2 (Upk2)
  • AW491716 Protein
  • UP2 Protein
  • UPII Protein
  • UPK2 Protein

Bezeichner auf Proteinebene für Uroplakin 2 Proteine (UPK2)

uroplakin 2 , uroplakin II , uroplakin-2 , UP2 , UPII

GENE ID SPEZIES
610673 Canis lupus familiaris
707184 Macaca mulatta
100216448 Xenopus (Silurana) tropicalis
7379 Homo sapiens
22269 Mus musculus
689093 Rattus norvegicus
281569 Bos taurus
397075 Sus scrofa
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