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TSSC1 has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Zusätzlich bieten wir Ihnen TSSC1 Antikörper (48) und viele weitere Produktgruppen zu diesem Protein an.
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Fluorescence recovery after photobleaching shows that TSSC1 is required for efficient recruitment of GARP (zeige CNGB1 Proteine) to the TGN (zeige TG Proteine). These studies thus demonstrate that TSSC1 plays a critical role in endosomal retrieval pathways as a regulator of both GARP (zeige CNGB1 Proteine) and EARP function.
TSSC1 inhibits breast c (zeige RUNX2 Proteine)ancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2.
Overexpression of Runx2 (zeige RUNX2 Proteine) induces bone osteolysis in a TSSC1-dependent manner.
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11.
tumor suppressing subtransferable candidate 1
, protein TSSC1
, protein TSSC1-like
, tumor-suppressing STF cDNA 1 protein
, tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein