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TP63 encodes a member of the p53 family of transcription factors. Zusätzlich bieten wir Ihnen p63 Antikörper (77) und p63 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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the strong repression of Np63 by H-RAS (zeige HRAS ELISA Kits) and PIK3CA (zeige PIK3CA ELISA Kits) and induction of EMT (zeige ITK ELISA Kits) suggest that this process is critical for mammary tumorigenesis.
This study suggests that in patients with CD30 (zeige TNFRSF8 ELISA Kits)+ lymphoproliferative disorders, an aggressive clinical course cannot be defined by the presence of TP63 rearrangements, as was recently shown in systemic ALK (zeige ALK ELISA Kits) negative anaplastic large cell lymphoma.
This study revealed the possible association between TP63 and Mullerian duct anomalies and suggested a potential contribution of microRNA-regulated expression of genes in the etiology of Mullerian duct anomalies.
We identified a list of thirty genes repressed by DeltaNp63 in a SETDB1 (zeige SETDB1 ELISA Kits)-dependent manner, whose expression is positively correlated to survival of breast cancer patients. These results suggest that p63 (zeige RPE65 ELISA Kits) and SETDB1 (zeige SETDB1 ELISA Kits) expression, together with the repressed genes, may have diagnostic and prognostic potential
Dysregulation of JAM-A (zeige F11R ELISA Kits) via p63 (zeige RPE65 ELISA Kits)/GATA-3 (zeige GATA3 ELISA Kits) signaling pathway occurs in squamous cell carcinomas of the head and neck.
This study investigated the expression of p40 (zeige IL9 ELISA Kits) protein in meningiomas and explored its usefulness as prognostic marker in addition to PgR (zeige PGR ELISA Kits) and Ki67 (zeige MKI67 ELISA Kits).
the transactivation inhibitory (TI) domains within the alpha-isoform-specific C termini of p63 (zeige RPE65 ELISA Kits) and p73 (zeige TP73 ELISA Kits) are essential for binding to p53R175H.
Data show that a two-marker panel of p40 (zeige IL9 ELISA Kits) (DeltaNp63) and CDX2 (zeige CDX2 ELISA Kits) is highly sensitive and specific.
DeltaNp63alpha (TP63) is co-expressed with FAT2 and Slug in patient tumors and the elevated expression of DeltaNp63alpha, FAT2 and Slug correlated with poor patient outcome.
Keratin14/p63 (zeige RPE65 ELISA Kits)-positive epithelial proliferations suggest benign breast disease.
p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses
they unravel essential roles of TAp63 and p53 (zeige TP53 ELISA Kits) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (zeige NOTCH1 ELISA Kits) signalling and caspase 3 (zeige CASP3 ELISA Kits) activity.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (zeige BBC3 ELISA Kits) transcription in response to ER stress.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
rps19 (zeige RPS19 ELISA Kits)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (zeige TP53 ELISA Kits) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (zeige IL31 ELISA Kits) and IL-33 (zeige IL33 ELISA Kits) are key players in the signaling pathways.
cells expressing both p63 (zeige CKAP4 ELISA Kits) and p73 (zeige ARHGAP24 ELISA Kits) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
Data suggest that this the selective targeting of genes by tumor suppressor protein (zeige TP53 ELISA Kits) p63 (p63 (zeige CKAP4 ELISA Kits)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 ELISA Kits) expression via E2F1 transcription factor (zeige E2F1 ELISA Kits) 1 (zeige HNF1A ELISA Kits), promoting Wasf3/Wave3 (zeige WASF3 ELISA Kits)/MMP9 (zeige MMP9 ELISA Kits) signaling and bladder cancer invasion
these results therefore highlight an unanticipated role for p53 (zeige TP53 ELISA Kits) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 ELISA Kits)-Tcf (zeige HNF4A ELISA Kits) and nodal-Smad (zeige SMAD1 ELISA Kits) inputs.
the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (zeige TP53 ELISA Kits) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.
TGFb3 (zeige TGFB3 ELISA Kits)-induced down-regulation of p63 (zeige CKAP4 ELISA Kits) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.
miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.
Taken together, these data show that p63 (zeige CKAP4 ELISA Kits) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.
IL-6 (zeige IL6 ELISA Kits)/P-STAT3 (zeige STAT3 ELISA Kits) activation influences p63 (zeige CKAP4 ELISA Kits) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (zeige BMP4 ELISA Kits).
The role of p63 as a negative Wnt (zeige WNT2 ELISA Kits)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, tumor protein p63
, transformation related protein 63
, tumor protein 63 kDa
, tumor protein 63-like