Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteine (TNFAIP8L2)

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Antikörper (66) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNFAIP8L2 69769 Q9D8Y7
Ratte TNFAIP8L2 TNFAIP8L2 310663 Q6AYJ8
TNFAIP8L2 79626 Q6P589
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Primaten His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Rhinoceros His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Callithrix jacchus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,442.00
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Hefe REACT_Atlantic Salmon His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,442.00
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TNFAIP8L2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartnern

Mouse (Murine) Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartner

  1. TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells.

  2. TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea.

  3. Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.

  4. the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment..this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases.

  5. TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target.

  6. Results suggest that tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2) appeared to be a critical immunoregulatory molecule which affected dendritic cells (DCs) maturation and subsequent T-cell mediated immunity.

  7. The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis.

  8. TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8(+) T and NK cell-mediated antitumor immune responses

  9. Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages.

  10. The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling.

  11. Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2) gene was down-regulated, the expression of the CD69 antigen was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma were enhanced.

  12. TIPE2 alleviates experimental SLE through induction of macrophage polarization to a M2 phenotype, which may be used as a promising therapeutic strategy for treating SLE.

  13. TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses.

  14. TIPE2 plays a suppressive role in injury-induced restenosis and may serve as a new therapeutic target for treating the disease.

  15. Tipe2 provides a molecular bridge between miR-21 and cell apoptosis; miR-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2.

  16. TIPE2 deficiency in hematopoietic cells ameliorates experimental colitis; TIPE2 is a negative regulator of antibacterial immunity, indicating that TIPE2 promotes colitis by inhibiting mucosal immunity to commensal bacteria.

  17. TIPE2 plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein.

  18. study reports that TIPE2, the tumor necrosis factor-alpha-induced protein 8-like 2, plays an atheroprotective role by regulating phenotypic switching of vascular smooth muscle cells in response to oxidized low-density lipoprotein stimuli

  19. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

  20. TIPE2 plays an essential role in a signal transduction pathway that links the inflammatory immune response to specific conditions after cerebral ischemia.

Human Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaktionspartner

  1. Reduced TIPE2 expression is inversely associated with proinflammatory cytokines and positively correlated with bone mineral density in patients with osteoporosis

  2. Our results demonstrated that TIPE2 is a novel tumor suppressor gene that inhibits GC growth may mediated via AKT and IkappaBalpha phosphorylated activation.

  3. Low TIPE2 expression is associated with Gastric cancer.

  4. The results of the present study indicated that TIPE2 acts as an inhibitor of hepatocellular carcinoma cell growth and aggressiveness, and promotes apoptosis, thus suggesting that TIPE2 may inhibit the metastasisassociated PI3K/AKT signaling cascade and may arrest the tumor cell cycle.

  5. The expression of TIPE2 in THP1 cells may be upregulated by Poly I:C.

  6. In conclusion, for the first time, we discovered that the Th2 milieu is able to upregulate TIPE2 expression in macrophages, which facilitates the change in macrophage phenotype and function and, in turn, potentially exaggerates eosinophilic inflammation and disease progression in chronic rhinosinusitis with nasal polyps.

  7. TIPE2 may participate in T2DM by regulating TNF-alpha production

  8. Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.

  9. TIPE2 inhibited the expression of asthma-related inflammatory factors in hyperstretched BEAS-2B cells by suppressing the Wnt/beta-catenin signaling pathway.

  10. TIPE2 might be associated with immune clearance of patients with chronic hepatitis B.

  11. TIPE2 could play important roles in maintaining the maternal-fetal tolerance and decreased TIPE2 expression in the decidua may be related to the development of missed abortion.

  12. TIPE2 suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF expression.

  13. Further MD simulations confirmed the dynamic stability of these lipids in the TH domain. This computational analysis thus provides insight into the binding mode of phospholipids in the TH domain of the TIPE family of proteins.

  14. the expression of TIPE2 protein could be a predictor of better prognosis for DLBCL.

  15. Insufficient expression of TIPE2 might be involved in the hyperreactivity of monocyte to Toll-like receptor ligands in primary biliary cirrhosis.

  16. data provided the first evidence that TIPE2 inhibits gastric cancer cell migration, invasion and metastasis very probably via reversal of EMT, revealing that TIPE2 may be a novel therapeutic target for human gastric cancer EMT and metastasis.

  17. Authors demonstrated that TIPE2 overexpression may suppress proliferation, migration, and invasion in prostate cancer cells by inhibiting the PI3K/Akt signaling pathway.

  18. TIPE2 suppressed breast cancer tumorigenesis, growth and metastasis possibly via regulation of the AKT and p38 signaling pathways.

  19. these data suggest that TIPE2 overexpression inhibited hypoxia-induced Wnt/beta-catenin pathway activation and EMT in glioma cells.

  20. this study shows that TIPE2 contributes to the pathogenesis of ankylosing spondylitis

Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Protein Überblick

Protein Überblick

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Genbezeichner und Symbole assoziert mit TNFAIP8L2

  • tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2)
  • TNF alpha induced protein 8 like 2 (Tnfaip8l2)
  • TNF alpha induced protein 8 like 2 (TNFAIP8L2)
  • Tumor necrosis factor, alpha-induced protein 8-like protein 2 (tp8l2)
  • TNF alpha induced protein 8 like 2 L homeolog (tnfaip8l2.L)
  • tumor necrosis factor, alpha-induced protein 8-like 2a (tnfaip8l2a)
  • TNF alpha induced protein 8 like 2 S homeolog (tnfaip8l2.S)
  • 1810019A08Rik Protein
  • AW610835 Protein
  • RGD1310519 Protein
  • tipe2 Protein
  • TIPE2 A Protein
  • tnfaip8l2 Protein
  • tnfaip8l2-a Protein
  • tnfaip8l2-b Protein
  • tnfaip8l2b Protein
  • zgc:136816 Protein

Bezeichner auf Proteinebene für TNFAIP8L2

TNF alpha-induced protein 8-like protein 2 , TNFAIP8-like protein 2 , tumor necrosis factor alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 , TIPE2 , inflammation factor 20 , inflammation factor protein 20 , Tumor necrosis factor, alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 a , TIPE2 B , TNF alpha-induced protein 8-like protein 2 A , TNFAIP8-like protein 2 A , TNFAIP8-like protein 2 B , tumor necrosis factor, alpha-induced protein 8-like 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 A , tumor necrosis factor, alpha-induced protein 8-like protein 2 B , TNF alpha induced protein 8 like 2 S homeolog , tumor necrosis factor, alpha-induced protein 8-like protein 2 b

GENE ID SPEZIES
69769 Mus musculus
310663 Rattus norvegicus
79626 Homo sapiens
510652 Bos taurus
100328663 Oryctolagus cuniculus
100195718 Salmo salar
399018 Xenopus laevis
723996 Danio rerio
100732897 Cavia porcellus
734764 Xenopus laevis
483192 Canis lupus familiaris
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