Tyrosine-Protein Phosphatase Non-Receptor Type 22 Proteine (PTPN22)

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Zusätzlich bieten wir Ihnen PTPN22 Antikörper (79) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
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Showing 5 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human PTPN22 Protein. 100 μg 11 bis 18 Tage
Escherichia coli (E. coli) Ratte Unkonjugiert SDS-PAGE analysis of Rat PTPN22 Protein. 100 μg 11 bis 18 Tage

PTPN22 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Am meisten referenzierte PTPN22 Proteine

  1. Human PTPN22 Protein expressed in Wheat germ - ABIN1316837 : Bayley, Yang, Buckley, Young: Measuring the specific activity of the protein tyrosine phosphatase Lyp. in Journal of immunological methods 2013 (PubMed)

Weitere Proteine zu Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaktionspartnern

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaktionspartner

  1. The data point to two related but distinct mechanisms by which PTPN22 regulates LFA-1 dependent signals to enhance Th1 development, highlighting how perturbations to PTPN22 function over time to regulate the balance of the immune response.

  2. The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases [Review].

  3. these findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease

  4. PTPN22 role in CD8-positive t cells activation.

  5. This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.

  6. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 repressor, cAMP-responsive element modulator is reduced.

  7. we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis

  8. Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.

  9. PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.

  10. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1).

  11. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.

  12. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

  13. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  14. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta.

  15. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  16. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  17. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

  18. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  19. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.

  20. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaktionspartner

  1. Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.

  2. PTPN22 gene polymorphism in rs1310182 could play a crucial role in susceptibility to ulcerative colitis

  3. Our data showed that the PTPN22 R620W polymorphism is a risk factor for Takayasu's arteritis (TA) (CC vs. CT: OR 4.3, p = 0.002, and C vs. T: OR 4.1, p = 0.003); however, the PTPN22 R263Q and - 1123G/C polymorphisms are not associated with this autoimmune disease. In addition, the PTPN22 CGT haplotype, which carries the minor allele of the PTPN22 C1858T variant, was also associated with TA susceptibility.

  4. results showed that the PTPN22 +788 G>A polymorphism is not associated with RA susceptibility in western Mexican population, whereas the presence of G/A genotype is associated with increased PTPN22 mRNA expression in RA patients

  5. PTPN22 rs2476601 polymorphism frequency was higher in rheumatoid arthritis and undifferentiated arthritis vs the general population; however, this was significantly different only for rheumatoid arthritis vs control group.

  6. The findings of the current investigation suggested a significant association between the rs2476601 polymorphism of PTPN22 gene and Alopecia Areata. The C-allele and CC-genotype carriers at this locus have a lower risk of Alopecia Areata.

  7. In a genome-wide association study, we identified rs2476601 in PTPN22 as a non-HLA variant that associates with risk of liver injury caused by multiple drugs and validated our finding in a separate cohort.

  8. Studied association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) single nucleotide polymorphisms (SNPs) with the increased activation and proliferation of T helper cells, specifically CD154 antigen expression and CD+ T cells, in subjects with rheumatoid arthritis.

  9. PTPN22 is down-regulated in patients with rheumatoid arthritis carrying the risk alleles of PTPN22 rs2488457 and rs2476601.

  10. The T allele is associated only in cases with Juvenile idiopathic arthritis (JIA) and it may be considered as risk allele for certain JIA subtypes in Egyptian patients.

  11. PTPN22 is implicated in signalling pathways involved in the autoimmune and autoinflammatory processes underlying rheumatoid arthritis; a nonsynonymous polymorphism of PTPN22 (R620W), located in the first proline-rich motif of LYP, was described as major susceptibility factor

  12. A rare variant of PTPN22 was linked to Hashimoto's thyroiditis in a Chinese pedigree.

  13. Lack of association between PTPN22 R620W variant and IBD susceptibility in Moroccan patients.

  14. RA samples with PTPN2:rs478582 and/or PTPN22:rs2476601 were more positive for MAP than samples without polymorphisms. Combined occurrence of PTPN2:rs478582 and PTPN22:rs2476601 in association with the presence of MAP has significantly increased T-cell response and elevated IFN-gamma expression in RA samples.

  15. The authors propose a novel mechanism of action of PTPN22 risk allele through the generation of cytotoxic CD4(+) T cells and identify EOMES(+) CD4(+) T cells as a relevant T-cell subset in RA pathogenesis.

  16. our data indicate a novel role for PTPN2 and PTPN22 in controlling intestinal microbiota composition and further elucidate the complex interplay between genetic risk factors, intestinal microbiota and disease course in IBD patients.

  17. Significant associations were found for SH2B3 T allele and PTPN22 A allele and autoimmune hepatitis

  18. A significant association was detected between the variant genotype of the PTPN22 gene (C1858T, rs2476601) and T1DM in Kuwaiti Arabs. HLA-DQ2 and DQ8 alleles showed a strong association with T1DM. Of T1DM patients having the variant TT-genotype of the PTPN22 gene, 93% had at least one DQ2 allele and 60% had either a DQ2 or a DQ8 allele. TT homozygotes had either DR3-DRB5 or DRB3-DRB4 genotypes.

  19. PTPN22 and CTLA-4 polymorphisms are associated with Autoimmune polyglandular syndromes and differentiate between polyglandular and monoglandular autoimmunity.

  20. gene expression levels of PTPN22 were higher in the alopecia areata patients in Iranian population; association between the PTPN22 genetic variation was not confirmed by this study

PTPN22 Protein Überblick

Protein Überblick

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Genbezeichner und Symbole assoziert mit PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22)
  • protein tyrosine phosphatase, non-receptor type 22 (PTPN22)
  • protein tyrosine phosphatase, non-receptor type 22 (Ptpn22)
  • 70zpep Protein
  • LYP Protein
  • LYP1 Protein
  • LYP2 Protein
  • PEP Protein
  • PTPN8 Protein

Bezeichner auf Proteinebene für PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
Ausgewählte Anbieter für PTPN22 Proteine (PTPN22)
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