Titin-Cap (Telethonin) Proteine (TCAP)

Zebrafish Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability.

Xenopus laevis Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Human Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. based on the crystal structure in which Z1Z2 and telethonin1-90 assemble into a 2:1 complex, a single chain fusion protein was designed, comprising two Z1Z2 modules that are connected by flexible linkers N- and C-terminally of the telethonin1-90. Expression of this fusion protein, named ZTZ, affords high yields of soluble expressed and purified protein

2. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).

3. Report TCAP mutations in dilated cardiomyopathy.

4. cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.

5. This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy.

6. reduced expression of dystrophin and titin is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha may modulate the expression of these proteins via NF-kappaB pathway.

7. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.

8. review of telethonin and other new proteins of the Z-disc of skeletal muscle

9. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle.

10. telethonin may play a role in linking titin filaments at the Z-disk periphery

11. TCAP mutations identified which are associated with hypertrophic cardiomyopathy.

12. The titin Z1Z2-telethonin complex resist considerable mechanical force through beta strand crosslinking, suggesting that telethonin is an important component of the N-terminal titin anchor.

13. A dimer of two titin/telethonin complexes is formed within the crystal environment, potentially indicating the formation of higher oligomers.

14. Hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc.

15. telethonin is a sodium channel-interacting protein, and its mutations can alter Na(v)1.5 kinetics and may play a role in intestinal pseudo-obstruction

16. Telethonin might be involved in CVB3-mediated cell damage and in the resulting cardiac dysfunction due to the interaction with Siva.

17. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus.

Mouse (Murine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients.

2. Tcap is a critical, load-sensitive regulator of t-tubule structure and function.

3. Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.

4. Whereas both promotor E boxes in Tcap are required for full activation by MyoD or myogenin in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD in NIH3T3 cells.

5. Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.

Pig (Porcine) Titin-Cap (Telethonin) (TCAP) Interaktionspartner

1. TCAP promoter can be activated by MyoD, MyoG and MEF2 in myotubes, which indicated that TCAP may play a role in the regulation of skeletal muscle development.