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TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM, May 2008].. Zusätzlich bieten wir Ihnen TOMM40 Antikörper (43) und TOMM40 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE (zeige APOE Proteine)-APOC2 (zeige APOC2 Proteine) gene region correlate with AD-related biomarkers and TOMM40 or APOE (zeige APOE Proteine) gene expression in AD.
This study demonstrated that the association of TOMM40 '523-L with cognitive decline is primarily mediated by common neuropathologies. By contrast, the association of TOMM40 '523-S/S is relatively independent of these pathologies.
This study found in middle-aged and aged cohorts that FH altered TOMM40 '523 poly-T genotype associations on memory, and additionally in aged participants for both global decline and cognitive impairment risk.
Our data provide support for TOMM40 variant repeat length as an important contributor to AD-like Medial Temporal Lobe pathology in the absence of APOE (zeige APOE Proteine) epsilon4.
Survival analyses suggest that AD patients with TOMM40 allele rs2075650-G have an average age of disease onset of 6 years earlier compared with carriers of the A allele. The age of disease onset is earlier if APOE4/4 is present in the Colombian population studied.
report association of APOE (zeige APOE Proteine) and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 (zeige GRLF1 Proteine) and SERPINA1 (zeige SERPINA1 Proteine) with progressive non-fluent aphasia.
Among white women, three single nucleotide polymorphisms (SNPs) (rs2075650 [TOMM40], rs4420638 [APOC1 (zeige APOC1 Proteine)], and rs429358 [APOE (zeige APOE Proteine)]) were significantly associated with survival to 90 years after correction for multiple testing (p < .001); rs4420638 and rs429358 were also significantly associated with healthy aging (p = .02). In African American women, no SNP was associated with longevity. In Hispanic women, 7 SNPs in linkage dise
Each epsilon4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L
meta-analysis to investigate the association between rs2075650 polymorphism and Alzheimer's disease (AD) in Asian, Caucasian, and mixed populations; analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations
Results reveal an association of APOE (zeige APOE Proteine) epsilon3/3-TOMM40'523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.
the interaction of alpha-Syn with the mitochondrial protein (zeige COX6B2 Proteine) import machinery, in particular Tom40, might be an upstream event in alpha-Syn-induced neurotoxicity.
Data demonstrate that LktA interacts with the Tom22 (zeige TOMM22 Proteine) and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins.
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for protein import into mitochondria (Humphries et al., 2005
translocase of outer mitochondrial membrane 40
, mitochondrial import receptor subunit TOM40 homolog
, translocase of outer membrane 40 kDa subunit homolog
, translocase of outer mitochondrial membrane 40 homolog a
, mitochondrial outer membrane protein
, protein Haymaker
, haymaker protein
, mitochondrial outer membrane protein 35
, mitochondrial outer membrane protein of 35 kDa
, mitochondrial outer membrane protein of 38 kDa
, outer membrane protein 38 kDa
, translocase of outer mitochondrial membrane 40A