anti-Troponin T2, Cardiac (TNNT2) Antikörper

Human Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. Data suggest that clinical characteristics can be used to identify low risk patients with acute chest pain and Normal high sensitivity cardiac troponin (hs-cTn) levels.

2. Troponin-T mutation is associated with Hypertrophic cardiomyopathy.

3. These data suggest that associations of high-sensitivity cardiac troponin I and high-sensitivity cardiac troponin T with cardiac injury detected by electrocardiography are driven by different mechanisms.

4. Serum cardiac troponin T associated with cardiovascular complications after heart transplantation.

5. Troponin T is neither specific nor useful as cardiac biomarker for post mortem sample

6. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis].

7. Cardiac troponin T is the key diagnostic marker in Non-ST elevated myocardial infarction (NSTEMI).

8. the optimal cutoff-value of hs-TnT to improve diagnostic accuracy of acute myocardial infarction in chronic kidney disease patients, was determined.

9. This study has confirmed the higher reference levels of hscTnT in neonates and young infants when compared with adult population

10. The current results indicate that patients with nondipper hypertension (NDH) had higher high-sensitivity - cTnT levels than the patients with dipper hypertension. High-sensitivity -cTnT was an independent predictor of NDH and was significantly related with nondipping status.

11. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review].

12. Data suggest that high sensitivity cardiac troponin (hs-cTnT) may help predict whether non-acute coronary syndrome (ACS) emergency department (ED) patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses.

13. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling.

14. On admission, high-sensitivity-troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.

15. Serum high-sensitivity cardiac troponin T (HS-cTnT) level is high and associated with carotid plaques in systemic lupus erythematous (SLE) patients.

16. High sensitivity troponin T was detectable in over half of the congenitally corrected transposition of the great arteries population and was related to right ventricular function.

17. In patients with perinatal asphyxia, the difference in troponin-T concentrations between moderate and severe encephalopathy was not statistically significant. Troponin-T concentration was significantly higher in babies with hypotensive shock and hepatic injury, but not acute kidney injury.

18. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies

19. Plasma troponin T was not altered after stress in patients with a positive stress test or those with a negative stress test.

20. IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis

Mouse (Murine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling.

2. Hypertrophic cardiomyopathy pathophysiology is "mutation specific" in mice models carrying TNNT2 E163R and R92Q mutations.

3. TnTA30V mutation attenuated Ca(2+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin heavy chain but augmented these parameters against beta-myosin heavy chain, suggesting divergent contractile phenotypes.

4. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A overexpression.

5. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT, Ca(2+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

6. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain

7. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

8. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

9. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

10. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

11. TnT mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 and hypertrophic cardiomyopathy in the presence of MYH7.

12. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

13. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

14. Mice carrying the Delta160E or E163R mutations exhibit sarcomeric disruption.

15. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T.

16. Study is the first to show that the interplay between the N terminus of cTnT and the overlapping ends of contiguous Tm effectuates different states of Tm on the actin filament.

17. We conclude that the observed clinical severity of the cTnT Delta160E mutation is caused by a combination of direct sarcomeric disruption coupled to a profound dysregulation of Ca(2+) homeostasis

18. Report two distinct functional regions within the N-terminus of cTnT with divergent roles in mediating cardiac contractile activation.

19. Data show that cardiac TnI gene transition and the alternatively spliced cardiac TnT isoform switching occur in postnatal pulmonary vein.

20. findings provide new evidence to demonstrate that R92 mutation effects on cardiac contractile function and dynamics are influenced by myosin heavy chain isoform

Zebrafish Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

3. Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.

2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Rabbit Troponin T2, Cardiac (TNNT2) Interaktionspartner

1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.