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The protein encoded by THSD1 contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Zusätzlich bieten wir Ihnen THSD1 Antikörper (63) und THSD1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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THSD1 forms a multimeric protein complex with FAK/talin/vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly.
THSD1 mutation associated with Intracranial Aneurysm and Subarachnoid Hemorrhage.
thrombospondin type I domain 1 is a new regulator of endothelial barrier function during vascular development and protects intraplaque microvessels against haemorrhaging in advanced atherosclerotic lesions
The THSD1 gene may play a role in the tumorigenesis of colorectal cancer
Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly
The strong immunolocalization of thrombospondin (TSP) in the outer anulus of the intervertebral disc indicates a role for TSP in the avascular status of the adult human disc.
These findings suggest that THSD1 is a good candidate tumor suppressor gene.
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
thrombospondin type-1 domain-containing protein 1
, transmembrane molecule with thrombospondin module
, thrombospondin, type I, domain 1
, thrombospondin type I domain-containing 1