Tripartite Motif Containing 11 Proteine (TRIM11)

Human Tripartite Motif Containing 11 (TRIM11) Interaktionspartner

1. Data show that miR (zeige MLXIP Proteine)-24-3p downregulation contributes to tripartite motif-containing protein 11 (TRIM11) upregulation in cancer (CC).

2. TRIM11 promotes the development and progression of HCC (zeige FAM126A Proteine) through regulating p53 (zeige TP53 Proteine) and its downstream signals.

3. data showed that tripartite motif-containing protein 11(TRIM11) expression was significantly elevated in hepatocellular carcinoma(HCC (zeige FAM126A Proteine)) tissues and overexpression of TRIM11 is closely associated with HCC (zeige FAM126A Proteine) progression and poor survival

4. Results show that TRIM11 was highly expressed in lung cancer tissues and cell lines and suggest that it acts as an oncogene (zeige RAB1A Proteine) in lung cancer through promoting cell growth, migration and invasion.

5. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.

6. TRIM11 to be overexpressed in HCC (zeige FAM126A Proteine) tissues and cell lines. Downregulation of TRIM11 inhibited HCC (zeige FAM126A Proteine) cell proliferation and invasion in vitro and in vivo as well as suppressed the epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) process.

7. study identified TRIM11 as a new HIV-1 capsid binding protein; data also reveal that TRIM11 restricts HIV-1 reverse transcription by accelerating viral uncoating, and microtubule dynamics is implicated in TRIM11-imposed block to early events of HIV-1 replication

8. TRIM11 is a host cellular factor that interferes with the early steps of HIV-1 replication and provides a connection between viral protein and host antiviral factors.

9. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth.

10. TRIM11 negatively regulates IFN-beta (zeige IFNB1 Proteine) production and antiviral activity by targeting TBK1 (zeige TBK1 Proteine).

Mouse (Murine) Tripartite Motif Containing 11 (TRIM11) Interaktionspartner

1. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.

2. The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways.