Transmembrane Protease, serine 4 Proteine (TMPRSS4)

TMPRSS4 encodes a member of the serine protease family. Zusätzlich bieten wir Ihnen TMPRSS4 Antikörper (92) und TMPRSS4 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TMPRSS4 56649 Q9NRS4
TMPRSS4 214523 Q8VCA5
Ratte TMPRSS4 TMPRSS4 367074  
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Showing 4 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
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TMPRSS4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,

Weitere Proteine zu Transmembrane Protease, serine 4 (TMPRSS4) Interaktionspartnern

Zebrafish Transmembrane Protease, serine 4 (TMPRSS4) Interaktionspartner

  1. in vivo TMPRSS4a gene silencing caused severe defects in tissue development and cell differentiation including a disturbed skeletal muscle formation, a decelerated heartbeat, and a degenerated vascular system

Human Transmembrane Protease, serine 4 (TMPRSS4) Interaktionspartner

  1. Data suggest that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by long noncoding RNAs (lncRNAs) SMARCC2/miR-551b-3p/transmembrane protease, serine 4 protein (TMPRSS4) axis.

  2. The miR125a5p/TMPRSS4/NFkappaB axis may thus provide novel insight into the pathogenic mechanisms of lung adenocarcinoma and may be used in the development of novel treatment strategies for lung adenocarcinoma .

  3. we demonstrated a mechanistic cascade of TMPRSS4 up-regulating STAT3 activation and subsequent TWIST1 expression, leading to prostate cancer migration.

  4. TMPRSS4 is overexpressed in Idiopathic pulmonary fibrosis lungs.

  5. TMPRSS4 protein expression in esophageal carcinoma was correlated with patient demographic characteristics, tumor type, high TNM stages and overall survival.

  6. TMPRSS4 modulates both invasion and proliferation via Slug and cyclin D1, which is a previously unrecognized pathway that may regulate metastasis and cancer progression

  7. We conclude that TMPRSS4 overexpression in solid tumors is associated with patients' poor prognosis. TMPRSS4 could be a valuable prognosis biomarker or a promising therapeutic target of solid tumor.

  8. High TMPRSS4 expression is associated with pancreatic adenocarcinoma.

  9. TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in lung squamous cell carcinomas

  10. These results revealed that CLDN1 contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies.

  11. TMPRSS4 overexpression promoted the proliferation, invasion and migration of breast cancer cells by possibly inducing epithelial-mesenchymal transition

  12. The increase of TMPRSS4 expression may be a key event for HCC progression and may be regarded as a potential prognostic marker for HCC.

  13. suggesting that TMPRSS4 is associated with a cancer stem cells phenotype in patients' tumors

  14. TMPRSS4 expression is associated with postoperative recurrence. In addition, the current survival curves demonstrated that TMPRSS4 expression is associated with statistically significant differences in survival among patients with lung adenocarcinoma.

  15. In prostate cancer, high TMPRSS4 expression was significantly associated with advanced tumor stage and lymphatic metastasis.

  16. TMPRSS4 is overexpressed in thyroid cancer and TMPRSS4-CREB signaling is needed to sustain thyroid cancer cell proliferation.

  17. TMPRSS4 is upregulated by silencing of TFPI-2 through aberrant DNA methylation and contributes to oncogenesis in non-small cell lung cancer.

  18. On the basis of this information and the structural characteristics of this druggable protease, we suggest that TMPRSS4 could be a novel potential therapeutic target in solid tumours.

  19. TMPRSS4 was associated with CRC stage and regulated the proliferation and self-renewal ability of colon cancer cells; TMRPSS4 was involved in the development and progression of CRC.

  20. TMPRSS4 was an independent predictor of OS and DFS.

Mouse (Murine) Transmembrane Protease, serine 4 (TMPRSS4) Interaktionspartner

  1. The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice.

  2. Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4

  3. Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.

  4. TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.

  5. mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation

TMPRSS4 Protein Überblick

Protein Überblick

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TMPRSS4

  • transmembrane protease, serine 4 (TMPRSS4)
  • transmembrane protease, serine 4a (tmprss4a)
  • transmembrane protease, serine 4 (Tmprss4)
  • CAPH2 Protein
  • mCAP2 Protein
  • MT-SP2 Protein
  • TMPRSS3 Protein
  • tmprss4 Protein
  • zgc:152909 Protein

Bezeichner auf Proteinebene für TMPRSS4

transmembrane protease, serine 4 , channel-activating protease 2 , membrane-type serine protease 2 , transmembrane protease serine 4 , transmembrane serine protease 3 , type II membrane serine protease

GENE ID SPEZIES
100071190 Equus caballus
777630 Danio rerio
56649 Homo sapiens
214523 Mus musculus
489387 Canis lupus familiaris
367074 Rattus norvegicus
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