Ubiquitin Specific Peptidase 4 Proteine (USP4)

The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Zusätzlich bieten wir Ihnen USP4 Antikörper (118) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP4 7375 Q13107
Maus USP4 USP4 22258 P35123
Ratte USP4 USP4 290864 B2GUZ1
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar

USP4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Am meisten referenzierte USP4 Proteine

  1. Human USP4 Protein expressed in Wheat germ - ABIN1324801 : Zhang, Berger, Yang, Lu: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. in The EMBO journal 2011 (PubMed)

Weitere Proteine zu Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartnern

Human Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

  1. Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues.

  2. The data indicate that USP4 interacts with and deubiquitinates IRF4 (zeige IRF4 Proteine), and also stabilizes IRF4 (zeige IRF4 Proteine) protein and promotes IRF4 (zeige IRF4 Proteine) function to facilitate IL-4 (zeige IL4 Proteine) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.

  3. These results identify USP4 as a novel regulator of Dvl (zeige DVL2 Proteine) in Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal and show its involvement in Wnt3a (zeige WNT3A Proteine)-induced osteoblast differentiation

  4. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8 (zeige IRF8 Proteine)) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 (zeige IRF8 Proteine) protein levels in regulatory T-lymphocytes; USP4 and IRF8 (zeige IRF8 Proteine) are also expressed in helper T-lymphocytes.

  5. USP4 inhibits p53 (zeige TP53 Proteine) and NF-kappaB (zeige NFKB1 Proteine) through deubiquitinating and stabilizing HDAC2 (zeige HDAC2 Proteine)

  6. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1 (zeige RNPS1 Proteine).

  7. Data indicate that programmed cell death 4 (PDCD4 (zeige PDCD4 Proteine)) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.

  8. Ubiquitin-specific protease 4 (USP4), recently identified as a beta (zeige SUCLA2 Proteine)-catenin (zeige CTNNB1 Proteine)-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin (zeige CTNNB1 Proteine) protein.

  9. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

  10. USP4 cooperates with CtIP (zeige RBBP8 Proteine) in DNA double-strand break end resection.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

  1. In this study, we identified ubiquitin-specific protease 4 (USP4), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 enhances myogenesis by controlling MyoD (zeige MYOD1 Proteine) and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner

  2. The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (zeige SMAD4 Proteine).

  3. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

  4. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta (zeige TGFB1 Proteine) type I receptor (zeige TGFBR1 Proteine) and AKT (zeige AKT1 Proteine) signalling pathways.

  5. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 (zeige TP53 Proteine) levels.

  6. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.

USP4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit USP4

  • ubiquitin specific peptidase 4 (USP4)
  • ubiquitin specific peptidase 4 (proto-oncogene) (Usp4)
  • ubiquitin specific peptidase 4 (Usp4)
  • F730026I20Rik Protein
  • mKIAA4155 Protein
  • Unp Protein
  • Unph Protein

Bezeichner auf Proteinebene für USP4

ubiquitin specific protease 4 , deubiquitinating enzyme 4 , ubiquitin carboxyl-terminal esterase 4 , ubiquitin carboxyl-terminal hydrolase 4 , ubiquitin specific protease 4 (proto-oncogene) , ubiquitin thioesterase 4 , ubiquitin thiolesterase 4 , ubiquitin-specific processing protease 4 , ubiquitous nuclear protein homolog , ubiquitin-specific-processing protease 4 , ubiquitous nuclear protein

100228772 Taeniopygia guttata
7375 Homo sapiens
22258 Mus musculus
290864 Rattus norvegicus
508042 Bos taurus
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