Titin-Cap (Telethonin) Proteine (TCAP)

Zebrafish Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability.

Xenopus laevis Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Human Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).

2. Report TCAP mutations in dilated cardiomyopathy.

3. cardiac telethonin is constitutively bis (zeige BAG3 Proteine)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (zeige CA2 Proteine)+) transients.

4. This study identified no pathogenic mutations in BAG3 (zeige BAG3 Proteine), MATR3 (zeige MATR3 Proteine), PTRF (zeige PTRF Proteine) or TCAP in Australian muscular dystrophy.

5. reduced expression of dystrophin (zeige DMD Proteine) and titin (zeige TTN Proteine) is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha (zeige TNF Proteine) may modulate the expression of these proteins via NF-kappaB (zeige NFKB1 Proteine) pathway.

6. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.

7. review of telethonin and other new proteins of the Z-disc of skeletal muscle

8. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle.

9. telethonin may play a role in linking titin (zeige TTN Proteine) filaments at the Z-disk periphery

10. TCAP mutations identified which are associated with hypertrophic cardiomyopathy.

Mouse (Murine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. cardiac telethonin is constitutively bis (zeige BAG3 Proteine)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (zeige CA2 Proteine)+) transients.

2. Tcap is a critical, load-sensitive regulator of t-tubule structure and function.

3. Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.

4. Whereas both promotor E boxes in Tcap are required for full activation by MyoD (zeige MYOD1 Proteine) or myogenin (zeige MYOG Proteine) in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD (zeige MYOD1 Proteine) in NIH3T3 cells.

5. Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.

Pig (Porcine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. TCAP promoter can be activated by MyoD (zeige MYOD1 Proteine), MyoG (zeige MYOG Proteine) and MEF2 (zeige MYEF2 Proteine) in myotubes, which indicated that TCAP may play a role in the regulation of skeletal muscle development.