Ubiquitin Specific Peptidase 4 Proteine (USP4)

Human Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

1. Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues.

2. The data indicate that USP4 interacts with and deubiquitinates IRF4 (zeige IRF4 Proteine), and also stabilizes IRF4 (zeige IRF4 Proteine) protein and promotes IRF4 (zeige IRF4 Proteine) function to facilitate IL-4 (zeige IL4 Proteine) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.

3. These results identify USP4 as a novel regulator of Dvl (zeige DVL2 Proteine) in Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal and show its involvement in Wnt3a (zeige WNT3A Proteine)-induced osteoblast differentiation

4. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8 (zeige IRF8 Proteine)) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 (zeige IRF8 Proteine) protein levels in regulatory T-lymphocytes; USP4 and IRF8 (zeige IRF8 Proteine) are also expressed in helper T-lymphocytes.

5. USP4 inhibits p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) through deubiquitinating and stabilizing HDAC2 (zeige HDAC2 Proteine)

6. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1 (zeige RNPS1 Proteine).

7. Data indicate that programmed cell death 4 (PDCD4 (zeige PDCD4 Proteine)) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.

8. Ubiquitin-specific protease 4 (USP4), recently identified as a beta (zeige SUCLA2 Proteine)-catenin (zeige CTNNB1 Proteine)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (zeige CTNNB1 Proteine) protein.

9. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

10. USP4 cooperates with CtIP (zeige RBBP8 Proteine) in DNA double-strand break end resection.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

1. In this study, we identified ubiquitin-specific protease 4 (USP4), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 enhances myogenesis by controlling MyoD (zeige MYOD1 Proteine) and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner

2. The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (zeige SMAD4 Proteine).

3. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

4. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (zeige TGFB1 Proteine) type I receptor (zeige TGFBR1 Proteine) and AKT (zeige AKT1 Proteine) signalling pathways.

5. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (zeige TP53 Proteine) levels.

6. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.