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TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.
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our data establish a combinatorial cell-autonomous and non-cell-autonomous role for Top2b in the late stage of photoreceptor differentiation and maturation
We demonstrated that Nup98 (zeige NUP98 Proteine)-TopIIbeta and Nup98 (zeige NUP98 Proteine)-SETBP1 (zeige SETBP1 Proteine) negatively regulate the XPO1 (zeige XPO1 Proteine)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (zeige NUP98 Proteine)-fusion proteins induce tumorigenesis.
TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.
Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.
Top IIbeta might be a down-stream target of Nurr1 (zeige NR4A2 Proteine), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.
Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.
Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 (zeige PARP1 Proteine) and PARP2 (zeige PARP2 Proteine), and this is in turn counteracted by the PAR (zeige AFG3L2 Proteine)-degrading activity of PAR (zeige AFG3L2 Proteine) glycohydrolase.
proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage
DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.
A nuclear matrix-associated (zeige SMARCA5 Proteine) topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2 (zeige CA2 Proteine)+-dependent nuclease (zeige DCLRE1C Proteine) cleaves sperm DNA into loop-sized fragments.
The article discusses origin of topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer. (Review)
recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of anthracycline-induced congestive heart failure .
The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIbeta, while preserving the nuclear localization signal, and mutation of Y656 in topo IIbeta inhibits the decatenation checkpoint and sensitivity to topo II (zeige TOP2 Proteine)-targeted drugs.
TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.
Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (zeige TOP2 Proteine) positivity were strong predictors for preoperative epileptic seizures.
during early development, TOP2A (zeige TOP2A Proteine) is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.
Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I (zeige TOP1 Proteine) and TOPO II (zeige TOP2 Proteine)
A direct interaction between Ku70 (zeige XRCC6 Proteine)/86 and BRG1 (zeige SMARCA4 Proteine) brings together SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.
Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis (zeige CISH Proteine)-acting viral maintenance element.
Proteolytic degradation of Top2 (zeige TOP2A Proteine) enables the processing of Top2 (zeige TOP2A Proteine).DNA and Top2 (zeige TOP2A Proteine).RNA covalent complexes by TDP2 (zeige TDP2 Proteine).
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.
topoisomerase (DNA) II beta 180kDa
, DNA topoisomerase II, beta isozyme
, DNA topoisomerase 2-beta
, topoisomerase II beta
, DNA topoisomerase II beta
, DNA topoisomerase II, 180 kD
, U937 associated antigen
, antigen MLAA-44
, topo II beta
, topoisomerase IIb
, DNA topoisomeraseII_beta
, topoisomerase II beta-2