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results suggest that TFPI-2 suppresses cancer cell proliferation and invasion partly through the regulation of the ERK1/2 signaling and through interactions with myosin-9 and actinin-4.
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TFPI-2 Protects Against Gram-Negative Bacterial Infection.
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TFPI-2 role in the proliferation and invasion of breast cancer cells.Translocation of TFPI-2 into nucleus affects the promoter activity of the MMP-2 gene.TFPI-2 suppresses breast cancer cell invasion through the regulation of MMP-2 gene expression.
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Mono-ADP-ribosylation of H3R117 upregulated methylation of TFPI2 by impact TET1.
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investigated association between 4 SNPs within TFPI-2 gene and coronary atherosclerosis risk in Chinese Han
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Proliferation, mRNA level of tissue factor pathway inhibitor 2 (TFPI2), and cell invasion were evaluated using anti-Ki-67 antibody staining, reverse transcriptase-polymerase chain reaction and xCELLigence system.
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These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene.
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MiR-616-3p binds specifically to the 3'-UTR region of TFPI2 mRNA.
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Tissue factor pathway Inhibitor 2 potencies differ between antifibrinolytic agents against human and mouse enzymes plasmin, factor XIa, and kallikrein
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estrogen induced TFPI-2 expression in MCF7 cells is mediated by ERalpha and also by the action of LSD1.
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TFPI2 hypermethylation is associated with colorectal cancer.
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our research indicated that miR-130a functions as an oncogene by targeting TFPI2, miR-130a inhibition reduced the growth and angiogenesis of hemangioma by inactivating the FAK/PI3K/Rac1/mdm2 pathway
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TFPI-2 expression was decreased in bladder cancer. TFPI-2 expression was decreased with progression in tumor grade and stage and was correlated to decreased apoptosis.
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TFPI2 is a useful serum biomarker for preoperative clinical diagnosis of CCC.
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This TPR-dependent PP5 inhibition shown by Ro 90-7501 is a unique and novel inhibitory mechanism, which might be a useful tool for studies of PP5 on both regulatory mechanism and drug discovery.
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Over-expression of TFPI-2 and aberrant promoter methylation status presented in the preeclampsia placentas, suggesting that epigenetic mechanism might contribute to the pathogenesis of preeclampsia.
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Its methylation is a prognostic biomarker for hepatocellular carcinoma after hepatectomy.
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Data show that silencing tumor-endothelial cells (EC) for trypsinogen 4 accumulated tissue factor pathway inhibitor-2 (TFPI-2) in the matrix.
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Hypermethylation of TFPI2 promoter is increased in inflamed colon tissue.
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DNA methylation of TFPI2 may play an important role in the carcinogenesis of cervical cancer and that the differential methylation of TFPI2 may at least partially explain the disparity in cervical cancer incidence between Uygur and Han women.