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UNC119 is specifically expressed in the photoreceptors in the retina. Zusätzlich bieten wir Ihnen UNC119 Antikörper (18) und und viele weitere Produktgruppen zu diesem Protein an.
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Interaction of transducin (zeige GNAT1 Proteine) with uncoordinated 119 protein (UNC119): implications for the model of transducin (zeige GNAT1 Proteine) trafficking in rod photoreceptors.
Knockout of Unc119 partially reversed the transport defect of GRK1 (zeige GRK1 Proteine) in cone photoreceptors caused by deletion of Pde6d (zeige PDE6D Proteine).
Unc119 has a critical role in the development of airway inflammation, mucus prod (zeige HAND1 Proteine)uction, and bronchial hyperreactivity in a mouse model of experimental asthma.
Unc119 is a receptor-associated activator of Src (zeige SRC Proteine)-type kinases.
The results support a novel mechanism of retinal degeneration in which preapoptotic degeneration starts in the photoreceptor synapse because of a deficiency in ANT-1 (zeige SLC25A4 Proteine) and spreads to the secondary neuron transsynaptically, followed by apoptosis.
Unc119 plays an important role in fibrotic processes through myofibroblast differentiation; Unc119 increases the kinase activity of Fyn (zeige FYN Proteine) and associates with it in coprecipitation and colocalization studies.
This study provides evidence for the interaction of CaBP4 (zeige CABP4 Proteine) with Unc119 at the photoreceptor synapse.
Unc119 orchestrates the recruitment of the actin-based motor protein, myosin 5B, and the organization of multiprotein complexes on endosomes. The Unc119-regulated pathway is essential for immunological synapse formation and T cell activation.
This review will outline the trafficking pathways required for constructing the cilium by highlighting UNC119's role and the complexities involved in ciliary trafficking. Finally, despite important roles for UNC119 in cilia, UNC119 proteins also interact with non-ciliary proteins to affect other cellular processes.
Data show that the solubilising factor UNC119 sequesters myristoylated Src (zeige SRC Proteine) family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction.
Studies indicate that the binding of UNC119 and PDE6D (zeige PDE6D Proteine), to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein (zeige RAC2 Proteine) Arl3 in a GTP (zeige AK3 Proteine)-dependent manner.
Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2 (zeige ARL2 Proteine)/3.
UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.
The profile of UNC119a subcellular distribution remained largely unchanged under all tested conditions of illumination, and correlated with the profile of Galpha(t1 (zeige GNAT1 Proteine)) following its light-dependent translocation.
The discovery of the UNC119 defect provides a molecular mechanism for a subset of patients with this previously unexplained disease. Here we review our recent findings on the UNC119 mutation in ICL.
Crystal structures of Arl3 in complex with UNC119a reveal the molecular basis of specificity. The N-terminal amphipathic helix of Arl3.GppNHp is not displaced by the interswitch toggle but remains bound on the surface of the protein
This study demonistrated that UNC119 is a Galpha subunit cofactor essential for G protein trafficking in sensory cilia.
This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.
, unc-119 homolog (C. elegans)
, protein unc-119 homolog A
, retinal gene 4
, retinal protein 4
, unc-119 homolog 2
, unc-119 homolog b
, unc-119-like protein 2
, POC7 centriolar protein homolog A
, flagellar protein UNC119