anti-Tryptophan 2,3-Dioxygenase (TDO2) Antikörper

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human TDO2 TDO2 6999 P48775
Anti-Maus TDO2 TDO2 56720 P48776
Anti-Ratte TDO2 TDO2 64206 P21643
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Top anti-Tryptophan 2,3-Dioxygenase Antikörper auf antikoerper-online.de

Showing 10 out of 61 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-TDO2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TDO2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Small Intestine Host:  Rabbit  Target Name:  TDO2  Sample Tissue:  Human Liver Tumor  Antibody Dilution:  1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$522.50
Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged TDO2 is approximately 10 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Hund Kaninchen Unkonjugiert IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$727.83
Details
Human Maus Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB TDO2 Antibody (N-term) (ABIN658265) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the TDO2 antibody detected the TDO2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2. Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TDO2 mouse monoclonal antibody. (ABIN2455754) 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p)   0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$481.56
Details

Am meisten referenzierte anti-Tryptophan 2,3-Dioxygenase Antikörper

  1. Human Polyclonal TDO2 Primary Antibody für ICC, IF - ABIN4358259 : Woodling, Colas, Wang, Minhas, Panchal, Liang, Mhatre, Brown, Ko, Zagol-Ikapitte, van der Hart, Khroyan, Chuluun, Priyam, Milne, Rassoulpour, Boutaud, Manning-Boğ, Heller, Andreasson: Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. in Brain : a journal of neurology 2016 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal TDO2 Primary Antibody für WB - ABIN948536 : Xiao, Li, Jones-Brando, Yolken: Abnormalities of neurotransmitter and neuropeptide systems in human neuroepithelioma cells infected by three Toxoplasma strains. in Journal of neural transmission (Vienna, Austria : 1996) 2013 (PubMed)

  3. Human Polyclonal TDO2 Primary Antibody für WB - ABIN520811 : Ohira, Hagihara, Toyama, Takao, Kanai, Funakoshi, Nakamura, Miyakawa: Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus. in Molecular brain 2010 (PubMed)

Weitere Antikörper gegen Tryptophan 2,3-Dioxygenase Interaktionspartner

Human Tryptophan 2,3-Dioxygenase (TDO2) Interaktionspartner

  1. Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation.

  2. the potent antimicrobial as well as immunoregulatory effects of TDO (zeige DLX3 Antikörper) were substantially impaired under hypoxic conditions that pathophysiologically occur in vivo. This might be detrimental for the appropriate host immune response towards relevant pathogens.

  3. High TDO2 expression is associated with Colorectal Cancer.

  4. Crystal tryptophan 2,3-dioxygenase structure revealed eight residues playing critical roles in L-tryptophan oxidation.

  5. IL-1beta (zeige IL1B Antikörper) is suggested to stimulate tryptophan catabolism and production of IL-6 (zeige IL6 Antikörper) and IL-8 (zeige IL8 Antikörper) by increasing TDO (zeige DLX3 Antikörper) expression in endometriosis.

  6. Identification of 12 polymorphisms in the human TDO2 promoter region, 2 of them corresponding to previously unknown single-nucleotide polymorphisms and 3 of them located in putative glucocorticoid-responsive elements.

  7. TDO (zeige DLX3 Antikörper) is highly expressed in the brains of Alzheimer disease patients.

  8. The data suggest that TDO (zeige DLX3 Antikörper) uses a ring-opening mechanism during N-formylkynurenine formation, rather than Criegee or dioxetane mechanisms as previously proposed.

  9. subtle differences between the TDO (zeige DLX3 Antikörper) and IDO (zeige IDO1 Antikörper) reactions

  10. Polymorphism of tryptophan 2,3 dioxygenase gene is associated with autism.

Mouse (Murine) Tryptophan 2,3-Dioxygenase (TDO2) Interaktionspartner

  1. Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation.

  2. Data suggest that Indoleamine 2,3-dioxygenase 1 (IDO1 (zeige IDO1 Antikörper)) appears to be a potential hallmark of liver lesions, and its deficiency protects mice from CCl4 (zeige CCL4 Antikörper)-induced fibrosis mediated by Th17 cells down-regulation and tryptophan 2,3-dioxygenase (TDO) compensatory increase.

  3. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1 (zeige IDO1 Antikörper), indoleamine 2,3-dioxygenase 2 (zeige IDO2 Antikörper) and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.

  4. Data suggest that high-fat diet (HFD) alters regulation of expression of sirtuins (Sirt4 (zeige SIRT4 Antikörper) and Sirt7 (zeige SIRT7 Antikörper)) and enzymes in NAD biosynthetic pathway (Tdo2 and Nnmt (zeige NNMT Antikörper)); these alterations are more prominent in liver as compared to white adipose tissue or skeletal muscle; Tdo2 and Nnmt (zeige NNMT Antikörper) may serve as markers of HFD consumption. (Tdo2 = tryptophan 2,3-dioxygenase; Nnmt (zeige NNMT Antikörper) = nicotinamide N-methyltransferase (zeige NNMT Antikörper))

  5. both TDO and IDO (zeige IDO1 Antikörper) biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice

  6. Data indicate that tryptophan 2,3-dioxygenase (Tdo2) may play an important role during mouse decidualization and be regulated by estrogen, progesterone, and cAMP.

  7. These findings demonstrate a direct molecular link between Trp (zeige TYRP1 Antikörper) metabolism and neurogenesis and anxiety-related behavior under physiological conditions.

  8. Endometrial expression of TDO in epithelial and stromal cells is regulated by HOXA10 (zeige HOXA10 Antikörper). Expression level of TDO influences infiltration of T-cells into endometrial stroma and thus may influence embryo viability.

  9. These findings indicate that TDO might be required at a late-stage of granule cell development, such as during axonal and dendritic growth, synaptogenesis and its maturation.

  10. No relationship was found between alcohol consumption, Tdo2 activity, and single nucleotide substitution in intron 6 of the Tdo2 gene assoiated with predisposition to alcoholism in humans.

Tryptophan 2,3-Dioxygenase (TDO2) Antigen-Profil

Protein Überblick

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Genbezeichner und Symbole assoziert mit TDO2

  • tryptophan 2,3-dioxygenase b (tdo2b) Antikörper
  • tryptophan 2,3-dioxygenase (tdo2) Antikörper
  • tryptophan 2,3-dioxygenase (TDO2) Antikörper
  • tryptophan 2,3-dioxygenase (MADE_02822) Antikörper
  • tryptophan 2,3-dioxygenase (CtCNB1_3657) Antikörper
  • tryptophan 2,3-dioxygenase a (tdo2a) Antikörper
  • tryptophan 2,3-dioxygenase (CNC04830) Antikörper
  • tryptophan 2,3-dioxygenase (tdo) Antikörper
  • tryptophan 2,3-dioxygenase (Mrub_2119) Antikörper
  • tryptophan 2,3-dioxygenase (Deipr_2235) Antikörper
  • tryptophan 2,3-dioxygenase (Acav_1166) Antikörper
  • tryptophan 2,3-dioxygenase (Mesop_4278) Antikörper
  • tryptophan 2,3-dioxygenase (Tdo2) Antikörper
  • tryptophan 2,3-dioxygenase L homeolog (tdo2.L) Antikörper
  • AA407491 Antikörper
  • chky Antikörper
  • DDBDRAFT_0190495 Antikörper
  • DDBDRAFT_0231363 Antikörper
  • DDB_0190495 Antikörper
  • DDB_0231363 Antikörper
  • fb62b10 Antikörper
  • fi30d08 Antikörper
  • Tdo Antikörper
  • tdo2 Antikörper
  • tdo2l Antikörper
  • TO Antikörper
  • TPH2 Antikörper
  • TRPO Antikörper
  • wu:fb62b10 Antikörper
  • wu:fi30d08 Antikörper
  • zgc:63488 Antikörper
  • zgc:103693 Antikörper

Bezeichner auf Proteinebene für TDO2

TDO-B , TO-B , TRPO-B , tryptamin 2,3-dioxygenase B , tryptophan 2,3-dioxygenase B , tryptophan 2,3-dioxygenase, like , tryptophan oxygenase B , tryptophan pyrrolase B , tryptophanase B , TDO , TO , TRPO , tryptamin 2,3-dioxygenase , tryptophan oxygenase , tryptophan pyrrolase , tryptophanase , tryptophan 2,3-dioxygenase , TDO-A , TO-A , TRPO-A , tryptamin 2,3-dioxygenase A , tryptophan 2,3-dioxygenase A , tryptophan oxygenase A , tryptophan pyrrolase A , tryptophanase A , tdo variant1 , tdo variant2 , tryptophan-2,3-dioxygenase , tryptophan-23-dioxygenase

GENE ID SPEZIES
334082 Danio rerio
548450 Xenopus (Silurana) tropicalis
699739 Macaca mulatta
736252 Pan troglodytes
4456236 Ralstonia eutropha H16
4649802 Gramella forsetii KT0803
6776077 Alteromonas macleodii 'Deep ecotype'
8562285 Comamonas testosteroni CNB-2
100008541 Danio rerio
3256592 Cryptococcus neoformans var. neoformans JEC21
8617171 Dictyostelium discoideum AX4
8880228 Meiothermus ruber DSM 1279
10265555 Deinococcus proteolyticus MRP
10306071 Acidovorax avenae subsp. avenae ATCC 19860
10828127 Mesorhizobium opportunistum WSM2075
6999 Homo sapiens
475476 Canis lupus familiaris
56720 Mus musculus
64206 Rattus norvegicus
530397 Bos taurus
100344083 Oryctolagus cuniculus
100727713 Cavia porcellus
100301559 Sus scrofa
422409 Gallus gallus
495495 Xenopus laevis
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