Ubiquitin Specific Peptidase 22 Proteine (USP22)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Zusätzlich bieten wir Ihnen USP22 Antikörper (83) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP22 23326 Q9UPT9
USP22 216825 Q5DU02
Ratte USP22 USP22 303201  
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Showing 2 out of 2 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details

USP22 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Mouse (Murine)

Weitere Proteine zu Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartnern

Human Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartner

  1. correlation exists between USP22 and HSP90 expressions in gastric cancer and co-expression of USP22 and HSP90 may be more effective in predicting prognosis of gastric cancer

  2. Targeting USP22 represents a potential therapeutic approach to suppress cancer-initiating cells (CIC) in lung adenocarcinoma partially through downregulation of ALDH1A3 expression.

  3. USP22 could interact directly with MKK6 promoter. Down-regulation of USP22 led to the decreased MKK6 mRNA expression

  4. USP22-NLs-CD44 was demonstrated to be able to effectively deliver USP22 siRNA to CD44(+) gastric cancer stem cells, achieving superior therapeutic effects against CD44(+) gastric cancer stem cells than nontargeted nanoliposomes. USP22-NLs-CD44 may provide a novel approach to eradicate gastric cancer stem cells in the near future

  5. After the knockdown of USP22 by siRNA, the abilities of glioma cell proliferation, migration and invasion were decreased, accompanying, the expression of MMP2 was also decreased. We drew a conclusion that USP22 could increase the abilities of proliferation, migration and invasion of glioma cells, and promote the growth and development of glioma

  6. USP22 and CCND1 levels correlate in patient lung and colorectal cancer samples and our preclinical studies indicate that targeting USP22 in combination with CDK inhibitors may offer an approach for treating cancer patients whose tumors exhibit elevated CCND1.

  7. these findings suggest that miR-30e-5p suppresses non-small cell lung cancer (NSCLC) tumorigenesis by downregulating USP22-mediated Sirt1/JAK/STAT3 signaling.

  8. USP22 played an important role in retinoblastoma cell proliferation/aging and apoptosis.

  9. indicate USP22 as a novel deubiquitinase of BMI1 in glioma

  10. USP22 mediates CRC cell chemoresistance through the Wnt/beta-catenin pathway and that reducing USP22 in CRC cells diminishes chemoresistance.

  11. Data provided evidence that USP22, an up-stream molecule of AP4, exhibits strong potential to promote colorectal cancer (CRC) metastasis, particularly CRC migration and invasion capacities, both in vitro and in vivo, by inducing EMT via AP4 activating. Moreover, USP22 and AP4 overexpression may stimulate tumor metastasis and adversely affect overall survival in CRC patients.

  12. Cancer stem cells marker USP22 influences drug sensitivity via regulating SIRT1, which will shed new insights into the mechanisms of multidrug resistance in hepatocellular carcinoma .

  13. our study demonstrates that USP22 is indispensable for gastric cancer stem cell self-renewal through stabilization of BMI1.

  14. Downregulation of USP22 in ATC cells impeded tumor growth and lung metastasis in vivo.

  15. Studies indicate that aberrant expression of the Ubiquitin-Specific Peptidase 22 (USP22) has been associated with poor cancer prognosis.

  16. we demonstrated that USP22 was highly expressed in OS tissues and cells lines. Downregulation of USP22 inhibited OS cell proliferation, invasion, and EMT in vitro. In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo.

  17. In breast cancer cell lines USP22 increases c-Myc stability through c-Myc deubiquitination, which is closely correlated with breast cancer progression.

  18. that nuclear GSK3beta- and USP22-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis

  19. findings suggest that USP22 may be involved in hepatocellular carcinoma progression in cooperation with survivin.

  20. These findings provide evidence that high USP22 expression might be important in tumor progression and serves as an independent molecular marker for poor hepatocellular carcinoma prognosis

Mouse (Murine) Ubiquitin Specific Peptidase 22 (USP22) Interaktionspartner

  1. a CD26-related linkage with USP22 in Malignant pleural mesothelioma cell inhibition induced by anti-CD26 monoclonal antibody HuCD26mAb

  2. Usp22 is the first deubiquitinase reported to regulate both V(D)J recombination and class switch recombination in vivo by facilitating classical non-homologous end joining.

  3. high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.

  4. that nuclear GSK3beta- and USP22-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis

  5. Usp22 deficiency impairs intestinal epithelial lineage specification.

  6. USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2) in embryonic stem cells.

  7. Genetic deletion of the usp22 gene results in Sirt1 instability, elevated p53 transcriptional activity and early embryonic lethality.

USP22 Protein Überblick

Protein Überblick

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).

Genbezeichner und Symbole assoziert mit USP22

  • ubiquitin specific peptidase 22 (USP22)
  • ubiquitin specific peptidase 22 (Usp22)
  • ubiquitin specific peptidase 22 (usp22)
  • ubiquitin specific peptidase 22 S homeolog (usp22.S)
  • AI427806 Protein
  • usp3l Protein
  • usp22 Protein
  • usp22 b Protein
  • usp22-a Protein
  • usp22-B Protein
  • zgc:136342 Protein

Bezeichner auf Proteinebene für USP22

deubiquitinating enzyme 22 , ubiquitin carboxyl-terminal hydrolase 22 , ubiquitin specific protease 22 , ubiquitin thioesterase 22 , ubiquitin thiolesterase 22 , ubiquitin-specific processing protease 22 , ubiquitin-specific-processing protease 22 , ubiquitin specific peptidase 22 , ubiquitin carboxyl-terminal hydrolase 22-like , Deubiquitinating enzyme 22-B , Ubiquitin thioesterase 22-B , Ubiquitin-specific-processing protease 22-B , deubiquitinating enzyme 22 B , ubiquitin carboxyl-terminal hydrolase 22-B , ubiquitin specific peptidase 22 b , ubiquitin thioesterase 22 B , ubiquitin thiolesterase 22-B , ubiquitin-specific-processing protease 22 B

GENE ID SPEZIES
23326 Homo sapiens
216825 Mus musculus
303201 Rattus norvegicus
609588 Canis lupus familiaris
692275 Danio rerio
712098 Macaca mulatta
100053238 Equus caballus
100340977 Oryctolagus cuniculus
100379835 Xenopus (Silurana) tropicalis
100456449 Pongo abelii
100476428 Ailuropoda melanoleuca
454511 Pan troglodytes
509694 Bos taurus
100729060 Cavia porcellus
779144 Xenopus laevis
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