anti-Troponin T2, Cardiac (TNNT2) Antikörper

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Zusätzlich bieten wir Ihnen Cardiac Troponin T2 Kits (95) und Cardiac Troponin T2 Proteine (33) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TNNT2 7139 P45379
TNNT2 21956 P50752
TNNT2 24837 P50753
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Top anti-Cardiac Troponin T2 Antikörper auf antikoerper-online.de

Showing 10 out of 382 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TNNT2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Muscle Host:  Mouse  Target Name:  TNNT2  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
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Human Kaninchen Unkonjugiert WB Western blot analysis of cTnT expression in H9 (A), 4T1 (B), human heart (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
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Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
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Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
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Human Kaninchen Unkonjugiert EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Huhn Maus Unkonjugiert IF, IHC, IHC (p) Human Rabbit Heart (formalin-fixed, paraffin-embedded) stained with TNNT2 antibody ABIN462337 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-TNNT2 / CTnT antibody IHC of human rabbit heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Cat Maus Unkonjugiert EIA, IHC (p), IP, WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$495.00
Details
Huhn Maus Unkonjugiert IF, IHC, IHC (p) Anti-TNNT2 / Cardiac Troponin T antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. 250 μL Anmelden zum Anzeigen 11 bis 14 Tage
$757.17
Details
Human Maus Unkonjugiert FACS, ELISA, WB 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
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Cat Maus Unkonjugiert ELISA, IHC, IHC (p) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-TNNT2 / CTnT antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-Cardiac Troponin T2 Antikörper

  1. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody für ICS - ABIN2688864 : Jáchymová, Muravská, Paleček, Kuchynka, Řeháková, Magage, Kr��l, Zima, Horký, Linhart: Genetic variation screening of TNNT2 gene in a cohort of patients with hypertrophic and dilated cardiomyopathy. in Physiological research / Academia Scientiarum Bohemoslovaca 2012 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody für IHC (f), ICS - ABIN2688865 : Lian, Hsiao, Wilson, Zhu, Hazeltine, Azarin, Raval, Zhang, Kamp, Palecek: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 7 Pubmed References

  3. Human Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA - ABIN263477 : Feng, Taggart, Hall, Bryant, Sansone, Kemmerer, Herlich, Lord: Limited additional release of cardiac troponin I and T in isoproterenol-treated beagle dogs with cardiac injury. in Clinical chemistry 2005 (PubMed)
    Show all 6 Pubmed References

  4. Human Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA - ABIN263478 : Goette, Arndt, Röcken, Staack, Bechtloff, Reinhold, Huth, Ansorge, Klein, Lendeckel: Calpains and cytokines in fibrillating human atria. in American journal of physiology. Heart and circulatory physiology 2002 (PubMed)
    Show all 6 Pubmed References

  5. Human Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA (Capture), ELISA - ABIN263480 : Hammerer-Lercher, Erlacher, Bittner, Korinthenberg, Skladal, Sorichter, Sperl, Puschendorf, Mair: Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy. in Clinical chemistry 2001 (PubMed)
    Show all 6 Pubmed References

  6. Human Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA - ABIN263479 : Nakaura, Morimoto, Yanaga, Nakata, Nishi, Imaizumi, Ohtsuki: Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy. in The American journal of physiology 1999 (PubMed)
    Show all 6 Pubmed References

  7. Cow (Bovine) Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA (Detection), ELISA - ABIN191346 : Urasawa, Wada, Machida, Yuasa, Shimatsu, Wakao, Yuasa, Sano, Nonaka, Nakamura, Takeda: Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. in Circulation 2008 (PubMed)
    Show all 6 Pubmed References

  8. Mammalian Monoclonal Cardiac Troponin T2 Primary Antibody für ELISA (Detection), ELISA - ABIN191349 : van den Berg, Abu-Issa, de Boer, Hutson, de Boer, Soufan, Ruijter, Kirby, van den Hoff, Moorman: A caudal proliferating growth center contributes to both poles of the forming heart tube. in Circulation research 2009 (PubMed)
    Show all 6 Pubmed References

Weitere Antikörper gegen Cardiac Troponin T2 Interaktionspartner

Human Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Data suggest that clinical characteristics can be used to identify low risk patients with acute chest pain and Normal high sensitivity cardiac troponin (hs-cTn) levels.

  2. Troponin-T mutation is associated with Hypertrophic cardiomyopathy.

  3. These data suggest that associations of high-sensitivity cardiac troponin I and high-sensitivity cardiac troponin T with cardiac injury detected by electrocardiography are driven by different mechanisms.

  4. Serum cardiac troponin T associated with cardiovascular complications after heart transplantation.

  5. Troponin T is neither specific nor useful as cardiac biomarker for post mortem sample

  6. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis].

  7. Cardiac troponin T is the key diagnostic marker in Non-ST elevated myocardial infarction (NSTEMI).

  8. the optimal cutoff-value of hs-TnT to improve diagnostic accuracy of acute myocardial infarction in chronic kidney disease patients, was determined.

  9. This study has confirmed the higher reference levels of hscTnT in neonates and young infants when compared with adult population

  10. The current results indicate that patients with nondipper hypertension (NDH) had higher high-sensitivity - cTnT levels than the patients with dipper hypertension. High-sensitivity -cTnT was an independent predictor of NDH and was significantly related with nondipping status.

  11. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review].

  12. Data suggest that high sensitivity cardiac troponin (hs-cTnT) may help predict whether non-acute coronary syndrome (ACS) emergency department (ED) patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses.

  13. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling.

  14. On admission, high-sensitivity-troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.

  15. Serum high-sensitivity cardiac troponin T (HS-cTnT) level is high and associated with carotid plaques in systemic lupus erythematous (SLE) patients.

  16. High sensitivity troponin T was detectable in over half of the congenitally corrected transposition of the great arteries population and was related to right ventricular function.

  17. In patients with perinatal asphyxia, the difference in troponin-T concentrations between moderate and severe encephalopathy was not statistically significant. Troponin-T concentration was significantly higher in babies with hypotensive shock and hepatic injury, but not acute kidney injury.

  18. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies

  19. Plasma troponin T was not altered after stress in patients with a positive stress test or those with a negative stress test.

  20. IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis

Mouse (Murine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling.

  2. Hypertrophic cardiomyopathy pathophysiology is "mutation specific" in mice models carrying TNNT2 E163R and R92Q mutations.

  3. TnTA30V mutation attenuated Ca(2+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin heavy chain but augmented these parameters against beta-myosin heavy chain, suggesting divergent contractile phenotypes.

  4. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A overexpression.

  5. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT, Ca(2+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  6. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain

  7. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  8. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  9. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  10. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  11. TnT mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 and hypertrophic cardiomyopathy in the presence of MYH7.

  12. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

  13. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

  14. Mice carrying the Delta160E or E163R mutations exhibit sarcomeric disruption.

  15. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T.

  16. Study is the first to show that the interplay between the N terminus of cTnT and the overlapping ends of contiguous Tm effectuates different states of Tm on the actin filament.

  17. We conclude that the observed clinical severity of the cTnT Delta160E mutation is caused by a combination of direct sarcomeric disruption coupled to a profound dysregulation of Ca(2+) homeostasis

  18. Report two distinct functional regions within the N-terminus of cTnT with divergent roles in mediating cardiac contractile activation.

  19. Data show that cardiac TnI gene transition and the alternatively spliced cardiac TnT isoform switching occur in postnatal pulmonary vein.

  20. findings provide new evidence to demonstrate that R92 mutation effects on cardiac contractile function and dynamics are influenced by myosin heavy chain isoform

Zebrafish Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Rabbit Troponin T2, Cardiac (TNNT2) Interaktionspartner

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Cardiac Troponin T2 (TNNT2) Antigen-Profil

Protein Überblick

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Genbezeichner und Symbole assoziert mit TNNT2

  • troponin T2, cardiac type (TNNT2) Antikörper
  • troponin T2, cardiac (Tnnt2) Antikörper
  • troponin T2, cardiac type (Tnnt2) Antikörper
  • troponin T type 2a (cardiac) (tnnt2a) Antikörper
  • troponin T2, cardiac type L homeolog (tnnt2.L) Antikörper
  • troponin T2e, cardiac (tnnt2e) Antikörper
  • CMH2 Antikörper
  • CMPD2 Antikörper
  • CT3 Antikörper
  • cTnT Antikörper
  • Ctt Antikörper
  • CTTG Antikörper
  • LVNC6 Antikörper
  • RATCTTG Antikörper
  • RCM3 Antikörper
  • si:ch211-136g2.1 Antikörper
  • tnnt2 Antikörper
  • Tnnt3 Antikörper
  • Tnt Antikörper
  • TnTC Antikörper

Bezeichner auf Proteinebene für TNNT2

cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , troponin T, cardiac muscle , troponin T2, cardiac , cardiac TnT , cardiac muscle troponin T , tnTc , Troponin T cardiac , cTnT , cardiac troponin T2 , sih , silent heart , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , cardiac troponin T , troponin T type 2, cardiac , cardiac troponin 2 , Troponin T, cardiac muscle , troponin T cardiac isoform , novel slow skeletal troponin T family protein , troponin T2e, cardiac

GENE ID SPEZIES
7139 Homo sapiens
21956 Mus musculus
24837 Rattus norvegicus
58071 Danio rerio
286816 Bos taurus
396433 Gallus gallus
403532 Canis lupus familiaris
493940 Felis catus
100379561 Cavia porcellus
398518 Xenopus laevis
100622450 Sus scrofa
100009428 Oryctolagus cuniculus
556703 Danio rerio
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