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USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. Zusätzlich bieten wir Ihnen USP21 Antikörper (101) und und viele weitere Produktgruppen zu diesem Protein an.
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Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.
Data show that ubiquitin variants (Ubvs) that bind to USP2 (zeige USP2 Proteine) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.
USP21 binds to the promoter region of IL-8 (zeige IL8 Proteine) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (zeige MOK Proteine)
USP21 interacts with, deubiquitinates and stabilizes BRCA2 (zeige BRCA2 Proteine) to promote efficient RAD51 (zeige RAD51 Proteine) loading at DNA double-strand breaks.
a critical role of p38 (zeige CRK Proteine)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (zeige CRK Proteine)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
USP21 recruits and stabilises Gli1 (zeige GLI1 Proteine) at the centrosome.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Data show that SUMOylated BANP (zeige BANP Proteine), E5R, and Nac1 (zeige NACC1 Proteine) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (zeige NKX2-1 Proteine)-interacting protein 5 (zeige CAPS Proteine) (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase
The protein stability of IL-33 (zeige IL33 Proteine) is maintained by USP21 through deubiquitination
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (zeige GATA3 Proteine)
USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse embryonic stem cells to maintain stemness.
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Overexpression of USP21 inhibited RNA virus-induced RIG-I (zeige DDX58 Proteine) polyubiquitination and RIG-I (zeige DDX58 Proteine)-mediated interferon (zeige IFNA Proteine) signaling, while USP21 deletion resulted in elevated RIG-I (zeige DDX58 Proteine) polyubiquitination, IRF3 (zeige IRF3 Proteine) phosphorylation, IFN production, and antiviral responses.
USP21 plays an important role in the down-regulation of TNFalpha (zeige TNF Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) activation through deubiquitinating RIP1 (zeige RALBP1 Proteine).
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
ubiquitin specific peptidase 21
, Ubiquitin specific peptidase 21
, NEDD8-specific protease
, deubiquitinating enzyme 21
, ubiquitin carboxyl-terminal hydrolase 21
, ubiquitin specific protease 21
, ubiquitin thioesterase 21
, ubiquitin thiolesterase 21
, ubiquitin-specific processing protease 21
, ubiquitin-specific protease 16
, ubiquitin-specific-processing protease 21
, ubiquitin specific protease 23
, ubiquitin-specific protease 21