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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid.
Showing 10 out of 22 products:
Human Polyclonal WARS2 Primary Antibody für IP, WB - ABIN948928
Miyanokoshi, Tanaka, Tamai, Tagawa, Wakasugi: Expression of the rodent-specific alternative splice variant of tryptophanyl-tRNA synthetase in murine tissues and cells. in Scientific reports 2013
Cow (Bovine) Polyclonal WARS2 Primary Antibody für WB - ABIN2774013
Guo, Chen, Zhao, Shi, Li, Xue, Jin: Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. in Nucleic acids research 2007
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Human Polyclonal WARS2 Primary Antibody für WB - ABIN4890285
Wang, Sips, Khin, Rotival, Sun, Ahmed, Widjaja, Schafer, Yusoff, Choksi, Ko, Singh, Epstein, Guan, Houštěk, Mracek, Nuskova, Mikell, Tan, Pesce, Kolar, Bottolo, Mancini, Hubner, Pravenec, Petretto et al.: Wars2 is a determinant of angiogenesis. ... in Nature communications 2016
This confidently implicates that mutations in WARS2 cause mitochondrial disease with a broad spectrum of clinical presentation.
we found a compound heterozygous genotype of the mitochondrial tryptophanyl-tRNA synthetase (WARS2) gene, comprising a nonsense mutation (c.325delA, p.Ser109Alafs*15), which very likely entails nonsense-mediated mRNA decay and a missense mutation
Here we substantially extend and consolidate the symptomatology of WARS2 by presenting a patient with severe infantile-onset leukoencephalopathy, profound intellectual disability, spastic quadriplegia, epilepsy, microcephaly, short stature, failure to thrive, cerebral atrophy, and periventricular white matter abnormalities
first genome-wide scan for selection in Inuit from Greenland. A region, with a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome contains two genes, WARS2 and TBX15 (zeige TBX15 Antikörper). our study suggests a complex multi-factorial regulation of TBX15 (zeige TBX15 Antikörper) and WARS2. We show that the introgressed region is associated with regional changes in methylation and expression levels
tandem promoters provide a dual system to regulate expression and alternative splicing of human TrpRS (zeige WARS Antikörper) in vivo
Mutations located at the appended beta1-beta2 hairpin and the AIDQ sequence of human TrpRS (zeige WARS Antikörper) switch this enzyme to a tRNA-dependent mode in the tryptophan activation step.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
tryptophanyl tRNA synthetase 2, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial-like
, tryptophan--tRNA ligase, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial
, tryptophan tRNA ligase 2, mitochondrial
, tryptophan-tRNA ligase
, mitochondrial tryptophanyl-tRNA synthetase 2
, tryptophanyl tRNA synthetase 2 (mitochondrial)