Thromboxane A2 Receptor (TBXA2R) ELISA Kits

Rabbit Thromboxane A2 Receptor (TBXA2R) Interaktionspartner

1. Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.

Pig (Porcine) Thromboxane A2 Receptor (TBXA2R) Interaktionspartner

1. Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.

Human Thromboxane A2 Receptor (TBXA2R) Interaktionspartner

1. Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism

2. The tumour suppressors FOXP1 and NKX3.1, strongly implicated in PCa development, were identified as key transcription factors regulating TPbeta expression through Prm3 in both PCa cell lines.

3. The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPalpha receptor function has provided a powerful insight in defining the critical role of TPalpha in thrombus formation.

4. these data demonstrate that TPalpha/TPbeta can act as neoplastic and epigenetic regulators by mimicking and/or enhancing the actions of androgens within the prostate and provides further mechanistic insights into the role of the TXA2/TP signalling axis in prostate cancer, including potentially in CRPC.

5. Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae.

6. We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt-eNOS pathway.

7. data presented herein propose a novel diagnostic and prognostic potential for TPalpha and TPbeta in the histopathological assessment of PCa. While TPalpha and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha or both correlated with increased risk of recurrence and reduced disease-free survival time.

8. TBXA2R is a novel breast cancer-associated gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC).

9. TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.

10. We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 interaction and plays an important role in TPbeta maturation and cell-surface expression.

11. TBXA2R +924C/T polymorphism is associated with asthma risk

12. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms.

13. Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase pathway, up-regulation of cyclin B1/CDK1 expression, and down-regulation of apoptosis.

14. The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.

15. Which could be attenuated by treatment with a TP antagonist (PTXA2).

16. TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2

17. Data suggest TBXA2R requires Ser324 for normal activity; Ser324A mutant is insensitive to activation by protein kinase A/cell hypoxia, has high affinity for agonists (thromboxane A2/analogs), and participates in agonist-induced calcium mobilization.

18. There was no significant association between rs4523 variants and CI. However, there was a significant difference in the overall distribution of genotypes and dominant/recessive models of rs768963 between CI and control groups

19. TXA2 should be regarded as a critical molecule in COX-2-mediated tumor growth and a valuable target against lung cancer.

20. Human thromboxane A2 receptor genetic variant V80E exhibited reduced platelet activation whereas A160T demonstrated platelet hyperactivity.

Mouse (Murine) Thromboxane A2 Receptor (TBXA2R) Interaktionspartner

1. The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions.

2. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation

3. Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.

4. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.

5. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.

6. It is an active player in the pathogenesis of Alzheimer's disease.

7. Adhesion of platelets through thromboxane A receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.

8. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently.

9. Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein.

10. The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females.

11. We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.

12. thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury

13. Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells.

14. Genetic variations exist in this protein in platelet function disorders.

15. thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition

16. TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.

17. Thromboxane A2 (TXA2)-mediated platelet secretion and aggregation are important in thrombosis and the stable TXA2 analogue, U46619, induces two waves of platelet secretion, each of which precedes a distinct wave of platelet aggregation

18. Activation of TP receptors promotes T cell proliferation, and contributes to immune-mediated tissue injury.

19. Thromboxane A2 receptor has a role in the pathogenesis of angiotensin II-dependent hypertension.

20. TP -/- mice have a basal increase in renal vascular resistance and filtration fraction associated with reactive oxygen species.

Cow (Bovine) Thromboxane A2 Receptor (TBXA2R) Interaktionspartner

1. Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells.