Ubiquitin Specific Peptidase 4 Proteine (USP4)

The protein encoded by USP4 is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Zusätzlich bieten wir Ihnen USP4 Antikörper (115) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP4 7375 Q13107
Maus USP4 USP4 22258 P35123
Ratte USP4 USP4 290864 B2GUZ1
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days

USP4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Am meisten referenzierte USP4 Proteine

  1. Human USP4 Protein expressed in Wheat germ - ABIN1324801 : Zhang, Berger, Yang, Lu: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. in The EMBO journal 2011 (PubMed)

Weitere Proteine zu Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartnern

Human Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

  1. USP4 expression was significantly down-regulated in lung adenocarcinoma. USP4 expression might be a favorable biomarker in terms of overall survival and recurrence-free survival in the lung adenocarcinoma patients.

  2. We show here that mutating the active site cysteine of human USP4 and yeast Ubp8 to alanine increases the affinity of the DUB for mono- or diubiquitin by 10-150-fold.

  3. Study provide a novel mechanistic insight into the growth-regulatory role of TRPS1-USP4-HDAC2 axis by providing evidence that TRPS1 recruits USP4 to deubiquitinate and stabilize HDAC2. This is the first example of the non-transcription factor function of GATA transcription factor which affects the ubiquitination and transcription repressive function of HDAC2, acetylation of H4K16, and the deubiquitinase function of USP4.

  4. Data showed significantly increased expression of USP4 in cancer tissues compared to that in para-carcinoma tissues.

  5. The data indicate that USP4 interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.

  6. These results identify USP4 as a novel regulator of Dvl in Wnt/beta-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation

  7. Data suggest that ubiquitin specific protease 4 (USP4) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 and IRF8 are also expressed in helper T-lymphocytes.

  8. USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2

  9. ubiquitin-specific protease 4 (USP4) is a binding partner of RNPS1.

  10. Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4), which plays a role as a tumor suppressor.

  11. Ubiquitin-specific protease 4 (USP4), recently identified as a beta-catenin-specific deubiquitinylating enzyme, was highly expressed in PC14PE6/LvBr4 cells and involved in the increased stability of beta-catenin protein.

  12. USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.

  13. USP4 cooperates with CtIP in DNA double-strand break end resection.

  14. Results demonstrate that aberrant expression of USP4 contributes to the development and progression of colorectal cancer and reveal a critical mechanism underlying USP4-mediated oncogenic activity.

  15. findings thus identify USP4 as a novel DNA repair regulator and invoke a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

  16. USP4 requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover by promoting ubiquitin exchange.

  17. USP4 and IL-17 mRNA, but not RORgammat mRNA, were significantly elevated in CD4(+) T cells from patients with rheumatic heart disease

  18. USP4 overexpression is associated with hepatocellular carcinoma.

  19. Authors identified USP4 as a new positive regulator for RIG-I that acts through deubiquitinating K48-linked ubiquitin chains and stabilizing RIG-I.

  20. Data suggest that USP4 down-regulates RIP1 (receptor-interacting serine-threonine kinase 1)-mediated TNFalpha (tumor necrosis factor-alpha) activation and promotes TNFalpha-induced apoptosis via deubiquitination of RIP1 in head/neck carcinoma.

Mouse (Murine) Ubiquitin Specific Peptidase 4 (USP4) Interaktionspartner

  1. In this study, we identified ubiquitin-specific protease 4 (USP4), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 enhances myogenesis by controlling MyoD and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner

  2. The authors demonstrated that ubiquitin-specific protease (USP) 4 strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  3. USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response

  4. Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta type I receptor and AKT signalling pathways.

  5. USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels.

  6. the existence of a nuclear export signal ((133)VEVYLLELKL(142)) in Usp4;Usp4 is thus the first oncogenic deubiquitylating enzyme reported to have nucleocytoplasmic shuttling properties.

USP4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit USP4

  • ubiquitin specific peptidase 4 (USP4)
  • ubiquitin specific peptidase 4 (proto-oncogene) (Usp4)
  • ubiquitin specific peptidase 4 (Usp4)
  • F730026I20Rik Protein
  • mKIAA4155 Protein
  • Unp Protein
  • Unph Protein

Bezeichner auf Proteinebene für USP4

ubiquitin specific protease 4 , deubiquitinating enzyme 4 , ubiquitin carboxyl-terminal esterase 4 , ubiquitin carboxyl-terminal hydrolase 4 , ubiquitin specific protease 4 (proto-oncogene) , ubiquitin thioesterase 4 , ubiquitin thiolesterase 4 , ubiquitin-specific processing protease 4 , ubiquitous nuclear protein homolog , ubiquitin-specific-processing protease 4 , ubiquitous nuclear protein

100228772 Taeniopygia guttata
7375 Homo sapiens
22258 Mus musculus
290864 Rattus norvegicus
508042 Bos taurus
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