Transmembrane Protease, serine 2 Proteine (TMPRSS2)

TMPRSS2 encodes a protein that belongs to the serine protease family. Zusätzlich bieten wir Ihnen TMPRSS2 Antikörper (76) und TMPRSS2 Kits (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TMPRSS2 7113 O15393
Ratte TMPRSS2 TMPRSS2 156435  
TMPRSS2 50528 Q9JIQ8
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Showing 7 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$656.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Maus T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$714.00
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
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TMPRSS2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine) ,
, ,

Weitere Proteine zu Transmembrane Protease, serine 2 (TMPRSS2) Interaktionspartnern

Human Transmembrane Protease, serine 2 (TMPRSS2) Interaktionspartner

  1. RNA of AZI1 functions as the "initiator" RNA to induce TMPRSS2-ERG fusion.

  2. Binding of fusion oncogene protein TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis.

  3. ERG expressed by the TMPRSS2:ERG fusion could also transactivate the ERRalpha (ESRRA) gene.

  4. Our findings indicate that TGF-beta signaling is a major determinant of EMT in T/E overexpressing LNCaP cells.

  5. A potential novel function of TMPRSS2-ERG as a major regulator of IGF1R gene expression.

  6. Study shows that T2E fusion transcripts are associated with higher levels of AMACR mRNA in patients with atypical small acinar proliferation (ASAP) which represents an indicator of risk for prostate cancer in patients with ASAP.

  7. TMPRSS2-ERG may have a role in progression of prostate neoplasms and in alteration of the metabolic profile

  8. We propose that epigenetic events are a significant and alternative driver of aggressive disease in TMPRSS2-ERG fusion-negative prostate cancer.

  9. Meta-analysis showed the prevalence of TMPRSS2:ERG fusions in prostate cancer to be highest in men of European descent (49%), followed by Asians (27%) and then African (25%) descent.

  10. Data show that tumors displaying TMPRSS2-ERG fusions that retained interstitial genes were less likely to be associated with biochemical recurrence

  11. We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2-ERG gene fusions. The transcriptional status and epigenetic features of the target genes influence this effect.

  12. NOTCH pathway inhibition antagonizes the growth and invasion of transmembrane protease serine 2 (TMPRSS2)-transforming protein ERG (ERG) (T2E) -positive prostate cancer cells.

  13. The TMPRSS2-ERG gene fusion is the most frequently observed genetic aberration in prostate cancer.

  14. Study provide evidence that PTEN deletion and TMPRSS2-ERG gene fusion were mutually exclusive in patients with prostate neoplasm. TMPRSS2-ERG gene fusion was rare compared to peripheral zone tumors and to PTEN inactivation in T1a transition zone tumors.

  15. miR-204 upregulates androgen receptor (AR ) and downregulates TMPRSS2/ERG through direct regulation of their promoter methylation and set of transcription factors during AR cancer-related reprogramming.

  16. differential expression of TMPRSS2:ERG in urine exosomes in prostate cancer and controls

  17. The present study established evidence for the first two common PrCa risk variants differentially associated with TMPRSS2:ERG fusion status. TMPRSS2:ERG phenotyping of larger studies is required to determine comprehensive sets of variants with subtype-specific roles in prostate cancer.

  18. Human coronavirus 229E presumably evolved to bypass the endosome by entering the cell via TMPRSS2.

  19. Studies indicate that TMPRSS2-ERG fusion gene positive prostate cancers cells rewire intracellular signaling cascades and modulate gene and protein network.

  20. TMPRSS2-ERG role in prostate cancer invasiveness and regulation of MMP-9 and plexin B1.

Mouse (Murine) Transmembrane Protease, serine 2 (TMPRSS2) Interaktionspartner

  1. Study shows that Influenza A (IAV) possessing a monobasic cleavage site in the haemagglutinin (HA) replicates poorly in TMPRSS2 knockout mice due to insufficient HA cleavage. On the contrary, IBV successfully underwent HA cleavage in TMPRSS2 knockout mice, and that the mouse-adapted strain was fully pathogenic. These data demonstrate a clear difference between IAV and IBV in their molecular mechanisms for spreading.

  2. DPP4:CD9:TTSP as the protein complexes are necessary for early efficient MERS-coronavirus entry.

  3. Genetic inhibition of TMPRSS2-ERG junction oncogene in prostate cancer by means of siRNA has strong antineoplastic effect in a mouse model and in vitro.

  4. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis

  5. TMPRSS2 as a host cell factor essential for viral spread and pathogenesis of mono-basic H1N1 and H3N2 influenza A viruses.

  6. These results demonstrate that TMPRSS2 expression is essential for influenza A virus replication in vivo.

  7. These data demonstrate that TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 and H1N1 influenza virus in mice.

  8. Loss of TMPRSS2 serine protease activity does not influence fertility, reduce survival, result in prostate hyperplasia or carcinoma, or alter prostatic luminal epithelial cell regrowth following castration and androgen replacement.

TMPRSS2 Protein Überblick

Protein Überblick

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TMPRSS2

  • transmembrane protease serine 2-like (LOC100739411)
  • transmembrane protease, serine 2 (TMPRSS2)
  • transmembrane protease, serine 2 (Tmprss2)
  • D16Ertd61e Protein
  • PP9284 Protein
  • PRSS10 Protein

Bezeichner auf Proteinebene für TMPRSS2

epitheliasin , serine protease 10 , transmembrane protease serine 2 , plasmic transmembrane protein X

GENE ID SPEZIES
100739411 Sus scrofa
7113 Homo sapiens
156435 Rattus norvegicus
50528 Mus musculus
418528 Gallus gallus
100732077 Cavia porcellus
100337870 Oryctolagus cuniculus
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