Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) Proteine (TOMM40)

TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008].. Zusätzlich bieten wir Ihnen TOMM40 Antikörper (46) und TOMM40 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TOMM40 10452 O96008
TOMM40 53333 Q9QYA2
Ratte TOMM40 TOMM40 308416 Q75Q40
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,907.67
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,907.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,986.50
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
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TOMM40 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) Interaktionspartnern

Human Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) Interaktionspartner

  1. TOM40 over-expression blocked Ab-elicited decreases in the mitochondrial membrane potential, cellular ATP levels, and cellular viability in the control cells. These data suggest elevated expression of TOM40 may be protective of mitochondrial function.

  2. PPARgamma knockdown resulted in increased levels of TOMM40, APOE and APOC1 -mRNAs, showing the strongest impact on APOE transcript levels.

  3. Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE-APOC2 gene region correlate with AD-related biomarkers and TOMM40 or APOE gene expression in AD.

  4. This study demonstrated that the association of TOMM40 '523-L with cognitive decline is primarily mediated by common neuropathologies. By contrast, the association of TOMM40 '523-S/S is relatively independent of these pathologies.

  5. This study found in middle-aged and aged cohorts that FH altered TOMM40 '523 poly-T genotype associations on memory, and additionally in aged participants for both global decline and cognitive impairment risk.

  6. Our data provide support for TOMM40 variant repeat length as an important contributor to AD-like Medial Temporal Lobe pathology in the absence of APOE epsilon4.

  7. Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied.

  8. report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia.

  9. Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1], and rs429358 [APOE]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise

  10. Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L

  11. meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations

  12. Results reveal an association of APOE epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.

  13. These findings indicated that variants in TOMM40/APOE/APOC1 region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.

  14. Our results do not support the notion that TOMM40 poly-T repeat variants have independent effects on Parkinson's disease with dementia and Dementia with Lewy bodies pathology

  15. rs2075650 polymorphism in TOMM40 gene may increase the risk of Alzheimer disease.

  16. investigate the influence of the TOMM40 intron 6 poly-T variant (rs10524523) on TOMM40 gene expression and cognitive abilities and decline in a cohort of 1613 community-dwelling elderly volunteers

  17. rs2075650 at intron region TOMM40 is associated with the A beta-42 levels in CSF.

  18. No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants

  19. Epilepsy, impaired fine motor function and gastrostomy tube feeding were less common in cerebral palsy children with single nucleotide polymorphisms in the APOE or TOMM40 genes

  20. Its variants are related to impairment in allocentric spatial navigation and reduced cortical thickness of specific brain regions among aMCI individuals with (LOAD neutral) APOE epsilon3/epsilon3 genotype.

Mouse (Murine) Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) Interaktionspartner

  1. the interaction of alpha-Syn with the mitochondrial protein import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.

  2. imported into the outer mitochondrial membrane

Cow (Bovine) Translocase of Outer Mitochondrial Membrane 40 Homolog (Yeast) (TOMM40) Interaktionspartner

  1. Data demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.

TOMM40 Protein Überblick

Protein Überblick

TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005

Genbezeichner und Symbole assoziert mit TOMM40

  • translocase of outer mitochondrial membrane 40 homolog (yeast) (tomm40)
  • translocase of outer mitochondrial membrane 40 homolog L homeolog (tomm40.L)
  • translocase of outer mitochondrial membrane 40 (TOMM40)
  • translocase of outer mitochondrial membrane 40 homolog (yeast) (Tomm40)
  • translocase of outer mitochondrial membrane 40 (Tomm40)
  • AW539759 Protein
  • C19orf1 Protein
  • D19S1177E Protein
  • Mom35 Protein
  • OM38 Protein
  • PER-EC1 Protein
  • PEREC1 Protein
  • Tom40 Protein
  • Tom40A Protein
  • tomm40-a Protein
  • wu:fb68h07 Protein
  • zgc:64168 Protein

Bezeichner auf Proteinebene für TOMM40

translocase of outer mitochondrial membrane 40 , mitochondrial import receptor subunit TOM40 homolog , translocase of outer membrane 40 kDa subunit homolog , translocase of outer mitochondrial membrane 40 homolog a , mitochondrial outer membrane protein , p38.5 , protein Haymaker , haymaker protein , mitochondrial outer membrane protein 35 , mitochondrial outer membrane protein of 35 kDa , mitochondrial outer membrane protein of 38 kDa , outer membrane protein 38 kDa , translocase of outer mitochondrial membrane 40A

GENE ID SPEZIES
322645 Danio rerio
380301 Xenopus laevis
10452 Homo sapiens
53333 Mus musculus
308416 Rattus norvegicus
611055 Canis lupus familiaris
510219 Bos taurus
100731084 Cavia porcellus
101111570 Ovis aries
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