Unc-119 Homolog (C. Elegans) Proteine (UNC119)

UNC119 is specifically expressed in the photoreceptors in the retina. Zusätzlich bieten wir Ihnen UNC119 Antikörper (19) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus UNC119 UNC119 22248 Q9Z2R6
UNC119 9094 Q13432
Ratte UNC119 UNC119 29402 Q62885
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Top UNC119 Proteine auf antikoerper-online.de

Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,610.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,610.67
Details

UNC119 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Unc-119 Homolog (C. Elegans) (UNC119) Interaktionspartnern

Cow (Bovine) Unc-119 Homolog (C. Elegans) (UNC119) Interaktionspartner

  1. Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.

Mouse (Murine) Unc-119 Homolog (C. Elegans) (UNC119) Interaktionspartner

  1. Knockout of Unc119 partially reversed the transport defect of GRK1 in cone photoreceptors caused by deletion of Pde6d.

  2. Unc119 has a critical role in the development of airway inflammation, mucus production, and bronchial hyperreactivity in a mouse model of experimental asthma.

  3. Unc119 is a receptor-associated activator of Src-type kinases.

  4. The results support a novel mechanism of retinal degeneration in which preapoptotic degeneration starts in the photoreceptor synapse because of a deficiency in ANT-1 and spreads to the secondary neuron transsynaptically, followed by apoptosis.

  5. Unc119 plays an important role in fibrotic processes through myofibroblast differentiation; Unc119 increases the kinase activity of Fyn and associates with it in coprecipitation and colocalization studies.

  6. This study provides evidence for the interaction of CaBP4 with Unc119 at the photoreceptor synapse.

  7. Unc119 orchestrates the recruitment of the actin-based motor protein, myosin 5B, and the organization of multiprotein complexes on endosomes. The Unc119-regulated pathway is essential for immunological synapse formation and T cell activation.

Human Unc-119 Homolog (C. Elegans) (UNC119) Interaktionspartner

  1. UNC119 was significantly up-regulated in liver cancer cells and tissues. It promoted cell growth and migration through the Wnt/beta-catenin and TGF-beta/EMT signaling pathways, respectively

  2. The findings support that UNC119 is a regulator of the RASSF6-MDM2-p53 axis and functions as a tumor suppressor.

  3. This review will outline the trafficking pathways required for constructing the cilium by highlighting UNC119's role and the complexities involved in ciliary trafficking. Finally, despite important roles for UNC119 in cilia, UNC119 proteins also interact with non-ciliary proteins to affect other cellular processes.

  4. Data show that the solubilising factor UNC119 sequesters myristoylated Src family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction.

  5. Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner.

  6. Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.

  7. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.

  8. The profile of UNC119a subcellular distribution remained largely unchanged under all tested conditions of illumination, and correlated with the profile of Galpha(t1) following its light-dependent translocation.

  9. The discovery of the UNC119 defect provides a molecular mechanism for a subset of patients with this previously unexplained disease. Here we review our recent findings on the UNC119 mutation in ICL.

  10. Crystal structures of Arl3 in complex with UNC119a reveal the molecular basis of specificity. The N-terminal amphipathic helix of Arl3.GppNHp is not displaced by the interswitch toggle but remains bound on the surface of the protein

  11. Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.

  12. This study demonistrated that UNC119 is a Galpha subunit cofactor essential for G protein trafficking in sensory cilia.

  13. Heightened expression of Unc119 promotes T helper type (Th)2 cells, inhibits Th1 cell differentiation, and contributes to the pathogenesis of asthma in humans.

  14. identification as activator of SRC-type tyrosine kinases

  15. The presence of ARL2 in the retina and co-localization with HRG4 was confirmed. Amino acid residues of PDEdelta involved in binding ARL2 and forming a hydrophobic pocket were shown to be highly conserved in HRG4

  16. Unc119 plays an important role in fibrotic processes through myofibroblast differentiation; Unc119 increases the kinase activity of Fyn and associates with it in coprecipitation and colocalization studies.

  17. Unc119 orchestrates the recruitment of the actin-based motor protein, myosin 5B, and the organization of multiprotein complexes on endosomes. The Unc119-regulated pathway is essential for immunological synapse formation and T cell activation.

  18. demonstrate a role for Unc119 in clathrin- and caveolae-based endocytosis as well as macropinocytosis. Depletion of Unc119 in fibroblasts increases FM4-64, albumin, viruses, and ligand-coated beads.

UNC119 Protein Überblick

Protein Überblick

This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit UNC119

  • unc-119 lipid binding chaperone (unc119)
  • unc-119 lipid binding chaperone (UNC119)
  • unc-119 lipid binding chaperone (Unc119)
  • unc-119 homolog b (C. elegans) (unc119b)
  • CG1659 gene product from transcript CG1659-RC (unc-119)
  • flagellar protein UNC119 (UNC119)
  • unc-119 homolog (un119)
  • anon-EST:Posey123 Protein
  • CG1659 Protein
  • D11Bhm52 Protein
  • DmelCG1659 Protein
  • dm unc-119 Protein
  • HRG4 Protein
  • MRG4 Protein
  • POC7 Protein
  • POC7A Protein
  • Rg4 Protein
  • RRG4 Protein
  • Rtg4 Protein
  • Unc-119 Protein
  • Unc119 Protein
  • unc119.2 Protein
  • Unc119h Protein
  • Uncl19 Protein
  • zgc:136476 Protein

Bezeichner auf Proteinebene für UNC119

unc-119 homolog , unc-119 homolog (C. elegans) , protein unc-119 homolog A , retinal gene 4 , retinal protein 4 , unc-119 homolog 2 , unc-119 homolog b , unc-119-like protein 2 , POC7 centriolar protein homolog A , unc-119 , CG1659-PA , unc-119-PA , flagellar protein UNC119

GENE ID SPEZIES
100127819 Xenopus (Silurana) tropicalis
455028 Pan troglodytes
538501 Bos taurus
491169 Canis lupus familiaris
22248 Mus musculus
678653 Danio rerio
9094 Homo sapiens
29402 Rattus norvegicus
31664 Drosophila melanogaster
771690 Gallus gallus
9622771 Volvox carteri f. nagariensis
100380832 Salmo salar
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