anti-Tryptophan Hydroxylase 2 (TPH2) Antikörper

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Zusätzlich bieten wir Ihnen Tryptophan Hydroxylase 2 Kits (29) und Tryptophan Hydroxylase 2 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TPH2 121278 Q8IWU9
TPH2 317675 Q8CGU9
TPH2 216343 Q8CGV2
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (ff), IHC (p), IP, WB Immunoprecipitation: Tryptophan hydroxylase 2 Antibody [ABIN2616435] - Analysis of raphe nuclei isolated from Sprague-Dawley rat brains using TPH2 Polyclonal Antibody. PA1-778 was coupled to magnetic beads and added to raphe nuclei whole cell extracts for 15 minutes at RT. Immunoprecipitated proteins were assessed by Western blotting (WB), using either mouse anti-TPH2 (Ms TPH2, Lane 2) or sheep anti-TPH2 antibodies (Sh TPH2, Lane 3). As a positive control for the Western blot, non-immunoprecipitated brain lysates were probed with the mouse anti-TPH2 antibody (Lane 1). As a specificity control, a blot containing immunoprecipitated proteins was probed with an antibody specific for Tyrosine Hydroxylase (TH, Lane 4). Data courtesy of the Innovators Program. Immunocytochemistry/Immunofluorescence: Tryptophan hydroxylase 2 Antibody [ABIN2616435] - Analysis in mouse brain cells. Image courtesy of product review by Assaf Vestin. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$516.98
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TPH2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:500  Positive Control:  Human brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TPH2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, IHC   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
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Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
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Maus Ziege Unkonjugiert ELISA, IHC   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Maus Unkonjugiert IHC Immunohistochemistry-Paraffin: Tryptophan hydroxylase 2 Antibody (2990)  - Analysis of human kidney shows absence of immunoreactivity (negative control). Immunohistochemistry-Paraffin: Tryptophan hydroxylase 2 Antibody (2990)  - Staining of human cerebral cortex shows immunoreactivity in serotonergic fibers. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of TPH2 Antibody (Center) (ABIN653124) in 293 cell line lysates (35 µg/lane). TPH2 (arrow) was detected using the purified polyclonal antibody. TPH2 Antibody (Center) (ABIN653124) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert WB WB Image TPH2 antibody detects TPH2 protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with TPH2 antibody , diluted by 1:1000. 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Maus Ziege Unkonjugiert ELISA, WB Immunohistochemistry (0.5μg/ml) staining of paraffin embedded Mouse Brain stem in sagittal (left) and coronal (right) sections of Raphe nuclei. Detection Alexa 594. Data obtained from Prof. D Crane, Griffith Univeristy, Brisbane, Australia 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details

Am meisten referenzierte anti-Tryptophan Hydroxylase 2 Antikörper

  1. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für ICC, IF - ABIN261643 : Sullivan, Grayson, Takahashi, Robertson, Maier, Bethea, Smith, Coleman, Grove: Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 18 Pubmed References

  2. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für WB - ABIN550168 : Martínez, Knappskog, Haavik: A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. in Current medicinal chemistry 2001 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für IHC (p), IHC - ABIN250870 : Zhou, Roy, Lipsky, Kuchipudi, Zhu, Taubman, Enoch, Virkkunen, Goldman: Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. in Archives of general psychiatry 2005 (PubMed)

  4. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für WB - ABIN2778284 : Tzvetkov, Brockmöller, Roots, Kirchheiner: Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. in Pharmacogenetics and genomics 2008 (PubMed)

  5. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für WB - ABIN2778285 : Walther, Peter, Bashammakh, Hörtnagl, Voits, Fink, Bader: Synthesis of serotonin by a second tryptophan hydroxylase isoform. in Science (New York, N.Y.) 2003 (PubMed)

  6. Rat (Rattus) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für WB - ABIN361498 : Matsuo, Izumi, Wakita, Kume, Takada-Takatori, Sawada, Akaike: Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: implication of inhibition of vesicular transport. in European journal of pharmacology 2010 (PubMed)

  7. Mouse (Murine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody für ELISA, IHC - ABIN768606 : Rahim, Meedeniya, Crane: Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome. in Neuroscience 2014 (PubMed)

Weitere Antikörper gegen Tryptophan Hydroxylase 2 Interaktionspartner

Human Tryptophan Hydroxylase 2 (TPH2) Interaktionspartner

  1. These findings indicate that TPH1, TPH2, and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

  2. results provide new evidence for the role of regulatory genetic variants that could modulate human TPH2 expression in the antidepressant response to fluoxetine.

  3. This study firstly demonstrated evidence for an association between aberrant cortical folding in the PFC and ACC and TPH2 polymorphism gene related to the pathophysiology of major depressive disorder.

  4. This study shown that theTPH2 genotype is likely to modulate the risk for addictive behaviors in PD on dopaminergic therapy.

  5. social anxiety disorder entails an overactive presynaptic serotonergic system that, in turn, seems functionally influenced by the TPH2 G-703T polymorphism in emotionally relevant brain regions

  6. nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed.

  7. Tryptophan hydroxylase synthesizes Serotonin and is over-expressed in Suicides.TPH2 mRNA was greater in Suicide Nonsmokers than Suicide Smokers.The absence of altered TPH2 expression in non-suicide smokers suggests no pharmacological effect of Smoking.

  8. This study shown the significant results were found with TPH2 rs4570625 involved with fast visual processing as assessed by metacontrast.

  9. Genetic variation in TPH2 is associated with antidepressant response and may also interact with childhood trauma to influence outcome of antidepressant treatment.

  10. 2-way interaction between TPH2 rs4290270 and general traumas revealed that TT homozygotes with history of general traumas had an increased risk for suicide attempt. 3-way interaction of general traumas, TPH2 rs4290270 and ADARB1 rs4819035 indicated that highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035.

  11. The catalytic domain of TPH1 shares a sequence identity of 81% with TPH2. Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 displays substrate tryptophan inhibition.

  12. results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior.

  13. There was no association between rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene and major depressive disorder in a sample of the Colombian population

  14. This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.

  15. This study provides the first evidence that, at least among Han Chinese patients with PD, AC genotype at rs78162420 in the TPH2 gene increase risk of depression.

  16. interaction between SNP rs4570625 and BDNF Val66Met predicts a high-Risk emotional phenotype

  17. Subjects with the TPH2 rs4570625 TT genotype, especially males, exhibit less aggression and a favourable impulsivity profile, and develop anxiety disorders by young adulthood less often

  18. Study reports an association between functional variation on the TPH2 promotor region and rich club-a densely mutually connected set of hub regions in the brain, thought to serve as a processing and integration core-organization

  19. Altered TPH2 expression in colonic serotonergic nerves of patients with Hirschsprung's disease complicated by enterocolitis may contribute to intestinal secretory and motor disturbances, including recurrent HAEC.

  20. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population. In single marker analyses,there was a significant difference in the genotype (chi (2) = 4.163, P = 0.041) and allele frequency (chi (2) = 3.930, P = 0.047) of rs1386494 between ODD and control groups.

Rhesus Monkey Tryptophan Hydroxylase 2 (TPH2) Interaktionspartner

  1. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys

  2. The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT metabolism, HPA axis function, and aggressive behaviors

  3. Study identified 17 single nucleotide polymorphisms; 3'-UTR polymorphisms were significantly associated with HPA axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.

  4. functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2

Chimpanzee Tryptophan Hydroxylase 2 (TPH2) Interaktionspartner

  1. Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.

Zebrafish Tryptophan Hydroxylase 2 (TPH2) Interaktionspartner

  1. these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.

  2. tphR is expressed in serotonergic raphe neurons, similar to tph genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin

Mouse (Murine) Tryptophan Hydroxylase 2 (TPH2) Interaktionspartner

  1. The Tph2(-/-) mice showed deficiency in brain 5-HT increases the functional coupling of 5-HT1AARs to GIRK channels without a concomitant increase in 5-HT1AAR and/or GIRK channel density level.

  2. Results indicate that Tph2 knockout affected the ability of olfactory recognition rather than olfactory discrimination. For the first time, reproductive experiences have been shown to mitigate the disruptive effect of Tph2 knockout on the sexual olfactory preference of female mice. Furthermore, ERalpha and OTR activation might constitute the neural substrates that are involved involved in the facilitative mechanisms.

  3. the first experimental evidence that C1473G polymorphism is involved in the regulation of the reaction to emotional stress in mice.

  4. This study demonstrated that tryptophan hydroxylase 2 Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.

  5. No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice

  6. the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.

  7. The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT-dependent mechanisms in psychostimulants action.

  8. both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion

  9. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D.

  10. Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.

  11. Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin

  12. This study showed that optogenetic activation of tryptophan hydroxylase 2-expressing serotonergic neurons in rostral ventromedial medulla in vivo induces a long-lasting pain sensitization measured as mechanical allodynia and thermal hyperalgesia. I

  13. While total cell density in the anterior basolateral amygdala did not differ between genotypes, the number and density of the GABAergic interneurons were significantly decreased in Tph2(-/-) mice.

  14. Females exhibit increased sensitivity to at least some of the effects of congenital 5-HT deficiency.

  15. The data of this study suggested that adolescent social isolation alters tph2 expression in specific subregions of the DR and alters the effects of stress-related stimuli on behavior and serotonergic systems.

  16. This study revealed that lifelong depletion in Tph2-/- mice had no measurable change in baseline proliferation when compared with WT mice at different ages.

  17. BDNF induces increase of brain 5-HT serotonin system functional activity andtryptophan hydroxylase (Tph)-2, 5-HT1A and 5-HT2A gene expression and 5-HT2A receptor functional activity in a mouse model of hereditary behavior disorders

  18. In this study, we report that TPH2 transcript and protein are modulated by neuronal differentiation in the cell line A1 mes-c-myc (A1).

  19. low CSF 5-HIAA and a blunted fenfluramine-induced prolactin response, also blunted 5-HT1A agonist-induced hypothermia and increased 5-HT2A receptor levels are bona fide biomarkers of chronic,endogenous 5-HT deficiency.

  20. This study demonistrated that tph2 gene expression in mouse dorsal raphe nucleus.

Tryptophan Hydroxylase 2 (TPH2) Antigen-Profil

Protein Überblick

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Genbezeichner und Symbole assoziert mit TPH2

  • tryptophan hydroxylase 2 (TPH2) Antikörper
  • tryptophan hydroxylase 2 (Tph2) Antikörper
  • tryptophan hydroxylase 2 (tph2) Antikörper
  • tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) (tph2) Antikörper
  • ADHD7 Antikörper
  • AU043594 Antikörper
  • Ntph Antikörper
  • tphR Antikörper
  • wu:fq15a04 Antikörper

Bezeichner auf Proteinebene für TPH2

neuronal tryptophan hydroxylase , tryptophan 5-hydroxylase 2 , tryptophan 5-monooxygenase 2 , tryptophan hydroxylase-2 , tryptophan hydroxylase 2 , tryptophan 5-hydroxylase 2-like , tph2a , tryptophan hydroxylase R

GENE ID SPEZIES
121278 Homo sapiens
664730 Macaca mulatta
317675 Rattus norvegicus
408026 Gallus gallus
467070 Pan troglodytes
481165 Canis lupus familiaris
100009684 Equus caballus
100303678 Meleagris gallopavo
100459809 Pongo abelii
100486097 Xenopus (Silurana) tropicalis
100588345 Nomascus leucogenys
407712 Danio rerio
216343 Mus musculus
100627725 Sus scrofa
100336620 Bos taurus
100724594 Cavia porcellus
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