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TREM1 encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. Zusätzlich bieten wir Ihnen TREM1 Antikörper (281) und TREM1 Kits (71) und viele weitere Produktgruppen zu diesem Protein an.
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Human TREM1 Protein expressed in Wheat germ - ABIN1323572
Li, Birkenheuer, Marr, Levy, Yoder, Nordone: Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils. in Developmental and comparative immunology 2011
Show all 2 Pubmed References
TREM-1 overexpression and M1 macrophage polarization are associated with obesity-induced insulin (zeige INS Proteine) resistance.
TREM-1 may have a role in pathology of craniopharyngioma and Rathke's cleft cyst
low expression level of TREM-1 might be a characteristic for tumor-associated macrophages in lung cancer
The results demonstrate that both commensal and pathogenic oral bacteria activate the TREM-1 pathway, resulting in a proinflammatory TREM-1 activity-dependent increase in proinflammatory cytokine production.
Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus.
In the premature rupture of membranes group,the NF-kappaB (zeige NFKB1 Proteine) p65 (zeige GORASP1 Proteine) and sTREM-1 levels in maternal blood were significantly higher in women with chorioamnionitis than women without chorioamnionitis (P<.05).
Diagnostic value of sTREM-1, IL-8 (zeige IL8 Proteine), PCT (zeige UROD Proteine), and CRP (zeige CRP Proteine) in febrile neutropenia after autologous stem cell transplantation
findings showed detectable expression of TREM-1 in 100% of samples, urinary tract infection (UTI (zeige AMBP Proteine)) and non-UTI (zeige AMBP Proteine) groups; levels of sTREM-1 were detected in patients with UTI (zeige AMBP Proteine), but not in non-UTI (zeige AMBP Proteine) patients; TREM-1 levels in patients with UTI (zeige AMBP Proteine) tend to be higher and are associated with increased neutrophils and cytokine activity induced by bacteria
This study provided evidence that rs6910730G, an intronic variant of TREM1, reduced the ability of human monocytes for Abeta (zeige APP Proteine) phagocytosis, and this reduction was likely attributed to a decreased monocytic TREM1 expression.
Studies show that bronchoalveolar lavage fluid (BALF) soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels do not discriminate between mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD (zeige ARCN1 Proteine)), in contrast, the interleukin 6 (IL-6 (zeige IL6 Proteine))/interleukine 13 (IL-13 (zeige IL13 Proteine)) ratio measured in BALF effectively differentiated these two diseases.
Experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE associated with increased TREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 (zeige TYROBP Proteine) in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury.
these data suggested that TREM-1 signaling pathway may be a therapeutic target to prevent the effects of the inflammatory dendritic cells in systemic lupus erythematosus and miRNA-150 serves as the important regulator
The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion
This study is the first to show the regulatory role of TREM-1 in RLRs and TLRs expression.
TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis
TGF-beta1 (zeige TGFB1 Proteine) increased the expression of TREM-1 in mouse macrophages partly via the transcription factor AP-1 (zeige JUN Proteine).
in macrophages, oxidized low-density lipoprotein enhanced expression of TREM-1, which amplifies the innate immune response of Toll (zeige TLR4 Proteine)-like receptor pathway; activation of TREM-1 contributes to atherogenesis process by enhancing proinflammatory cytokine production and foam cell formation.
TREM-1 and Dectin-1 (zeige CLEC7A Proteine) function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.
Molecular cloning of bovine TREM-1 extends the repertoire of bovine pattern recognition receptors and provides information important for investigating their role in bovine innate immunity.
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
triggering receptor expressed on myeloid cells 1
, triggering receptor expressed on monocytes 1
, triggering-receptor TREM1
, triggering receptor expressed in monocytes 1
, triggering receptor expressed on myeloid cells-1