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Study found that tetraspanin-1 was significantly higher in acute T cell-mediated rejection (TCMR) patients and could be detected in urine of kidney transplant recipients which makes it s potential diagnostic protein for TCMR.
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We conclude that TSPAN1 mediated apoptosis resistance of alveolar epithelial cells by regulating the NF-kappaB pathway. TSPAN1 may be a potential therapeutic target for pulmonary fibrosis or acute lung injury
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In accordance with the functional characteristics of the TSPAN superfamily, authors proved that TSPAN1 interacted with integrin alpha6beta1 to amplify the phosphoinositide-3-kinase (PI3K)/AKT/glycogen synthase kinase (GSK)-3beta/Snail family transcriptional repressor (Snail)/phosphatase and tensin homolog (PTEN) feedback loop.
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miR4913p is frequently downregulated in OS. miR4913p suppressed OS cell growth and invasion. TSPAN1 was identified to be a novel target of miR4913p. Overexpressed TSPAN1 conferred OS cell growth and invasion.
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TSPAN1 has a role in prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy
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The present study demonstrated that Tspan1 plays an important role in Pancreatic cancer carcinogenic progression, including migration and invasion.
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Restoration of TSPAN1 rescued the effects of miR-573 overexpression. Therefore, our findings suggest that the miR-573/TSPAN1 axis is important in the control of gastric carcinogenesis
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our current data demonstrate that miR-638 functions as a tumor suppressor in human colorectal carcinoma by inhibiting TSPAN1
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TSPAN1 was proved to induce migration, and so up-regulation of TSPAN1 by miR-200a may explain why over-expressing miR-200a promotes NSCLC cells migration
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these data argue against a role for tetraspanin 1 as a genuine mediator of cell surface receptor signalling but rather document a role for tetraspanin 1 in the control of cervical cancer cell motility and invasion.
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data suggest that the NET-1 gene may play an important role in proliferation, migration and endocytosis in the development and progress of hepatocellular carcinoma
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Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC.
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These studies demonstrate for the first time that Tspan-1 is an interacting partner with human thiamine transporter-1 and that this interaction affects thiamine transporter-1 stability.
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TSPAN1 may be another important breast cancer suppressor gene belonging to the tetraspanin superfamily.
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RNAi-mediated downregulation of TSPAN1 expression significantly inhibits the proliferation and invasion of colon cancer cells in vitro.
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The overexpression of Tspan-1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate.
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Data show that Tspan-1-EGFP expressed in ovarian carcinoma cells was detected mainly in lysosomes, but also in the plasma membrane and in the ER.
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Overexpression of NET-1 is associated with undifferentiated squamous cell carcinoma of cervical neoplasms
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Detection of NET-1 gene expression in liver biopsy may provide useful information about the biological behavior of hepatocellular carcinoma.
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Overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor.
