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The protein encoded by THSD1 contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins.
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THSD1 forms a multimeric protein complex with FAK (zeige PTK2 ELISA Kits)/talin/vinculin (zeige VCL ELISA Kits), wherein THSD1 promotes talin binding to FAK (zeige PTK2 ELISA Kits) but not to vinculin (zeige VCL ELISA Kits), a key step in nascent adhesion assembly.
THSD1 mutation associated with Intracranial Aneurysm and Subarachnoid Hemorrhage.
The THSD1 gene may play a role in the tumorigenesis of colorectal cancer
Thrombospondin has a role in inducing RhoA (zeige RHOA ELISA Kits) inactivation through FAK (zeige PTK2 ELISA Kits)-dependent signaling to stimulate focal adhesion disassembly
The strong immunolocalization of thrombospondin (TSP (zeige THBS1 ELISA Kits)) in the outer anulus of the intervertebral disc indicates a role for TSP (zeige THBS1 ELISA Kits) in the avascular status of the adult human disc.
These findings suggest that THSD1 is a good candidate tumor suppressor gene.
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
thrombospondin type-1 domain-containing protein 1
, transmembrane molecule with thrombospondin module
, thrombospondin, type I, domain 1
, thrombospondin type I domain-containing 1