Tocopherol (Alpha) Transfer Protein (TTPA) ELISA Kits

TTPA encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. Zusätzlich bieten wir Ihnen TTPA Antikörper (35) und TTPA Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TTPA 7274 P49638
TTPA 25571 P41034
TTPA 50500 Q8BWP5
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Top TTPA ELISA Kits auf

Showing 5 out of 10 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Maus 0.055 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 bis 16 Tage
Human 0.054 ng/mL 0.156-10 ng/mL   96 Tests 6 bis 8 Tage
Human 25.3 pg/mL 62.5 pg/mL - 4000 pg/mL   96 Tests 15 bis 17 Tage
Ratte 0049 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 15 bis 17 Tage
  96 Tests 15 bis 18 Tage

Weitere ELISA Kits für TTPA Interaktionspartner

Human Tocopherol (Alpha) Transfer Protein (TTPA) Interaktionspartner

  1. Low TTP expression is associated with liver fibrosis.

  2. Authors show that a novel interaction between TTP and the CCR4-NOT subunit, CNOT9, is required for recruitment of the deadenylase complex. In addition to CNOT1, CNOT9 is now included in the identified CCR4-NOT subunits shown to interact with TTP.

  3. Data show that, upon binding to its substrate, alpha-TTP acquires tendency to aggregation into thermodynamically stable high molecular weight oligomers with spheroidal particle formed by 24 protein monomers. Oligomerization is triggered by refolding of the N-terminus. These same oligomers are efficiently transported through an endothelial barrier and not through an epithelial one.

  4. alphaTTP does not appear to regulate the uptake and intracellular localization of different vitamin E congeners in cultured liver cells.

  5. These findings provide the basis for a proposed mechanistic model that describes TTP-facilitated trafficking of alpha-tocopherol through hepatocytes.

  6. Current results show that alphaTTP plays a role in endometrial carcinoma. Possibly endometrial cancer cells attempt to protect themselves from increasing oxidative stress by up-regulating alphaTTP.

  7. Single-nucleotide polymorphisms that are commonly found in healthy humans dramatically affect promoter activity of the TTPA gene.

  8. The crystal structure of the alpha-TTP-phosphatidylinositol phosphates (PIPs) complex revealed that the familial vitamin E deficiency-related arginine residues interacted with phosphate groups of the PIPs and that the PIPs binding caused the lid of the alpha-tocopherol-binding pocket to open.

  9. study demonstrated that alpha -TTP can be upregulated in case of oxidative stress in BeWo trophoblast cells; speculate that possibly, alpha -TTP is notonly involved in normal pregnancy, but also in cases of pregnancy disorders with intense oxidative stress

  10. Data show that reduction ("knockdown") of tocopherol transfer protein (TTP) expression resulted in resistance to the vitamin E.

  11. Substitution of residues in helices A8 (F165A and F169A) and A10 (I202A, V206A and M209A) decreased the rate of intermembrane ligand transfer as well as protein adsorption to phospholipid bilayers.

  12. First case of a mutated form of the TTPA gene in a patient also carrying a spinocerebellar ataxia type 8 expansion.

  13. crystal structure reveals two conformations

  14. the positively charged surface of TTPA may serve to orient an interacting protein, which might function to regulate the release of alpha-T through an induced change in conformation of ATTP

  15. Findings suggest the possibility that ataxia with vitamin E deficiency syndrome (AVED) may not arise from an inability of TTP to bind or to transfer alpha tocopherol, but rather from defects in other activities of the protein.

  16. Nuclear localization of TTPA in in trophoblast, fetal capillaries' endothelium and amnion epithelium of human term placentamay represent a novel function of TTPA

  17. In Ataxia with vitamin E deficiency two TTPA mutations were identified: a truncating mutation in a homozygous patient, and a Gly246Arg missense mutation in a compound heterozygous patient associated with a mild and slowly progressive form of the disease.

  18. The physiological role of TTP is anchored in its ability to direct vitamin E trafficking from the endocytic compartment to transport vesicles that deliver the vitamin to the site of secretion at the plasma membrane.

  19. analysis of ligand transfer by the hepatic tocopherol transfer protein

  20. in first-trimester extravillous trophoblast, syncytiotrophoblast and amniotic epithelium

Mouse (Murine) Tocopherol (Alpha) Transfer Protein (TTPA) Interaktionspartner

  1. The presence of alphaTTP and SVCT2 in brain regions implicated in learning, memory and motor control provides an anatomical basis that may explain the higher resistance of this animal model to brain oxidative stress, which is associated with better motor performance and learning abilities in old age.

  2. alpha-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport.

  3. Results suggest that lipid peroxidation due to depletion of alpha-tocopherol impairs Abeta clearances from the brain and from the blood, possibly causing increased Abeta accumulation in Ttpa(-/-)APPsw brain and plasma.

  4. alpha-tocopherol plays a role in the process of implantation

  5. Endogenous TTPA, through the enhancement of MMP 9 expression and proteolytic activation, plays an essential role in the pathogenesis of heparin-produced cerebral hemorrhage.

  6. TTP transports alpha-TCP and oral administration of TTP compensates for TTP in TTP-deficient mice

  7. These data suggest that in vivo network of alpha-tocopherol (AT), AT-metabolites and ATTP affects the transcription of genes driven by AhR, Nrf2 and NF-kappaB, transcription factor networks.

  8. p75(NTR)is up-regulated after tissue injury, blocks fibrinolysis by down-regulating the serine protease, tissue plasminogen activator, and up-regulating PAI-1.

  9. changes in hepatic TTP concentrations were minimal in response to dietary vitamin E levels or environmental tobacco smoke-related oxidative stress

  10. alpha-tocopherol deficiency decreases oxidative stress and unmasks alpha-tocopherol-dependent regulation of mitochondrial function in the brain

  11. Increase expression of tPA implicate fibrinolysis in ALD progression.

  12. The results show that both gender and the hepatic alpha-TTP, but not brain alpha-TTP gene expression are important in determining alpha-T concentrations within the brain.

TTPA Antigen-Profil

Beschreibung des Gens

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.

Genbezeichner und Symbole assoziert mit TTPA

  • alpha tocopherol transfer protein (TTPA) Antikörper
  • tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) (ttpa) Antikörper
  • alpha tocopherol transfer protein (Ttpa) Antikörper
  • tocopherol (alpha) transfer protein (Ttpa) Antikörper
  • alpha-TTP Antikörper
  • alphaTTP Antikörper
  • ATTP Antikörper
  • AVED Antikörper
  • TTP Antikörper
  • TTP1 Antikörper

Bezeichner auf Proteinebene für TTPA

alpha-tocopherol transfer protein , tocopherol (alpha) transfer protein , alpha-TTP , tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) , Alpha-tocopherol transfer protein , Tocopherol transfer protein alpha , alpha TTP

286813 Bos taurus
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771074 Gallus gallus
100196332 Salmo salar
100526668 Ovis aries
7274 Homo sapiens
25571 Rattus norvegicus
50500 Mus musculus
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