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TMPRSS4 encodes a member of the serine protease family. Zusätzlich bieten wir Ihnen TMPRSS4 Antikörper (91) und TMPRSS4 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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in vivo TMPRSS4a gene silencing caused severe defects in tissue development and cell differentiation including a disturbed skeletal muscle formation, a decelerated heartbeat, and a degenerated vascular system
The miR125a5p/TMPRSS4/NFkappaB axis may thus provide novel insight into the pathogenic mechanisms of lung adenocarcinoma and may be used in the development of novel treatment strategies for lung adenocarcinoma .
we demonstrated a mechanistic cascade of TMPRSS4 up-regulating STAT3 (zeige STAT3 Proteine) activation and subsequent TWIST1 (zeige TWIST1 Proteine) expression, leading to prostate cancer migration.
TMPRSS4 is overexpressed in Idiopathic pulmonary fibrosis lungs.
TMPRSS4 protein expression in esophageal carcinoma was correlated with patient demographic characteristics, tumor type, high TNM (zeige ODZ1 Proteine) stages and overall survival.
TMPRSS4 modulates both invasion and proliferation via Slug and cyclin D1 (zeige CCND1 Proteine), which is a previously unrecognized pathway that may regulate metastasis and cancer progression
We conclude that TMPRSS4 overexpression in solid tumors is associated with patients' poor prognosis. TMPRSS4 could be a valuable prognosis biomarker or a promising therapeutic target of solid tumor.
High TMPRSS4 expression is associated with pancreatic adenocarcinoma.
TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in lung squamous cell carcinomas
These results revealed that CLDN1 contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies.
TMPRSS4 overexpression promoted the proliferation, invasion and migration of breast cancer cells by possibly inducing epithelial-mesenchymal transition
The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice.
Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease (zeige F2 Proteine) CAP2/Tmprss4
Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
TMPRSS4 primarily activates ENaC (zeige SCNN1A Proteine) by cleaving basic residues within the tract gammaK173-K186 distal to the furin (zeige FURIN Proteine) cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC (zeige SCNN1A Proteine) activation
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.
transmembrane protease, serine 4
, channel-activating protease 2
, membrane-type serine protease 2
, transmembrane protease serine 4
, transmembrane serine protease 3
, type II membrane serine protease