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Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. Zusätzlich bieten wir Ihnen USP46 Antikörper (26) und und viele weitere Produktgruppen zu diesem Protein an.
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we identified USP12 and USP46 as histone H2A and H2B deubiquitinases that regulate Xenopus development
The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers.
Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation.
USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt.
results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population.
These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.
two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1
Usp46 mutation is associated with Impaired Maternal Behavior.
Usp46 regulates a wide range of behavioral phenotypes that might be related to mental disorders
results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004
ubiquitin carboxyl-terminal hydrolase 46
, ubiquitin specific protease 46
, deubiquitinating enzyme 46
, ubiquitin thioesterase 46
, ubiquitin thiolesterase 46
, ubiquitin-specific-processing protease 46
, ubiquitin specific peptidase 46