Ubiquitin-Conjugating Enzyme E2A Proteine (ube2a)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Zusätzlich bieten wir Ihnen Ubiquitin-Conjugating Enzyme E2A Antikörper (58) und Ubiquitin-Conjugating Enzyme E2A Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ube2a 7319 P49459
ube2a 22209 Q9Z255
Ratte ube2a ube2a 298317  
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Top Ubiquitin-Conjugating Enzyme E2A Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human GST tag,His tag   50 μg Anmelden zum Anzeigen 4 Days
$121.00
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 4 bis 8 Tage
$394.90
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$194.76
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$3,055.38
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Escherichia coli (E. coli) Human GST tag,His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$100.00
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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ube2a Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaktionspartnern

Human Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaktionspartner

  1. As confirmed by deep sequencing, the c.330G>A substitution in UBE2A was undetectable in genomic DNA from maternal blood cells, suggesting that the recurrent UBE2A deficiency observed in males of this family is caused by a maternal germline mosaicism.

  2. RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients.

  3. RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor.

  4. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.

  5. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.

  6. This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A.

  7. RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway

  8. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.

  9. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

  10. RAD6A is a regulator of Parkin-dependent mitophagy plays a critical role in maintaining neuronal function.

  11. UBE2A specifically interacts with CDK9, but not CDK2 and is phosphorylated by CDK9 in vitro.

  12. RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53.

  13. UBE2A deficiency syndrome is reported in two male patients.

  14. showed that the function of FA signaling pathway is at least partly mediated through coupling with hRad6/hRad18 signaling (HHR6 pathway)

  15. Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome

  16. high resolution backbone structure from nmr

  17. A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease.

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2A (ube2a) Interaktionspartner

  1. results indicate a causal role of UBE2A in learning and mGLUR-dependent long-term depression

  2. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.

  3. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice.

  4. signaling through Notch modulates the turnover of E2A proteins

  5. absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage

Ubiquitin-Conjugating Enzyme E2A (ube2a) Protein Überblick

Protein Überblick

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Genbezeichner und Symbole assoziert mit ube2a

  • ubiquitin conjugating enzyme E2 A (UBE2A)
  • ubiquitin conjugating enzyme E2 A L homeolog (ube2a.L)
  • ubiquitin conjugating enzyme E2 A (ube2a)
  • ubiquitin-conjugating enzyme E2A (RAD6 homolog) (ube2a)
  • ubiquitin-conjugating enzyme E2A (Ube2a)
  • BHR6A Protein
  • HHR6A Protein
  • HR6A Protein
  • Mhr6a Protein
  • mp:zf637-2-000771 Protein
  • MRXS30 Protein
  • MRXSN Protein
  • RAD6A Protein
  • si:bz46j2.4 Protein
  • UBC2 Protein
  • wu:fa01h11 Protein

Bezeichner auf Proteinebene für ube2a

ubiquitin-conjugating enzyme E2 A , ubiquitin-conjugating enzyme E2A (RAD6 homolog) , ubiquitin-conjugating enzyme E2A , RAD6 homolog A , ubiquitin carrier protein A , ubiquitin-protein ligase A , ubiquitin-conjugating enzyme E2A, RAD6 homolog , ubiquitin-conjugating enzyme HR6A

GENE ID SPEZIES
282107 Bos taurus
398788 Xenopus laevis
448176 Xenopus (Silurana) tropicalis
492095 Canis lupus familiaris
693716 Macaca mulatta
737175 Pan troglodytes
797853 Danio rerio
100058679 Equus caballus
100195873 Salmo salar
100217902 Taeniopygia guttata
7319 Homo sapiens
22209 Mus musculus
298317 Rattus norvegicus
100154142 Sus scrofa
395672 Gallus gallus
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