Ubiquitin Carboxyl-terminal Hydrolase L5 Proteine (UCHL5)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Zusätzlich bieten wir Ihnen UCHL5 Antikörper (113) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
UCHL5 56207 Q9WUP7
UCHL5 51377 Q9Y5K5
Ratte UCHL5 UCHL5 360853  
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Top UCHL5 Proteine auf antikoerper-online.de

Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Rind (Kuh) His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage

UCHL5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, , ,

Weitere Proteine zu Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) Interaktionspartnern

Human Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) Interaktionspartner

  1. Rpn13-Rpn2 complex structural analysis shows that RA190 targets hRpn13 and Uch37 through parallel mechanisms and at proteasomes, RA190-inactivated Uch37 cannot disassemble hRpn13-bound ubiquitin chains

  2. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway.

  3. Our studies provide a molecular mechanism by which UCHL5 mitigates TGFbeta-1 signaling by stabilizing Smad2/Smad3. These data indicate that UCHL5 may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target.

  4. Positive cytoplasmic UCHL5 tumor immunoexpression is linked to increased survival of patients with small (<5 cm) tumors (p = 0.001), disease stages I-II (p = 0.025), and age 66 years or older (p = 0.037). UCHL5 is thus a potential marker in gastric cancer with new prognostic relevance.

  5. our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  6. UCHL5 is a promising novel prognostic marker in lymph-node-positive rectal cancer. Our results also advance the currently limited knowledge of biomarkers in colorectal cancer treatment.

  7. UCHL5 expression could function as a prognostic marker in pancreatic ductal adenocarcinoma, particularly at disease stages IIB to III. As UCHL5 is one of the few markers predicting increased survival, our results may be of clinical relevance.

  8. this work implicates hRpn13 and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13-targeting molecule RA190.

  9. These results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63-linked ubiquitination by UCH37.

  10. Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.

  11. Data show that DEUBAD domain in RPN13 (ADRM1) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB) inhibits UCH-L5.

  12. Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.

  13. High expression of UCH37 is significantly associated with epithelial ovarian cancer.

  14. b-AP15 is an inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

  15. UCH37 over-expression is associated with hepatocellular carcinoma recurrence.

  16. UCH37 is associated with outcome and recurrence of ESCC and can be a novel predictor for poor prognosis of esophageal squamous cell carcinoma patients after curative resection.

  17. a functional proteomic analysis was performed to screen UCH37-interacting proteins in hepatocellular carcinoma (HCC), and glucose-regulated protein 78 was identified as one interacting with UCH37

  18. our structures reveal conformationally dynamic parts of the enzyme that may play a role in the structural transition to the more active form.

  19. Silencing of UCH37 in A549 cells induced apoptosis.

  20. UCH37 interacts with Smads and regulates TGF-beta signalling.

Cow (Bovine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) Interaktionspartner

  1. Neither Uch37 alone nor the Uch37-Adrm1 or Uch37-Adrm1-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin chains.

UCHL5 Protein Überblick

Protein Überblick

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Genbezeichner und Symbole assoziert mit UCHL5

  • ubiquitin carboxyl-terminal hydrolase L5 (uchl5)
  • ubiquitin C-terminal hydrolase L5 (UCHL5)
  • ubiquitin C-terminal hydrolase L5 L homeolog (uchl5.L)
  • ubiquitin C-terminal hydrolase L5 (uchl5)
  • ubiquitin carboxyl-terminal esterase L5 (Uchl5)
  • ubiquitin C-terminal hydrolase L5 (Uchl5)
  • 5830413B11Rik Protein
  • CGI-70 Protein
  • DKFZp459M0513 Protein
  • INO80R Protein
  • UCH-L5 Protein
  • UCH37 Protein
  • wu:fj17f09 Protein
  • zgc:85615 Protein

Bezeichner auf Proteinebene für UCHL5

ubiquitin carboxyl-terminal hydrolase isozyme L5 , ubiquitin carboxyl-terminal hydrolase L5 , UCH-L5 , ubiquitin C-terminal hydrolase 37 , ubiquitin C-terminal hydrolase UCH37 , ubiquitin thioesterase L5 , INO80 complex subunit R , ubiquitin carboxyl-terminal esterase L5

406357 Danio rerio
424359 Gallus gallus
457596 Pan troglodytes
478958 Canis lupus familiaris
733154 Xenopus laevis
100124308 Xenopus (Silurana) tropicalis
100174635 Pongo abelii
100195039 Salmo salar
100349016 Oryctolagus cuniculus
56207 Mus musculus
51377 Homo sapiens
360853 Rattus norvegicus
282110 Bos taurus
100144472 Sus scrofa
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