Ubiquitin-Conjugating Enzyme E2A Proteine (ube2a)

Human Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaktionspartner

1. As confirmed by deep sequencing, the c.330G>A substitution in UBE2A was undetectable in genomic DNA from maternal blood cells, suggesting that the recurrent UBE2A deficiency observed in males of this family is caused by a maternal germline mosaicism.

2. RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients.

3. RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor.

4. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.

5. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.

6. This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.

7. RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway

8. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.

9. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

10. RAD6A is a regulator of Parkin-dependent mitophagy plays a critical role in maintaining neuronal function.

11. UBE2A specifically interacts with CDK9, but not CDK2 and is phosphorylated by CDK9 in vitro.

12. RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53.

13. UBE2A deficiency syndrome is reported in two male patients.

14. showed that the function of FA signaling pathway is at least partly mediated through coupling with hRad6/hRad18 signaling (HHR6 pathway)

15. Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome

16. high resolution backbone structure from nmr

17. A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease.

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaktionspartner

1. results indicate a causal role of UBE2A in learning and mGLUR-dependent long-term depression

2. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

3. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.

4. signaling through Notch modulates the turnover of E2A proteins

5. absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage