UBX Domain Protein 6 Proteine (UBXN6)

Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. Zusätzlich bieten wir Ihnen UBXN6 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte UBXN6 UBXN6 363332  
UBXN6 80700 Q9BZV1
Maus UBXN6 UBXN6 66530 Q99PL6
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Top UBXN6 Proteine auf antikoerper-online.de

Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Hefe Yeast His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,094.67
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,234.00
Details

UBXN6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu UBX Domain Protein 6 (UBXN6) Interaktionspartnern

Human UBX Domain Protein 6 (UBXN6) Interaktionspartner

  1. Upon damage, p97 (zeige EIF4G2 Proteine) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA (zeige PLAA Proteine), and the deubiquitinating enzyme YOD1 (zeige YOD1 Proteine), which we term ELDR components for Endo-Lysosomal Damage Response.

  2. UBXD1-N intercalates into the p97 (zeige EIF4G2 Proteine)-ND1 (zeige MT-ND1 Proteine) interface, thereby modulating interdomain communication of p97 (zeige EIF4G2 Proteine) domains and its activity with relevance for disease pathogenesis

  3. Data indicate that endosomal trafficking of CAV1 (zeige CAV1 Proteine) depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP (zeige vcp Proteine)-UBXD1.

  4. UBXD1 modulates the trafficking of ERGIC-53 (zeige LMAN1 Proteine)-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53 (zeige LMAN1 Proteine).

  5. Data show that expression of VCP (zeige vcp Proteine) mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 (zeige CAV1 Proteine) transport at the limiting membrane of enlarged endosomes in cultured cells.

  6. UBXD1 is a novel co-factor of the human p97 ATPase (zeige vcp Proteine).

  7. An additional p97 (zeige EIF4G2 Proteine) binding site in UBXD1 that competed with the p47 (zeige ING1 Proteine) cofactor for binding to the N domain of p97 (zeige EIF4G2 Proteine) was identified.

  8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP.

UBXN6 Protein Überblick

Protein Überblick

Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).

Genbezeichner und Symbole assoziert mit UBX Domain Protein 6 Proteine (UBXN6)

  • UBX domain protein 6 (Ubxn6)
  • UBX domain protein 6 (UBXN6)
  • 1200008L11Rik Protein
  • 2210415J11Rik Protein
  • AU040909 Protein
  • UBXD1 Protein
  • Ubxdc2 Protein

Bezeichner auf Proteinebene für UBX Domain Protein 6 Proteine (UBXN6)

UBX domain containing 1 , UBX domain-containing protein 6 , UBX domain protein 6 , UBX domain-containing 1 , UBX domain-containing 2 , UBX domain-containing protein 1

GENE ID SPEZIES
363332 Rattus norvegicus
715070 Macaca mulatta
100018491 Monodelphis domestica
100589901 Nomascus leucogenys
80700 Homo sapiens
66530 Mus musculus
507936 Bos taurus
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