Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteine (TNFAIP8L2)

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Antikörper (63) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFAIP8L2 69769 Q9D8Y7
Ratte TNFAIP8L2 TNFAIP8L2 310663 Q6AYJ8
TNFAIP8L2 79626 Q6P589
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Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
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Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Primaten His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Rhinoceros His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Callithrix jacchus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,442.00
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,442.00
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TNFAIP8L2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartner

  1. TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells.

  2. TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea.

  3. Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha (zeige TNF Proteine), TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha (zeige TNF Proteine) and TIPE2 might be potential targets for the successfully grafted corneal endothelium.

  4. the enhancement of stat3 (zeige STAT3 Proteine) phosphorylation and decrease of LPS (zeige TLR4 Proteine)-induced p65 (zeige NFkBP65 Proteine) translocation were achieved by nicotine treatment..this study revealed that TIPE2 upregulation and stat3 (zeige STAT3 Proteine) phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 (zeige STAT3 Proteine) might be potential molecules for dealing with inflammation-associated diseases.

  5. TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target.

  6. Results suggest that tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2) appeared to be a critical immunoregulatory molecule which affected dendritic cells (DCs) maturation and subsequent T-cell mediated immunity.

  7. The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis.

  8. TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8 (zeige CD8A Proteine)(+) T and NK cell-mediated antitumor immune responses

  9. Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 (zeige IL4 Proteine) induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT (zeige AKT1 Proteine) signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages.

  10. The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 (zeige NR2C2 Proteine) signaling.

Human Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartner

  1. The results of the present study indicated that TIPE2 acts as an inhibitor of hepatocellular carcinoma cell growth and aggressiveness, and promotes apoptosis, thus suggesting that TIPE2 may inhibit the metastasisassociated PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling cascade and may arrest the tumor cell cycle.

  2. The expression of TIPE2 in THP1 cells may be upregulated by Poly I:C.

  3. In conclusion, for the first time, we discovered that the Th2 milieu is able to upregulate TIPE2 expression in macrophages, which facilitates the change in macrophage phenotype and function and, in turn, potentially exaggerates eosinophilic inflammation and disease progression in chronic rhinosinusitis with nasal polyps.

  4. TIPE2 may participate in T2DM by regulating TNF-alpha (zeige TNF Proteine) production

  5. Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha (zeige TNF Proteine), TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha (zeige TNF Proteine) and TIPE2 might be potential targets for the successfully grafted corneal endothelium.

  6. TIPE2 inhibited the expression of asthma-related inflammatory factors in hyperstretched BEAS-2B cells by suppressing the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.

  7. TIPE2 might be associated with immune clearance of patients with chronic hepatitis B.

  8. TIPE2 could play important roles in maintaining the maternal-fetal tolerance and decreased TIPE2 expression in the decidua may be related to the development of missed abortion.

  9. TIPE2 suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF (zeige VEGFA Proteine) expression.

  10. the expression of TIPE2 protein could be a predictor of better prognosis for DLBCL.

Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Protein Überblick

Protein Überblick

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Genbezeichner und Symbole assoziert mit TNFAIP8L2

  • tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2)
  • TNF alpha induced protein 8 like 2 (Tnfaip8l2)
  • TNF alpha induced protein 8 like 2 (TNFAIP8L2)
  • Tumor necrosis factor, alpha-induced protein 8-like protein 2 (tp8l2)
  • TNF alpha induced protein 8 like 2 L homeolog (tnfaip8l2.L)
  • tumor necrosis factor, alpha-induced protein 8-like 2a (tnfaip8l2a)
  • TNF alpha induced protein 8 like 2 S homeolog (tnfaip8l2.S)
  • 1810019A08Rik Protein
  • AW610835 Protein
  • RGD1310519 Protein
  • tipe2 Protein
  • TIPE2 A Protein
  • tnfaip8l2 Protein
  • tnfaip8l2-a Protein
  • tnfaip8l2-b Protein
  • tnfaip8l2b Protein
  • zgc:136816 Protein

Bezeichner auf Proteinebene für TNFAIP8L2

TNF alpha-induced protein 8-like protein 2 , TNFAIP8-like protein 2 , tumor necrosis factor alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 , TIPE2 , inflammation factor 20 , inflammation factor protein 20 , Tumor necrosis factor, alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 a , TIPE2 B , TNF alpha-induced protein 8-like protein 2 A , TNFAIP8-like protein 2 A , TNFAIP8-like protein 2 B , tumor necrosis factor, alpha-induced protein 8-like 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 A , tumor necrosis factor, alpha-induced protein 8-like protein 2 B , TNF alpha induced protein 8 like 2 S homeolog , tumor necrosis factor, alpha-induced protein 8-like protein 2 b

GENE ID SPEZIES
69769 Mus musculus
310663 Rattus norvegicus
79626 Homo sapiens
510652 Bos taurus
100328663 Oryctolagus cuniculus
100195718 Salmo salar
399018 Xenopus laevis
723996 Danio rerio
100732897 Cavia porcellus
734764 Xenopus laevis
483192 Canis lupus familiaris
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