Ubiquitin Specific Peptidase 2 Proteine (USP2)

Human Ubiquitin Specific Peptidase 2 (USP2) Interaktionspartner

1. Data suggest that ubiquitin (Ub) and neural precursor cell expressed developmentally down-regulated 8 (NEDD8) residues 4, 12, 14, and 72 serve as the molecular determinants for specific recognition by ubiquitin specific protease 2 protein (USP2).

2. In general, we collect and summarize the factors involved in the alternative splicing of USP2 in this review to further understand the mechanism behind the USP2's alternative splicing

3. Authors show here USP2 is expressed in quiescent and activated T-cells and its expression is 50% lower in CTCL cell lines (MyLa2000, SeAx and Hut-78) than in normal T-cells.

4. Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.

5. The results show a connection between miR-125b and USP2 gene the etiology of psoriasis. They proceeded to show that modulation of nuclear factor kappa B-mediated inflammation is the likely mechanism through which this miRNA gene pair function

6. the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1, and inhibits K48-linked ubiquitination and degradation of pY701-STAT1

7. ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth.

8. Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR by IDOL.

9. Data suggest up-regulation of ASAH1 (acid ceramidase) activity by androgen in androgen-sensitive prostate cancer cells (but not other cancer cells) is mainly due to prolonged stability of ASAH1 by androgen-stimulated induction of USP2 expression.

10. Modulation of USP-2 expression plays a crucial role in cell cycle regulation by leptin and adiponectin.

11. Our findings suggest that USP2a mRNA may be considered as a diagnostic marker candidate for bladder cancer, in particular, to stratify MIBC patients with a more invasive phenotype.

12. The present study showed that USP2 expression is associated with TNBC cell line's invasiveness and poor survival of breast cancer patients and may serve as a prognostic biomarker and therapeutic target for TNBC

13. findings demonstrated that USP2b deubiquitinates K63-linked polyubiquitin chains from TBK1 to terminate TBK1 activation and negatively regulate IFN-beta signaling and antiviral immune response.

14. Loss of USP2a expression is associated with glioblastoma.

15. USP2a increases intracellular glutathione content, thus interfering with the oxidative cascade triggered by chemotherapeutic agents.

16. USP2 and its substrate, fatty acid synthase (FASN), are over-expressed in glioma tissue.

17. we have demonstrated that USP2a plays a negative regulatory role in IL-1beta- and SeV-induced NF-kappaB activation.

18. USP2a plays an important role in TCR signaling by deSUMOylating TRAF6 and mediating TRAF6-MALT1 interaction

19. USP2a antagonizes EGFR endocytosis and thus amplifies signaling activity from the receptor.

20. TRAF2 inhibits USP2a effect on K48- but not on K63-linked ubiquitin chains.

Mouse (Murine) Ubiquitin Specific Peptidase 2 (USP2) Interaktionspartner

1. 3,3'-Diindolylmethane directly inhibits USP2 deubiquitinase activity in 3T3-L1 pre-adipocytes.

2. Usp2 is required for the PTH1-34-induced proliferation of osteoblasts

3. Usp2 is a clock output effector related to bodily Ca2+ homeostasis, a feature that is conserved across evolution.

4. A novel function of USP2 in the molecular clock in which it regulates PER1 function.

5. A role for USP2-45 as a central regulator of MR, able to remove the receptor monoubiquitylation and induced its destabilization.

6. Data suggest that USP2 does not play a primary role in the control of sodium balance or blood pressure.

7. a functional liver clock is required for the proper nutritional and circadian regulation of USP2-45 expression; at the molecular level, transcriptional coactivators PGC-1alpha and PGC-1beta and repressor E4BP4 exert opposing effects on USP2-45 promoter activity

8. USP2a potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation.

9. These studies delineate a novel pathway that links hormonal and circadian signals to gluconeogenesis and glucose homeostasis.

10. Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes

11. severe defect in the ability of Usp2 -/- spermatozoa to fertilize eggs

12. TNFalpha-induced USP2 down-regulation is an effective cytoprotective mechanism in hepatocytes.

Zebrafish Ubiquitin Specific Peptidase 2 (USP2) Interaktionspartner

1. High expression of USP2a in brain tissue from primary glioma patients was correlated with poor survival.