Topoisomerase (DNA) II beta 180kDa Proteine (TOP2B)

TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Zusätzlich bieten wir Ihnen Topoisomerase (DNA) II beta 180kDa Antikörper (66) und Topoisomerase (DNA) II beta 180kDa Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TOP2B 21974 Q64511
Ratte TOP2B TOP2B 361100  
TOP2B 7155 Q02880
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Top Topoisomerase (DNA) II beta 180kDa Proteine auf antikoerper-online.de

Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$653.82
Details

TOP2B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , ,
,

Weitere Proteine zu Topoisomerase (DNA) II beta 180kDa (TOP2B) Interaktionspartnern

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) Interaktionspartner

  1. our data primarily indicate that topoIIbeta can be used to estimate neuronal differentiation in medulloblastoma

  2. The article discusses origin of topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer. (Review)

  3. recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of anthracycline-induced congestive heart failure .

  4. The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIbeta, while preserving the nuclear localization signal, and mutation of Y656 in topo IIbeta inhibits the decatenation checkpoint and sensitivity to topo II-targeted drugs.

  5. These results explain why hTOPIIa and hTOPIIa are differentially affected by various poisons and demonstrate the utility of C. elegans in understanding the genetics of drug responses.

  6. TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

  7. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II positivity were strong predictors for preoperative epileptic seizures.

  8. during early development, TOP2A is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  9. TopoIIbeta is involved in the cascade of coactivator complexes that are recruited to LTR for regulation of HIV-1 transcription.

  10. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I and TOPO II

  11. A direct interaction between Ku70/86 and BRG1 brings together SWI/SNF remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

  12. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis-acting viral maintenance element.

  13. This study demonstrated that top IIbeta overexpression is necessary for RA-induced neuronal differentiation.

  14. Data suggest that DNA topoisomerase IIbeta (topoIIbeta) silencing can significantly alter the gene expression pattern of genes involved in variety of biological processes and signal transduction pathways.

  15. Proteolytic degradation of Top2 enables the processing of Top2.DNA and Top2.RNA covalent complexes by TDP2.

  16. There is an association between chemosensitivity and Pgp, GST-pi and Topo II expression in gastric cancer.

  17. These results are consistent with the hypothesis that etoposide quinone contributes to etoposide-related leukemogenesis through an interaction with topoisomerase IIbeta.

  18. Downregulating topoisomerase IIbeta confers resistance specifically to mitoxantrone.

  19. Top2beta-DNA cleavage complexes arrest transcription elongation and induce a proteasomal degradation of Top2beta on DNA.

  20. results suggest that the low expression of TOPOIIbeta in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma.

Topoisomerase (DNA) II beta 180kDa (TOP2B) Protein Überblick

Protein Überblick

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.

Genbezeichner und Symbole assoziert mit TOP2B

  • DNA topoisomerase II beta (TOP2B)
  • topoisomerase (DNA) II beta (Top2b)
  • DNA topoisomerase II beta (Top2b)
  • microRNA 4442 (MIR4442)
  • D230016L12Rik Protein
  • Top-2 Protein
  • TOP2B Protein
  • top2beta Protein
  • TOPIIB Protein

Bezeichner auf Proteinebene für TOP2B

topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2

GENE ID SPEZIES
460232 Pan troglodytes
21974 Mus musculus
361100 Rattus norvegicus
7155 Homo sapiens
395966 Gallus gallus
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