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Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. Zusätzlich bieten wir Ihnen UBXN6 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin.
Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis
Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1.
UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.
Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells.
UBXD1 is a novel co-factor of the human p97 ATPase.
An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified.
these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP.
Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).
UBX domain containing 1
, UBX domain-containing protein 6
, UBX domain protein 6
, UBX domain-containing 1
, UBX domain-containing 2
, UBX domain-containing protein 1