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Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Zusätzlich bieten wir Ihnen USP22 Antikörper (94) und und viele weitere Produktgruppen zu diesem Protein an.
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USP22 played an important role in retinoblastoma cell proliferation/aging and apoptosis.
indicate USP22 as a novel deubiquitinase of BMI1 (zeige BMI1 Proteine) in glioma
USP22 mediates CRC (zeige CALR Proteine) cell chemoresistance through the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway and that reducing USP22 in CRC (zeige CALR Proteine) cells diminishes chemoresistance.
Data provided evidence that USP22, an up-stream molecule of AP4 (zeige REPIN1 Proteine), exhibits strong potential to promote colorectal cancer (CRC (zeige CALR Proteine)) metastasis, particularly CRC (zeige CALR Proteine) migration and invasion capacities, both in vitro and in vivo, by inducing EMT (zeige ITK Proteine) via AP4 (zeige REPIN1 Proteine) activating. Moreover, USP22 and AP4 (zeige REPIN1 Proteine) overexpression may stimulate tumor metastasis and adversely affect overall survival in CRC (zeige CALR Proteine) patients.
Cancer stem cells marker USP22 influences drug sensitivity via regulating SIRT1 (zeige SIRT1 Proteine), which will shed new insights into the mechanisms of multidrug resistance in hepatocellular carcinoma .
our study demonstrates that USP22 is indispensable for gastric cancer stem cell self-renewal through stabilization of BMI1 (zeige BMI1 Proteine).
Downregulation of USP22 in ATC (zeige SRPK1 Proteine) cells impeded tumor growth and lung metastasis in vivo.
Studies indicate that aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis.
we demonstrated that USP22 was highly expressed in OS tissues and cells lines. Downregulation of USP22 inhibited OS cell proliferation, invasion, and EMT (zeige ITK Proteine) in vitro. In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo.
In breast cancer cell lines USP22 increases c-Myc (zeige MYC Proteine) stability through c-Myc (zeige MYC Proteine) deubiquitination, which is closely correlated with breast cancer progression.
Usp22 is the first deubiquitinase reported to regulate both V(D)J recombination and class switch recombination in vivo by facilitating classical non-homologous end joining.
high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.
that nuclear GSK3beta- and USP22-mediated KDM1A (zeige KDM1A Proteine) stabilization is essential for glioblastoma tumorigenesis
Usp22 deficiency impairs intestinal epithelial lineage specification.
USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2 (zeige SOX2 Proteine)) in embryonic stem cells.
Genetic deletion of the usp22 gene results in Sirt1 (zeige SIRT1 Proteine) instability, elevated p53 (zeige TP53 Proteine) transcriptional activity and early embryonic lethality.
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
deubiquitinating enzyme 22
, ubiquitin carboxyl-terminal hydrolase 22
, ubiquitin specific protease 22
, ubiquitin thioesterase 22
, ubiquitin thiolesterase 22
, ubiquitin-specific processing protease 22
, ubiquitin-specific-processing protease 22
, ubiquitin specific peptidase 22
, ubiquitin carboxyl-terminal hydrolase 22-like
, Deubiquitinating enzyme 22-B
, Ubiquitin thioesterase 22-B
, Ubiquitin-specific-processing protease 22-B
, deubiquitinating enzyme 22 B
, ubiquitin carboxyl-terminal hydrolase 22-B
, ubiquitin specific peptidase 22 b
, ubiquitin thioesterase 22 B
, ubiquitin thiolesterase 22-B
, ubiquitin-specific-processing protease 22 B