Tumor Susceptibility Gene 101 Proteine (TSG101)

The protein encoded by TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. Zusätzlich bieten wir Ihnen TSG101 Antikörper (125) und TSG101 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TSG101 7251 Q99816
TSG101 22088 Q61187
Ratte TSG101 TSG101 292925 Q6IRE4
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 20 Days
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 25 bis 30 Tage
Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days

TSG101 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Tumor Susceptibility Gene 101 (TSG101) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Tumor Susceptibility Gene 101 (TSG101) Interaktionspartner

  1. loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept

  2. analysis of genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor

Human Tumor Susceptibility Gene 101 (TSG101) Interaktionspartner

  1. Results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag.

  2. our studies reveal that Tsg101 plays a role in the trafficking of macropinocytosed Kaposi's sarcoma-associated herpesvirus in the endothelial cells

  3. Knockdown of LAMP2A, a CMA-related protein, and TSG101, an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH (zeige GAPDH Proteine)-HT in AD293 cells and primary cultured rat cortical neurons.

  4. the variant alleles of TSG101 rs2292179 and ATF2 (zeige ATF2 Proteine) rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively

  5. TSGDelta154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.

  6. Results show that TSG101 bidirectionally modulates cell invasion through regulating MMP-9 (zeige MMP9 Proteine) mRNA expression in different cell types.

  7. TSG101 plays an important role in the development of hepatocellular carcinoma

  8. Expression of tsg101 mRNA and of TSG101 protein were significantly higher in the oxaliplatin resistant cell line than parent HT-29 cels.

  9. PSAP (zeige PSAP Proteine) motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.

  10. Stress-internalized EGFR (zeige EGFR Proteine) is retained intracellularly by continued p38 (zeige CRK Proteine) activity in a mechanism involving ubiquitin-independent, ESCRT/ALIX (zeige PDCD6IP Proteine)-dependent incorporation onto intraluminal vesicles (ILVs (zeige IARS Proteine)) of MVBs

Mouse (Murine) Tumor Susceptibility Gene 101 (TSG101) Interaktionspartner

  1. Tsg101 was deleted from mature oligodendroglia in vivo. This resulted in severe spongiform encephalopathy, histopathologically similar to that observed in Mgrn1 (zeige MGRN1 Proteine) null mutant mice but with a more rapid onset.

  2. BLOS1 (zeige BLOC1S1 Proteine) interacts with sorting nexin 2 (zeige SNX2 Proteine) and the ESCRT-I (zeige VPS28 Proteine) component TSG101 to mediate the sorting of EGFR (zeige EGFR Proteine) into endosomal compartments

  3. pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.

  4. Tsg101 has a role in expression of EGFR (zeige EGFR Proteine) and ErbB2 (zeige ERBB2 Proteine) and preventing induction of autophagy prior to cell death

  5. show that ubiquitin recognition by TSG101 is required for cSMAC formation, T cell receptor (TCR) microcluster signal termination, TCR downregulation.

  6. Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1 (zeige CDKN1A Proteine)).

  7. Targeted deletion results in cell cycle arrest and p53 (zeige TP53 Proteine)-independent cell death

  8. our results suggest that Tsg101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer.

  9. the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes

  10. the Tsg101 protein has only weak oncogenic properties

TSG101 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

Genbezeichner und Symbole assoziert mit TSG101

  • tumor susceptibility 101 (TSG101)
  • Tumor susceptibility gene 101 (TSG101)
  • Tumor Susceptibility Gene homolog (tsg-101)
  • tumor susceptibility 101 (tsg101)
  • tumor susceptibility gene 101 (Tsg101)
  • tumor susceptibility gene 101 (TSG101)
  • tumor susceptibility 101 (Tsg101)
  • tumor susceptibility 101a (tsg101a)
  • tumor susceptibility 101 L homeolog (tsg101.L)
  • AI255943 Protein
  • burs Protein
  • CC2 Protein
  • CG9712 Protein
  • Dmel\\CG9712 Protein
  • DmTSG101 Protein
  • dTsg101 Protein
  • dVps23 Protein
  • ept Protein
  • ESCRT-I Protein
  • MGC76193 Protein
  • Rw Protein
  • TSG10 Protein
  • TSG101 Protein
  • VPS23 Protein
  • zgc:86926 Protein

Bezeichner auf Proteinebene für TSG101

CG9712-PA , TSG101-PA , erupted , tumor susceptibility Gene-101 , Tumor Susceptibility Gene homolog family member (tsg-101) , ESCRT-I complex subunit TSG101 , tumor susceptibility gene 101 protein , tumor susceptibility protein 101 , tumor susceptibility gene 101 , tumor susceptibility gene 10 , tumor susceptibility protein , Tumor supressor

100057099 Equus caballus
39881 Drosophila melanogaster
182474 Caenorhabditis elegans
693787 Macaca mulatta
451065 Pan troglodytes
394879 Xenopus (Silurana) tropicalis
100172234 Pongo abelii
7251 Homo sapiens
22088 Mus musculus
423082 Gallus gallus
485406 Canis lupus familiaris
507659 Bos taurus
292925 Rattus norvegicus
415179 Danio rerio
446571 Xenopus laevis
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