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Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003 [PubMed 12853460]).[supplied by OMIM, Dec 2009].. Zusätzlich bieten wir Ihnen Trichohyalin Kits (7) und und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Monoclonal Trichohyalin Primary Antibody für IHC (fro), IHC (p) - ABIN1042685
Takahashi, Horiuchi, Yoshida, Isogai, Kawada, Tezuka: Properties and histochemical application of a novel antibody against trichohyalin granules. in Archives of dermatological research 2007
Show all 4 Pubmed References
The difference between the twoinduced pluripotent stem cell(IPSC) clones in TCHH methylation did not have an obvious effect on its expression in 3D human epidermal equivalent, suggesting that differentiation and tissue formation may mitigate variations in the iPSC methylome.
The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.
To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575).
Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder.
In human keratinocytes, we found BMP-4 facilitates trichohyalin (THH) transcription, and lamin C plays a key role in the posttranslational stabilization of THH.
Common variants in the TCHH gene are associated with straight hair in Europeans.
In anagenic hair follicles AHF latches onto the keratin bundles by its C-terminus and rearranges the keratin meshwork by intrinsic cohesive activity for the granule formation.
Trichohyalin is a multi-functional cross-bridging protein that functions in the inner root sheath and other specialized epithelial tissues
BMP-4 signalling activates AHF/THH transcription in hair follicles.
Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003
, hair follicle protein AHF