anti-Ubiquitin Specific Peptidase 1 (USP1) Antikörper

USP1 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP1 Proteine (7) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
USP1 7398 O94782
USP1 230484 Q8BJQ2
USP1 313387 Q569C3
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Top anti-USP1 Antikörper auf antikoerper-online.de

Showing 10 out of 108 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-USP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human brain WB Suggested Anti-USP1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Human brain 100 μL 2 bis 3 Tage
$319.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of USP1 expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and human liver tissue labeled with Anti-USP-1 Polyclonal Antibody, Unconjugated (ABIN675578) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and human glioma tissue labeled with Anti-USP-1 Polyclonal Antibody, Unconjugated (ABIN675578) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 bis 7 Tage
$317.90
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μg 2 bis 3 Tage
$335.00
Details
Hund Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$581.17
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-USP1 Pab in HepG2 cell line lysate (35ug/lane). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB ABIN6273409 at 1/100 staining Human brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of USP1 expression in Human fetal brain lysate,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert WB 100 μL 11 bis 13 Tage
$366.77
Details

Am meisten referenzierte anti-USP1 Antikörper

  1. Human Polyclonal USP1 Primary Antibody für IP - ABIN257791 : Lee, Yang, Cohn, Sikdar, DAndrea, Myung: Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal USP1 Primary Antibody für IHC, IHC (p) - ABIN257792 : Murai, Yang, Dejsuphong, Hirota, Takeda, DAndrea: The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. in Molecular and cellular biology 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal USP1 Primary Antibody für IHC (p), ELISA - ABIN544869 : Fujiwara, Saito, Suzuki, Shinomiya, Suzuki, Takahashi, Tanigami, Ichiyama, Chung, Nakamura, Tanaka: Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. in Genomics 1999 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal USP1 Primary Antibody für IHC, IHC (p) - ABIN4364533 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

Weitere Antikörper gegen USP1 Interaktionspartner

Human Ubiquitin Specific Peptidase 1 (USP1) Interaktionspartner

  1. USP1 exhibits DNA-mediated activation at the replication fork, protects the fork, and promotes survival in BRCA1-deficient tumor cells.

  2. In this report, the authors provide evidence that the previously described interaction between the viral E1 helicase and the cellular UAF1-USP1 deubiquitinating enzyme complex is required for the completion of the bidirectional theta replication of the human papilloma virus type 11 genome and the subsequent initiation of the unidirectional replication.

  3. Three crystal structures have been reported of a CRL2 substrate receptor, KLHDC2, in complex with the diglycine-ending C-end degrons of an early terminated selenoprotein, SelK, and the N-terminal proteolytic fragment of USP1.

  4. USP1-mediated deubiquitination and stabilization of KPNA2 are revealed as the downstream events crucial for USP1-pro-metastatic function.

  5. USP1 and capital ER, Cyrilliccapital EN, Cyrillic domain of Bcr-Abl oncoprotein colocalize in a model chronic myeloid leukemia cell system.

  6. Our preclinical studies provide the framework for clinical evaluation of USP1 inhibitors, alone or in combination, as a potential novel multiple myeloma therapy.

  7. There is evidence that USP1/WDR48 complex promotes cancer stem cell conservation and regulation of DNA damage repair. [REVIEW]

  8. These results outline a novel mechanism for the control of TBK1 activity and suggest USP1-UAF1 complex as a potential target for the prevention of viral diseases.

  9. USP1 is a key senescence regulator controlling genomic integrity.

  10. High USP1 expression is associated with glioma.

  11. USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.

  12. The results suggest that silencing USP1 inhibits cell proliferation and invasion in U2OS cells. Therefore, USP1 may provide a novel therapeutic target for the treatment of osteosarcoma.

  13. Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance.

  14. Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM.

  15. analysis of the function and regulation of the USP1-UAF1 complex

  16. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review)

  17. No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA in BAF180 expressing cells

  18. USP1 phosphorylation at S313 is not critical for PCNA deubiquitination, neither for binding to UAF1 in a cellular environment.

  19. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1, USP12 and USP46.

  20. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1

Mouse (Murine) Ubiquitin Specific Peptidase 1 (USP1) Interaktionspartner

  1. our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1, and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality.

  2. Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2) and Pcna (proliferating cell nuclear antigen).

  3. Homozygous Uaf1(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded.

  4. Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway.

  5. Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.

  6. mouse Usp1 functions downstream in the Fanconi anemia pathway, and its deubiquitination is required for Fancd2 nuclear foci assembly

USP1 Antigen-Profil

Protein Überblick

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Genbezeichner und Symbole assoziert mit USP1

  • ubiquitin specific peptidase 1 (USP1) Antikörper
  • ubiquitin specific peptidase 1 S homeolog (usp1.S) Antikörper
  • ubiquitin specific peptidase 1 (Usp1) Antikörper
  • UBP Antikörper
  • usp1-a Antikörper

Bezeichner auf Proteinebene für USP1

ubiquitin carboxyl-terminal hydrolase 1 , ubiquitin specific protease 1 , ubiquitin specific peptidase 1 , ubiquitin carboxyl-terminal hydrolase 1-like , deubiquitinating enzyme 1 , hUBP , ubiquitin carboxyl terminal hydrolase 1 , ubiquitin specific processing protease 1 , ubiquitin thioesterase 1 , ubiquitin thiolesterase 1 , ubiquitin-specific-processing protease 1 , ubiquitin specific peptdiase 1

GENE ID SPEZIES
100070397 Equus caballus
447465 Xenopus laevis
456901 Pan troglodytes
695157 Macaca mulatta
100443075 Pongo abelii
7398 Homo sapiens
230484 Mus musculus
313387 Rattus norvegicus
424685 Gallus gallus
479549 Canis lupus familiaris
100523071 Sus scrofa
516328 Bos taurus
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