anti-Tyrosinase  (TYR) Antikörper

The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Zusätzlich bieten wir Ihnen Tyrosinase  Kits (65) und Tyrosinase  Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TYR 7299 P14679
TYR 22173 P11344
TYR 308800  
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Top anti-Tyrosinase  Antikörper auf antikoerper-online.de

Showing 10 out of 282 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, FACS, IF, IHC (p), WB Fow Cytometric analysis of A375 cells using Tyrosinase Antibody (C-term) Cat.-No AP17815PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of Tyrosinase Antibody (C-term) Cat.-No AP17815PU-N with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TYR Antibody Titration:  1.25ug/ml  Positive Control:  Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$249.00
Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of Tyrosinase staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Tyrosinase staining in human liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Western blot (WB) analysis of TYR (R501) polyclonal antibody at 1:500 dilution Lane1:podocyte whole cell lysate(40ug) Lane2:SCC-7 whole cell lysate(40ug) Lane3:A375 whole cell lysate(40ug) 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$325.00
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB ABIN6269033 staining COS7 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. ABIN6269033 staining LOVO cells by ICC/IF. Cells were fixed with PFA and permeabilized in 0.1% saponin prior to blocking in 10% serum for 45 minutes at 37°C. The primary antibody was diluted 1/400 and incubated with the sample for 1 hour at 37°C. A Alexa Fluor® 594 conjugated goat polyclonal to rabbit IgG (H+L), diluted 1/600 was used as secondary antibody. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COS7 cells, treated with UV 30', using Tyrosinase Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Maus Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using TYR antibody. 100 μL Anmelden zum Anzeigen 13 bis 14 Tage
$393.25
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: Jurkat B: Raji 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Cat Maus Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB Human Skin (formalin-fixed, paraffin-embedded) stained with TYR antibody ABIN573956 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-Tyrosinase antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 125 μL Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Western blot analysis of extracts of mouse face and mouse liver  tissues, using TYR antibody. 100 μL Anmelden zum Anzeigen 11 bis 13 Tage
$366.77
Details

Am meisten referenzierte anti-Tyrosinase  Antikörper

  1. Human Polyclonal TYR Primary Antibody für IF, IHC - ABIN6712034 : Ye, Chou, Wang, Chu, Yu: Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2011 (PubMed)
    Show all 3 Pubmed References

  2. Fungus Polyclonal TYR Primary Antibody für ELISA, WB - ABIN2477015 : Lezzi, Bleve, Spagnolo, Perrotta, Grieco: Production of recombinant Agaricus bisporus tyrosinase in Saccharomyces cerevisiae cells. in Journal of industrial microbiology & biotechnology 2012 (PubMed)

  3. Human Polyclonal TYR Primary Antibody für IHC, WB - ABIN6672737 : Zhang, Wang, Yu, Jiang, Yue, Liu: Identification of a gene encoding microphthalmia-associated transcription factor and its association with shell color in the clam Meretrix petechialis. in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2018 (PubMed)

Weitere Antikörper gegen Tyrosinase  Interaktionspartner

Zebrafish Tyrosinase  (TYR) Interaktionspartner

  1. Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.

Atlantic Salmon (Salmo salar) Tyrosinase  (TYR) Interaktionspartner

  1. Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK-1) is influenced by temperature, but not by virus infection or bacterin stimulation.

Human Tyrosinase  (TYR) Interaktionspartner

  1. These results suggest that TYR c.307T>C mutation might be responsible for Oculocutaneous albinism (OCA), and our study further expands the mutation spectrum of OCA1 in the Chinese population

  2. Of six probands with only a single heterozygous mutation in TYR, all were found to have the two common variants S192Y and R402Q. Our results suggest that a combination of R402Q and S192Y with a deleterious mutation in a 'tri-allelic genotype' can account for missing heritability in some hypomorphic OCA1 albinism phenotypes.

  3. Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein.

  4. The effect of histidine mutations on the structural stability of human tyrosinase leading to albinism has been reported.

  5. Compound heterozygous mutations (c.832C>T and c.929_930insC) in the TYR gene may be responsible for partial clinical manifestations of oculocutaneous albinism

  6. Mutations in tyrosinase gene is associated with Oculocutaneous albinism type 1.

  7. tyrosinase as a potential GPR143 binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.

  8. Aberrant tyrosinase expression in an atypical fibroxanthoma

  9. Findings suggested that miR-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 expression.

  10. Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage

  11. LEF-1 and MITF regulate tyrosinase gene transcription in vitro via binding to its promoter.

  12. Data show that mutant microphthalmia-associated transcription factor (MITF) with loss of localization signals (NLS) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.

  13. The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app. 60%) albinism patients.

  14. The two mutations (c.1114delG in the TYR gene and c.1426A>G in the OCA2 gene) may be responsible for partial clinical manifestations of Oculocutaneous albinism.

  15. Molecular analysis identified two compound heterozygous TYR mutations known to cause OCAIA and cosegregate with oculocutaneous albinism. In addition, we identified a novel heterozygous PAX6 mutation confirming the atypical aniridia phenotype.

  16. Overall, our data strongly suggest that IRF4, MC1R and TYR genes likely have pleiotropic effects, a combination of pigmentation and oncogenic functions, resulting in an increased risk of actinic keratosis.

  17. Data indicate that tyrosinase is used as a reporter gene owing to its strong optical absorption and enzymatic amplification mechanism and melamin production.

  18. Identification of four novel TYR mutations in a Chinese Han population with Oculocutaneous albinism 1.

  19. 11/11 individuals with homozygous or compound heterozygous mutations in TYR, have no discernible pigmentation in hair, skin and eyes

  20. human tyrosinase, which can oxidize l-tyrosine but not d-tyrosine, was found to oxidize both R(-)- and S(+)-rhododendrol.

Mouse (Murine) Tyrosinase  (TYR) Interaktionspartner

  1. This study demonstrates the utility of CRISPR-Cas9 system in generating domain-specific in-frame deletions and helps gain further insights into structure-function of Tyr gene.

  2. These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.

  3. Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.

  4. STAP-2 colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.

  5. Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.

  6. Studied upregulation by Kaliziri extract of tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.

  7. The albino mutation of tyrosinase alters ocular angiogenic responsiveness.

  8. Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.

  9. activated by ascorbic acid in B16 melanoma via p38 MAPK signaling and upregulation of melanogenic regulatory factors

  10. Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells

  11. the schisis phenotype caused by the Rs1 mutation is rescued by a Tyr mutation in the C57BL/6J genetic background, strongly suggesting that Tyr is the Mor1 gene.

  12. Data suggest that accumulation of tyrosinase in the endoplasmic reticulum of melanocytes leads to ER stress and activation of the unfolded protein response.

  13. Data show that interfering with p38 MAPK expression stimulates melanogenesis and tyrosinase family protein expression.

  14. role of P protein and tyrosinase in oculocutaneous albinism

  15. processing is controlled by pink-eyed dilution protein

  16. identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype in developmental glaucoma

  17. Tyrosinase maturation and oligomerization in the endoplasmic reticulum require a melanocyte-specific factor

  18. investigation of the boundary activity of locus control regions in transgenic animals and cells

  19. tyrosinase has a role in fatty acid regulation of pigmentation

  20. Interactions between N-linked glycans and lectin chaperones help to minimize tyrosinase aggregation and also target non-native substrates for retro-translocation and subsequent degradation

Guinea Pig Tyrosinase  (TYR) Interaktionspartner

  1. the missense mutation (c.710A>G; p.Asp237Gly) in the TYR gene is associated with the albino phenotype in guinea pig

Rabbit Tyrosinase  (TYR) Interaktionspartner

  1. the 3' UTR of the rabbit Tyr gene was deleted by a dual sgRNA directed CRISPR/Cas9 system which resulted in gray coat color and reduced melanin in hair follicles and irises was found in the mutated rabbit.

  2. we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR), as well as genes with unknown functions.

Tyrosinase  (TYR) Antigen-Profil

Protein Überblick

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Genbezeichner und Symbole assoziert mit anti-Tyrosinase  (TYR) Antikörper

  • tyrosinase (tyr) Antikörper
  • TYRosinase (tyr-5) Antikörper
  • tyrosinase S homeolog (tyr.S) Antikörper
  • tyrosinase (TYR) Antikörper
  • tyrosinase (Celal_3121) Antikörper
  • tyrosinase (Halhy_4121) Antikörper
  • tyrosinase (Mesop_2736) Antikörper
  • tyrosinase (LOC100136546) Antikörper
  • tyrosinase (Tyr) Antikörper
  • albino Antikörper
  • C Antikörper
  • CMM8 Antikörper
  • LOC100136546 Antikörper
  • OCA1A Antikörper
  • OCAIA Antikörper
  • sandy Antikörper
  • SHEP3 Antikörper
  • skc35 Antikörper
  • tyr Antikörper
  • TYRO Antikörper
  • zgc:109705 Antikörper

Bezeichner auf Proteinebene für anti-Tyrosinase  (TYR) Antikörper

oca1 , sdy , tyra , hypothetical protein , tyrosinase (oculocutaneous albinism IA) , tyrosinase , monophenol monooxygenase , tyrosinase-like , LB24-AB , SK29-AB , oculocutaneous albinism IA , tumor rejection antigen AB , albino locus protein

GENE ID SPEZIES
30207 Danio rerio
189907 Caenorhabditis elegans
398715 Xenopus laevis
451473 Pan troglodytes
705792 Macaca mulatta
10145547 Cellulophaga algicola DSM 14237
10588308 Haliscomenobacter hydrossis DSM 1100
10826573 Mesorhizobium opportunistum WSM2075
100049427 Oryzias latipes
100125152 Xenopus (Silurana) tropicalis
100135825 Oncorhynchus mykiss
100136546 Salmo salar
100453479 Pongo abelii
100594055 Nomascus leucogenys
7299 Homo sapiens
22173 Mus musculus
308800 Rattus norvegicus
100713552 Cavia porcellus
403405 Canis lupus familiaris
751100 Felis catus
100008753 Oryctolagus cuniculus
407745 Sus scrofa
280951 Bos taurus
373971 Gallus gallus
780502 Ovis aries
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