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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Zusätzlich bieten wir Ihnen WARS2 Proteine (41) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 23 products:
Human Polyclonal WARS2 Primary Antibody für IP, WB - ABIN948928
Miyanokoshi, Tanaka, Tamai, Tagawa, Wakasugi: Expression of the rodent-specific alternative splice variant of tryptophanyl-tRNA synthetase in murine tissues and cells. in Scientific reports 2013
Cow (Bovine) Polyclonal WARS2 Primary Antibody für WB - ABIN2774013
Guo, Chen, Zhao, Shi, Li, Xue, Jin: Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. in Nucleic acids research 2007
Show all 2 Pubmed References
Human Polyclonal WARS2 Primary Antibody für WB - ABIN4890285
Wang, Sips, Khin, Rotival, Sun, Ahmed, Widjaja, Schafer, Yusoff, Choksi, Ko, Singh, Epstein, Guan, Houštěk, Mracek, Nuskova, Mikell, Tan, Pesce, Kolar, Bottolo, Mancini, Hubner, Pravenec, Petretto et al.: Wars2 is a determinant of angiogenesis. ... in Nature communications 2016
The data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart.
An alternative conformation of human TrpRS (zeige WARS Antikörper) suggests a role of zinc in activating non-enzymatic function.
This confidently implicates that mutations in WARS2 cause mitochondrial disease with a broad spectrum of clinical presentation.
we found a compound heterozygous genotype of the mitochondrial tryptophanyl-tRNA synthetase (WARS2) gene, comprising a nonsense mutation (c.325delA, p.Ser109Alafs*15), which very likely entails nonsense-mediated mRNA decay and a missense mutation
Here we substantially extend and consolidate the symptomatology of WARS2 by presenting a patient with severe infantile-onset leukoencephalopathy, profound intellectual disability, spastic quadriplegia, epilepsy, microcephaly, short stature, failure to thrive, cerebral atrophy, and periventricular white matter abnormalities
first genome-wide scan for selection in Inuit from Greenland. A region, with a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome contains two genes, WARS2 and TBX15 (zeige TBX15 Antikörper). our study suggests a complex multi-factorial regulation of TBX15 (zeige TBX15 Antikörper) and WARS2. We show that the introgressed region is associated with regional changes in methylation and expression levels
tandem promoters provide a dual system to regulate expression and alternative splicing of human TrpRS (zeige WARS Antikörper) in vivo
Mutations located at the appended beta1-beta2 hairpin and the AIDQ sequence of human TrpRS (zeige WARS Antikörper) switch this enzyme to a tRNA-dependent mode in the tryptophan activation step.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.
tryptophanyl tRNA synthetase 2, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial-like
, tryptophan--tRNA ligase, mitochondrial
, tryptophanyl-tRNA synthetase, mitochondrial
, tryptophan tRNA ligase 2, mitochondrial
, tryptophan-tRNA ligase
, mitochondrial tryptophanyl-tRNA synthetase 2
, tryptophanyl tRNA synthetase 2 (mitochondrial)