Ubiquitin Specific Peptidase 22 Proteine (USP22)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Zusätzlich bieten wir Ihnen USP22 Antikörper (94) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP22 23326 Q9UPT9
USP22 216825 Q5DU02
Ratte USP22 USP22 303201  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insect cells (Sf21) Human His tag   50 μg Anmelden zum Anzeigen 5 bis 8 Tage

USP22 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,

Mouse (Murine)

Weitere Proteine zu Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartnern

Human Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartner

  1. USP22 and CCND1 (zeige CCND1 Proteine) levels correlate in patient lung and colorectal cancer samples and our preclinical studies indicate that targeting USP22 in combination with CDK (zeige CDK4 Proteine) inhibitors may offer an approach for treating cancer patients whose tumors exhibit elevated CCND1 (zeige CCND1 Proteine).

  2. these findings suggest that miR (zeige MLXIP Proteine)-30e-5p suppresses non-small cell lung cancer (NSCLC) tumorigenesis by downregulating USP22-mediated Sirt1 (zeige SIRT1 Proteine)/JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine) signaling.

  3. USP22 played an important role in retinoblastoma cell proliferation/aging and apoptosis.

  4. indicate USP22 as a novel deubiquitinase of BMI1 (zeige BMI1 Proteine) in glioma

  5. USP22 mediates CRC (zeige CALR Proteine) cell chemoresistance through the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway and that reducing USP22 in CRC (zeige CALR Proteine) cells diminishes chemoresistance.

  6. Data provided evidence that USP22, an up-stream molecule of AP4 (zeige REPIN1 Proteine), exhibits strong potential to promote colorectal cancer (CRC (zeige CALR Proteine)) metastasis, particularly CRC (zeige CALR Proteine) migration and invasion capacities, both in vitro and in vivo, by inducing EMT (zeige ITK Proteine) via AP4 (zeige REPIN1 Proteine) activating. Moreover, USP22 and AP4 (zeige REPIN1 Proteine) overexpression may stimulate tumor metastasis and adversely affect overall survival in CRC (zeige CALR Proteine) patients.

  7. Cancer stem cells marker USP22 influences drug sensitivity via regulating SIRT1 (zeige SIRT1 Proteine), which will shed new insights into the mechanisms of multidrug resistance in hepatocellular carcinoma .

  8. our study demonstrates that USP22 is indispensable for gastric cancer stem cell self-renewal through stabilization of BMI1 (zeige BMI1 Proteine).

  9. Downregulation of USP22 in ATC (zeige SRPK1 Proteine) cells impeded tumor growth and lung metastasis in vivo.

  10. Studies indicate that aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis.

Mouse (Murine) Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartner

  1. Usp22 is the first deubiquitinase reported to regulate both V(D)J recombination and class switch recombination in vivo by facilitating classical non-homologous end joining.

  2. high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.

  3. that nuclear GSK3beta- and USP22-mediated KDM1A (zeige KDM1A Proteine) stabilization is essential for glioblastoma tumorigenesis

  4. Usp22 deficiency impairs intestinal epithelial lineage specification.

  5. USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2 (zeige SOX2 Proteine)) in embryonic stem cells.

  6. Genetic deletion of the usp22 gene results in Sirt1 (zeige SIRT1 Proteine) instability, elevated p53 (zeige TP53 Proteine) transcriptional activity and early embryonic lethality.

USP22 Protein Überblick

Protein Überblick

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).

Genbezeichner und Symbole assoziert mit USP22

  • ubiquitin specific peptidase 22 (USP22)
  • ubiquitin specific peptidase 22 (Usp22)
  • ubiquitin specific peptidase 22 (usp22)
  • ubiquitin specific peptidase 22 S homeolog (usp22.S)
  • AI427806 Protein
  • usp3l Protein
  • usp22 Protein
  • usp22 b Protein
  • usp22-a Protein
  • usp22-B Protein
  • zgc:136342 Protein

Bezeichner auf Proteinebene für USP22

deubiquitinating enzyme 22 , ubiquitin carboxyl-terminal hydrolase 22 , ubiquitin specific protease 22 , ubiquitin thioesterase 22 , ubiquitin thiolesterase 22 , ubiquitin-specific processing protease 22 , ubiquitin-specific-processing protease 22 , ubiquitin specific peptidase 22 , ubiquitin carboxyl-terminal hydrolase 22-like , Deubiquitinating enzyme 22-B , Ubiquitin thioesterase 22-B , Ubiquitin-specific-processing protease 22-B , deubiquitinating enzyme 22 B , ubiquitin carboxyl-terminal hydrolase 22-B , ubiquitin specific peptidase 22 b , ubiquitin thioesterase 22 B , ubiquitin thiolesterase 22-B , ubiquitin-specific-processing protease 22 B

23326 Homo sapiens
216825 Mus musculus
303201 Rattus norvegicus
609588 Canis lupus familiaris
692275 Danio rerio
712098 Macaca mulatta
100053238 Equus caballus
100340977 Oryctolagus cuniculus
100379835 Xenopus (Silurana) tropicalis
100456449 Pongo abelii
100476428 Ailuropoda melanoleuca
454511 Pan troglodytes
509694 Bos taurus
100729060 Cavia porcellus
779144 Xenopus laevis
Ausgewählte Anbieter für USP22 Proteine (USP22)
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