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TYRP1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Zusätzlich bieten wir Ihnen Tyrosinase-Related Protein 1 Antikörper (297) und Tyrosinase-Related Protein 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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The rs387907171 SNP in TYRP1 exhibits strong allele frequency differences among islands in Northern Island Melanesia. Its absence from Bougainville, as well as the weak association with decreased hair color, indicates that additional alleles contribute to the blondism phenotype.
TYRP1-dependent miR-16 (zeige GDE1 Proteine) sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16 (zeige GDE1 Proteine)-binding sites on TYRP1 mRNA.
The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 (zeige GDE1 Proteine).
DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.
Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.
Mutation in TYRP1 is associated with oculocutaneous albinism.
Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR (zeige MLXIP Proteine)-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR (zeige MLXIP Proteine)-155 activity
These data suggest that UVB-stimulated Ucn1 contributes to TRP1 production via the transcription of both Nurr-1 and Nur77. Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
These data indicate that galectin-3 (zeige LGALS3 Proteine) is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.
p53 (zeige TP53 Proteine) regulation by TRP2 (zeige DCT Proteine) is not pervasive in melanoma.
a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype
The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE (zeige RPE Proteine) cells and the NCDM in zebrafish.
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.
we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR (zeige TYR Proteine)), as well as genes with unknown functions.
A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.
Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.
the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 (zeige TRPC1 Proteine) protein expression by post-transcriptional control in B16F10 cells
Studied upregulation by Kaliziri extract of tyrosinase (zeige TYR Proteine), TRP-1 (zeige TRPC1 Proteine), TRP-2 (zeige DCT Proteine) and MITF (zeige MITF Proteine) expression in murine B16 melanoma cells.
The SNARE (zeige VTI1B Proteine) machinery composed of VAMP7 (zeige VAMP7 Proteine) on Tyrp1-containing vesicles and syntaxin-3 (zeige STX3 Proteine) and SNAP23 (zeige SNAP23 Proteine) on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Addition of a TRP-1 (zeige TRPC1 Proteine)-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.
analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage
GILT (zeige IFI30 Proteine)-deficient mice have an increase in TRP1 (zeige TRPC1 Proteine)-specific regulatory T (Treg) cells compared with TRP1 (zeige TRPC1 Proteine)-deficient mice, and depletion of Treg cells partially restores the ability of GILT (zeige IFI30 Proteine)-deficient TRP1 (zeige TRPC1 Proteine)-specific CD4 (zeige CD4 Proteine)(+) T cells to induce vitiligo (zeige MITF Proteine).
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.
DNA vaccination with a melanoma-shared antigen Trp1 (zeige TRPC1 Proteine), combined with systemic TGF-beta (zeige TGFB1 Proteine) blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.
both the Rab32 (zeige RAB32 Proteine)/38 binding activity and VAMP7 (zeige VAMP7 Proteine) binding activity of Varp (zeige ANKRD27 Proteine) are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 (zeige RAB21 Proteine) by the VPS9 domain is not necessary for Tyrp1 trafficking
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
5,6-dihydroxyindole-2-carboxylic acid oxidase
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75
, tyrosinase-related protein 1
, tyrosinase-related protein-1
, tyrosine phosphatase 1, same as B (Brown)
, 5,6-dihydroxyindole-2-carboxylic acid oxidase-like
, brown locus protein
, iris stromal atrophy