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TMED10 is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain.
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Human Polyclonal TMED10 Primary Antibody für IHC, ELISA - ABIN1003292
Blum, Feick, Puype, Vandekerckhove, Klengel, Nastainczyk, Schulz: Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. in The Journal of biological chemistry 1996
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Human Polyclonal TMED10 Primary Antibody für IHC, ELISA - ABIN1003291
Periz, Fortini: Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. in Journal of neuroscience research 2004
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Low TMED10 expression is associated with breast cancer.
Surface plasmon resonance and solution NMR analyses revealed that p24beta1 (zeige TMED2 Antikörper) and p24delta1 GOLD domains interact weakly (Kd= ~10(-4)M).
TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy, which may be associated with activation of AMPK (zeige PRKAA1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway.
Study demonstrates that NleF binds to the human Tmp21 protein and subsequently disrupts intracellular protein (zeige CKAP2 Antikörper) trafficking.
Data show that the level of p23 expression is critical for neuronal function, and p23 overexpression initiates a cascade in brainstem that leads to severe motor deficits and other neurological problems, culminating in premature death.
Results suggest that Tmp21 is a novel protein that preferentially binds to Beta(2)-microglobulin-free MHC-I heavy chains.
p23 acts as an anchoring protein that retains PKCdelta (zeige PKCd Antikörper) at the perinuclear region, thus limiting the availability of this kinase for activation in response to stimuli.
Transmembrane protein 23 (zeige SGMS1 Antikörper) and p24A (zeige TMED2 Antikörper) differentially control G-protein coupled receptor (zeige ADRA1A Antikörper) trafficking and signaling in astrocytes.
These results demonstrate that p23/Tmp21 acts as an anchor that distinctively modulates compartmentalization of C1 domain-containing proteins, and it plays an essential role in beta2-chimaerin relocalization.
TMP21, a member of the p24 (zeige TMED2 Antikörper) cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity
These findings suggest that a fraction of p23 (zeige CDK5R1 Antikörper) enters post-Golgi compartments and may function in the biogenesis and/or quality control of SGs (zeige SKI Antikörper).
High levels of p23 (zeige CDK5R1 Antikörper) expression are found in embryonic mouse brain, but the steady-state p23 (zeige CDK5R1 Antikörper) levels gradually decline after birth to the lower adult level.
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
transmembrane protein tmp21
, 21 kDa transmembrane trafficking protein
, 21 kDa transmembrane-trafficking protein
, p24 family protein delta-1
, transmembrane emp24 domain-containing protein 10
, transmembrane protein Tmp21
, transmembrane trafficking protein
, integral membrane protein Tmp21-I (p23)
, transmembrane trafficking protein 21
, p24 delta 1
, integral membrane protein p23