Titin (TTN) ELISA Kits

TTN encodes a large abundant protein of striated muscle. Zusätzlich bieten wir Ihnen Titin Antikörper (70) und Titin Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TTN 7273 Q8WZ42
TTN 22138  
Anti-Ratte TTN TTN 84015  
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Top Titin ELISA Kits auf antikoerper-online.de

Showing 9 out of 28 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human 0.113 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 bis 16 Tage
$700.00
Details
Huhn 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
$715.00
Details
Schwein 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
$715.00
Details
Kaninchen 37.5 pg/mL 62.5-4000 pg/mL   96 Tests 12 bis 14 Tage
$715.00
Details
Meerschweinchen 0.469 ng/mL 0.781-50 ng/mL   96 Tests 12 bis 14 Tage
$715.00
Details
Affe 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
$715.00
Details
Rind (Kuh)
  96 Tests 15 bis 18 Tage
$707.14
Details
Schaf 0.469 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests 11 bis 18 Tage
$852.81
Details
Maus
  96 Tests 15 bis 18 Tage
$875.60
Details

Am meisten referenzierte Titin ELISA Kits

  1. Human Titin ELISA Kit für Sandwich ELISA - ABIN414785 : Li, Li, Wang, Yang: Proteomic analysis of effluents from perfused human heart for transplantation: identification of potential biomarkers for ischemic heart damage. in Proteome science 2012 (PubMed)

Weitere ELISA Kits für Titin Interaktionspartner

Human Titin (TTN) Interaktionspartner

  1. PTB4 is a novel titin splicing regulator that counteracts the splice repressor activity of RBM20.

  2. Our case below further highlights the phenotypic variability and cardiac involvement in recessive titinopathy

  3. The study observed abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. Isolated were cardiac myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D and MYH7 E1426K) and measured their contractility and passive stiffness in comparison with donor heart muscle as a control.

  4. Two novel previously undescribed mutations identified in HMERF titinopathy.

  5. Novel mutations in TTN Mex5, Mex6 and A-band exon 340 were identified in homozygosity or compound heterozygosity with a frameshift or nonsense mutation in TTN I- or A-band region. Family members having only one of these TTN mutations were healthy. Our results add yet another entity to the list of distal myopathies: juvenile or early adult onset recessive distal titinopathy.

  6. Missense mutation of TTN may act as a beneficial role in lung squamous cell carcinoma, but not in lung adenocarcinoma.

  7. Study demonstrates that while the basal excitation-contraction-coupling machinery of titin-mutated induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) from dilated cardiomyopathy patients appears intact, their responsiveness to positive inotropic interventions is blunted compared to healthy iPSC-CM.

  8. Titin I27 folds in the mouth of the ribosome exit tunnel.

  9. The finding expands the phenotypes that can be caused by pathogenic variants TTN, which should be considered in lethal congenital contracture syndromes, arthrogryposis multiplex congenita, congenital myopathies, and hydrops fetalis.

  10. A founder effect in TTN was found to be associated with cardiomyopathy.

  11. Obscurin-Binding Domains in Titin

  12. truncating variants important risk factors for atrial fibrillation

  13. Among the 120 dilated cardiomyopathy patients, 20 (16.7%) had TTN truncating variants.

  14. In a case-control study, there was a statistically significant association between an LOF variant in the TTN gene and early-onset AF, with the variant present in a small percentage of participants with early-onset AF (the case group).

  15. novel titin gene-truncating mutation NM_001267550: p.Leu23499fs/c.70497_40498insT found in the proband as well as in her mother in woman with peripartum cardiomyopathy

  16. Titin isoform expression differs in aortic stenosis and aortic regurgitation as adaptive response to different pathophysiologic scenarios.

  17. TTN missense variants were commonly identified in arrhythmogenic cardiomyopathy patients in this cohort, but did not appear to play a primary role in ACM as causative variants.

  18. This is the first study to suggest the involvement of the novel missense CACNA1C c.1786G>A and TTN c.49415G>A variants in the inheritance of symptomatic bradycardia and development of sick sinus syndrome.

  19. We employed WES to detect the mutations of DCM patients and identified 2 novel mutations. Our study expands the spectrum of TTN mutations and offers accurate genetic testing information for DCM patients who are still clinically negative.

  20. urinary concentration of titin correlated significantly with serum creatine kinase concentration, the best-known biomarker of Duchenne muscular dystrophy; the N-terminal fragment of titin in urine has potential as a diagnostic and clinical biomarker for DMD

Mouse (Murine) Titin (TTN) Interaktionspartner

  1. regulation of thick filament length depends on titin and is critical for maintaining muscle health.

  2. It is likely that titin plays a role in the increase of active muscle stiffness during rapid unloading. These results are consistent with the idea that, in addition to the thin filaments, titin is activated upon Ca(2+) influx in skeletal muscle.

  3. Titin-based force enhancement in skeletal muscle is essentially absent in muscular dystrophy with myositis sarcomeres where amino acids in N2A and PEVK titin are deleted, indicating these specific regions along titin are paramount in increasing titin stiffness in an active sarcomere.

  4. Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle.

  5. Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force

  6. Cleavage of C-terminal titin by CAPN3 is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  7. titin affects the tuning of shivering frequency

  8. An increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy.

  9. Pure volume overload induces an increase in titin stiffness that is beneficial and limits eccentric remodeling.

  10. increased titin stiffness promotes myocardial contraction by accelerating the formation of force-generating cross-bridges without decelerating relaxation

  11. Data indicate titin's important roles in diastolic function and disease of the heart.

  12. alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin

  13. Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1.

  14. [review] A mouse model lacking nine titin immunoglobulin domains (IG KO) shows the effects of a small increase in titin stiffness; the mutant mice show changes in muscle contractivity.

  15. In a novel mouse model, titin's stiffness is slightly increased by deleting nine immunoglobulin (Ig)-like domains from titin's constitutively expressed proximal tandem Ig segment (IG KO).

  16. Upregulating compliant titins reduces diastolic chamber stiffness owing to the increased compliance of myocytes, but it depresses end-systolic elastance; under conditions of exercise, the beneficial effects on diastolic function dominate.

  17. Resting and dynamic LV torsional mechanics is impaired in patients with beta-thalassaemia major. Cell and animal models suggest a potential role of titin degradation in iron overload-induced alteration of LV torsional mechanics.

  18. In the diaphragm muscle, exercise increased the expression level of titin (increased titin:MHC ratio) which is expected to increase titin-based stiffness. This effect was absent in the left ventricle.

  19. Increased titin-based passive stiffness is sufficient to cause diastolic dysfunction with exercise intolerance.

  20. Titin plays an important role in determining calcium sensitivity in skinned muscle.

Cow (Bovine) Titin (TTN) Interaktionspartner

  1. titin may be a factor involved in the Frank-Starling mechanism of the heart by promoting actomyosin interaction in response to stretch

  2. calcium affects passive myocardial tension in a titin isoform-dependent manner.

  3. Upon relaxation of shortened myocytes, the restoring stiffness correlates with the titin isoform expression profile with myocytes that express high levels of the stiff isoform (N2B) having the highest restoring stiffness.

Rabbit Titin (TTN) Interaktionspartner

  1. Data show that disulfide isomerization reactions within Ig domains enable a third mechanism of titin elasticity.

  2. A dual-beam optical tweezers measured the mechanics of human alpha-actinin 2 and titin interaction at the single-molecule level. Depending on the direction of force application, the unbinding forces can more than triple. Multiple alpha-actinin/Z-repeat interactions cooperate to ensure long-term stable titin anchoring, while allowing the individual components to exchange dynamically.

  3. The results of this study are consistent with the claim that residual force enhancement is present and is regulated by titin in skeletal psoas myofibrils, but not cardiac papillary myofibrils

  4. landscape recovered all features of our nanomechanics results. The ensemble molten-globule dynamics delivers significant added contractility that may assist sarcomere mechanics, and it may reduce the dissipative energy loss associated with titin unfolding/refolding during muscle contraction/relaxation cycles.

  5. Work done by titin protein folding assists muscle contraction.

  6. Suggest that the increase in the static tension in activated striated muscle is directly associated with Ca(2+)-dependent change in titin properties and not associated with changes in titin-actin interactions.

  7. titin's visco-elastic properties appear to depend on the Ig do- main un/refolding kinetics and that indeed, titin (and thus myofibrils) can become virtually elastic when Ig domain un/refolding is prevented.

  8. Under non-equilibrium conditions across the physiological force range, titin extends by a complex pattern of history-dependent discrete conformational transitions.

  9. We tested the hypothesis that titin properties might be reflected well in single myofibrils. mechanics of titin are well preserved in isolated myofibrils.

  10. Titin might be responsible for passive force enhancement observed in myofibrils.

  11. The structure and self-interactive properties of an approximately 290 kDa ( approximately 100 nm long) tryptic fragment from the I-band part of titin that is extensible in situ, is presented.

  12. results suggest residual force enhancement in skeletal muscle fibers is caused by stiffening of titin upon muscle activation but not with titin binding to actin; finding indicates existence of a Ca(2+)-regulated, titin-based stiffness in skeletal muscle

Pig (Porcine) Titin (TTN) Interaktionspartner

  1. Two polymorphisms previously identified and described in the 3'UTR of MYPN and TTN genes in a group of Italian Large White (ILW) and Italian Duroc (ID) pigs, were analysed.

  2. Titin-actin interaction: PEVK-actin-based viscosity in a large animal.

  3. Neonatal pig hearts showed large N2BA-titin isoforms distinct from those present in the adult porcine myocardium.

  4. findings demonstrate that Tn plays an important role in the Frank-Starling mechanism of the heart via on-off switching of the thin filament state, in concert with titin-based regulation

  5. Report PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

  6. Coexpression of the 2 titin isoforms in large mammals allows longer sarcomere lengths without the development of excessive diastolic tension.

Titin (TTN) Antigen-Profil

Beschreibung des Gens

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Genbezeichner und Symbole assoziert mit Titin (TTN) ELISA Kits

  • titin (TTN) Antikörper
  • titin (Ttn) Antikörper
  • titin (titin) Antikörper
  • titin (TTNLOC100620261) Antikörper
  • 1100001C23Rik Antikörper
  • 2310036G12Rik Antikörper
  • 2310057K23Rik Antikörper
  • 2310074I15Rik Antikörper
  • AF006999 Antikörper
  • AV006427 Antikörper
  • CMD1G Antikörper
  • CMH9 Antikörper
  • CMPD4 Antikörper
  • D330041I19Rik Antikörper
  • D830007G01Rik Antikörper
  • EOMFC Antikörper
  • HMERF Antikörper
  • L56 Antikörper
  • LGMD2J Antikörper
  • mdm Antikörper
  • MYLK5 Antikörper
  • shru Antikörper
  • TMD Antikörper
  • UNC-22 Antikörper

Bezeichner auf Proteinebene für Titin (TTN) ELISA Kits

connectin , rhabdomyosarcoma antigen MU-RMS-40.14 , titin protein homolog , titin

GENE ID SPEZIES
7273 Homo sapiens
22138 Mus musculus
84015 Rattus norvegicus
424126 Gallus gallus
540561 Bos taurus
1791505 Rhodopirellula baltica SH 1
100008570 Oryctolagus cuniculus
100620261 Sus scrofa
100722767 Cavia porcellus
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