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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Zusätzlich bieten wir Ihnen Ubiquitin-Conjugating Enzyme E2A Antikörper (58) und Ubiquitin-Conjugating Enzyme E2A Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 (zeige ALDH1A1 Proteine) and SOX2 (zeige SOX2 Proteine) and poor prognosis of OC patients.
RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 (zeige PSMF1 Proteine) and the lamin B receptor (zeige LBR Proteine).
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.
This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (zeige CBX5 Proteine) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.
RNF168 (zeige RNF168 Proteine), in complex with RAD6A or RAD6B (zeige UBE2B Proteine), is activated in the DNA-damage-induced protein ubiquitination cascade.
RAD6A is a regulator of Parkin (zeige PARK2 Proteine)-dependent mitophagy plays a critical role in maintaining neuronal function.
UBE2A specifically interacts with CDK9 (zeige CDK9 Proteine), but not CDK2 (zeige CDK2 Proteine) and is phosphorylated by CDK9 (zeige CDK9 Proteine) in vitro.
results indicate a causal role of UBE2A in learning and mGLUR (zeige GRM8 Proteine)-dependent long-term depression
Disruption of pre-TCR expression accelerates lymphomagenesis in E2A (zeige TCF3 Proteine)-deficient mice.
signaling through Notch (zeige NOTCH1 Proteine) modulates the turnover of E2A (zeige TCF3 Proteine) proteins
absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2 A
, ubiquitin-conjugating enzyme E2A (RAD6 homolog)
, ubiquitin-conjugating enzyme E2A
, RAD6 homolog A
, ubiquitin carrier protein A
, ubiquitin-protein ligase A
, ubiquitin-conjugating enzyme E2A, RAD6 homolog
, ubiquitin-conjugating enzyme HR6A