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Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. Zusätzlich bieten wir Ihnen TFAP2E Antikörper (14) und und viele weitere Produktgruppen zu diesem Protein an.
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These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit.
Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma.
Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer.
AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer
AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development.
TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer.
Report of the expression and function of Tfap2e in developing Xenopus laevis; propose that Tfap2e is a novel player in the gene regulatory network controlling neural crest specification in Xenopus downstream of Pax3 and Zic1
work suggests that AP-2epsilon, which is expressed in late phases of differentiation, is not needed to initiate the apical-basal differentiation dichotomy but for maintaining the basal VSNs' identity. In AP-2epsilon mutants we observed a large number of cells that entered the basal program can express apical genes, our data suggest that differentiated VSNs of mice retain a notable level of plasticity.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
cloning and characterization; AP-2 epsilon is expressed most prominently in the mitral cell layer of the developing olfactory bulb; it is able to activate transcription in a binding site-dependent manner
AP-2 epsilon is important for the development of the olfactory system.
Data demonstrate that transcription factor AP-2epsilon is required for olfactory bulb development, specifically the establishment of appropriate neuronal lamination.
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (By similarity).
, transcription factor AP-2-epsilon
, activating enhancer-binding protein 2-epsilon
, adaptor-related protein complex 2, epsilon subunit
, activating enhancer-binding protein 2 epsilon