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The protein encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Zusätzlich bieten wir Ihnen Thymopoietin Antikörper (112) und Thymopoietin Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (zeige CASP3 Proteine) and PARP protein levels.
The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (zeige LMNA Proteine), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.
The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (zeige LMNA Proteine), while its interaction with progerin is significantly reduced.
Results highlight the interactions at the nuclear envelope where mutations in the EMD (zeige EMD Proteine) and TMPO gene in combination with mutations in SUN1 (zeige SUN1 Proteine) have an impact on several components of the network.
Data indicate that cells lacking either high mobility group (zeige SSRP1 Proteine) protein N5 (HMGN5 (zeige HMGN5 Proteine)) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.
this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F (zeige E2F1 Proteine) and p53 (zeige TP53 Proteine) activities associate with the positive and negative regulation of LAP2alpha expression, respectively
data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C (zeige LMNA Proteine) complexes
Results indicate that in vitro, the interaction between HA95 (zeige AKAP8L Proteine) and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 (zeige AKAP8L Proteine) rather than by CDK1 (zeige CDK1 Proteine)- or PKC (zeige PRRT2 Proteine)-mediated phosphorylation of LAP2beta
LAP2alpha and BAF (zeige BANF1 Proteine) transiently localize to telomeres and specific regions on chromatin during nuclear assembly
A predicted Arg690Cys substitution within the LAP2 (zeige ERBB2IP Proteine) gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy.
Lamin (zeige LMNA Proteine)-associated polypeptide (LAP)2 beta assembles around only alternative oocyte chromatin after complete dephosphorylation of histone H3 (zeige HIST3H3 Proteine) following fertilization and activation. (lamina-associated polypeptide 2; LAP2beta)
Lifespan and body mass were increased in Lmna (zeige LMNA Proteine)(-/-)Lap2alpha(-/-) mice compared with Lmna (zeige LMNA Proteine) deficient mice.
Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (zeige LMNA Proteine) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (zeige LMNA Proteine) in the regulation of tissue progenitor cells are not affected in Lmna (zeige LMNA Proteine)(DeltaK32/DeltaK32) mice.
LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific (zeige EIF3K Proteine) gene expression during muscle regeneration, muscle remodeling and stress response.
TSLP (zeige TSLP Proteine) diverts airway tolerance against ovalbumin (zeige OVA Proteine) (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.
The age-related down-regulation of Wnt4 (zeige WNT4 Proteine) (and subsequently FoxN1 (zeige FOXN2 Proteine)), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.
Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.
Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 (zeige GATA4 Proteine) and MEF2c (zeige MEF2C Proteine), while dstrophin deficiency in Mdx (zeige DMD Proteine) mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.
In agreement with its regulation by E2F (zeige E2F1 Proteine), LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate
Loss of LAP2-Lmna (zeige LMNA Proteine) complexes causes erythroid and epidermal progenitor hyperproliferation.
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, lamina-associated polypeptide 2, isoform alpha-like
, TP beta
, Thymopoietin (lamina associated polypeptide 2)
, lamina-associated polypeptide 2
, thymopoietin isoform beta
, LEM domain containing 4
, TP alpha
, TP beta/gamma
, thymopoietin-related peptide isoform alpha
, thymopoietin-related peptide isoforms beta/gamma
, lamina associated polypeptide 2
, lamin-associated polypeptide 2beta
, thymopoietin II
, lamina-associated protein 2