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May play a role in actin remodeling. Zusätzlich bieten wir Ihnen Tensin 3 Antikörper (24) und Tensin 3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes.
Tensin3 is a versatile regulator of DOCK5 signaling and cell adhesion. (Review)
Results indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone [tensin3].
Tns3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
Our work identifies Tns3 as a crucial focal adhesion component regulated by, and functionally contributing to, the switch between adhesive and non-adhesive states in MDA-MB-468 cancer cells.
A phosphorylation-mediated molecular switch comprising DLC), TNS3, PTEN and PI3K controls the spatiotemporal activation of Rac1 and RhoA, thereby initiating directional cell migration induced by growth factors.
The depletion of tensin-3 suppressed breast cancer cell invasiveness.
The phenotypic changes observed in proband cells may arise from TNS3 haploinsufficiency, causing partial loss of full-length Tensin3 protein. Tensin3 plays a rol in cytoskeletal organisation and cell motility.
These results reveal a differential methylation pattern in the TNS3 promoter occurring in human renal cell carcinoma.
Tensin3 may function as a platform for the disassembly of EGF-related signaling complexes at focal adhesions.
Data show that EGF downregulates tensin-3 expression, and concomitantly upregulates cten, a tensin family member that lacks the actin-binding domain.
TNS3-EXOC6B and EXOC6B-TNS3 fusion transcripts are detected in a premature male newborn with a complex multisystemic phenotype associated with a balanced translocation.
Tensin3 mRNA is expressed abundantly in all twelve functional adenomas at almost the same level as in normal thyroid tissue.
Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis.
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development.
, Temporarily Assigned Gene name family member (tag-163)-like
, tensin-like SH2 domain containing 1
, tensin-like SH2 domain-containing protein 1
, tumor endothelial marker 6
, tensin-like SH2 domain-containing 1
, thyroid specific PTB domain protein