TYRO Protein tyrosine Kinase Binding Protein Proteine (TYROBP)

TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. Zusätzlich bieten wir Ihnen TYROBP Antikörper (102) und TYROBP Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte TYROBP TYROBP 361537 Q6X9T7
TYROBP 7305 O43914
Maus TYROBP TYROBP 22177 O54885
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 bis 55 Tage
$7,493.38
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
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Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg 11 bis 18 Tage
$596.97
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TYROBP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,

Weitere Proteine zu TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaktionspartnern

Zebrafish TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaktionspartner

  1. The structure of the adaptor protein dap12 has been identified in the zebrafish genome.

  2. DAP12-based activating pathway is conserved between bony fish and mammals

Human TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaktionspartner

  1. High DAP12 expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

  2. Heterozygous carriership of the TYROBP deletion is not a major risk factor of cognitive impairment.

  3. Mutations in TYROBP are not a common cause of dementia in this Turkish cohort.

  4. Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 expression, a well-established risk factor for AD.

  5. TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  6. TYROBP/CSTA gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis

  7. The different expression of DAP12 compared to TREM2 represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.

  8. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation

  9. Impaired signaling by the TREM2-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.

  10. T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.

  11. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.

  12. isolated PMNs have an increased proportion of both TREM1 and DAP12 compared to normal healthy control

  13. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.

  14. Its mutation is a known genetic cause of Nasu-Hakola disease.

  15. Data indicate that NKG2 receptor NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum.

  16. Macrophage traits in BRC cells facilitate the metastatic process and DAP12 expression might promote metastatic homing to bone and liver tissues.

  17. DAP12 has a role in trafficking newly synthesized KIR to the cell surface. It interacts with an immature KIR2DS isoform likely initiating in the ER. DAP12also impacts KIR2DS surface stability.

  18. dynamics and dimerization of the TM helix of DAP12 in the membrane bilayer

  19. A molecular defect of DAP12 in human monocytes deregulates the gene network pivotal for maintenance of myeloid cell function in Nasu-Hakola disease.

  20. the putative periodontal pathogen P. gingivalis can positively regulate the expression of the TREM-1/DAP12 pathway in monocytic cells.

Mouse (Murine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaktionspartner

  1. High DAP12 expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

  2. Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)

  3. We identified modulatory effects of TYROBP deficiency on the level of phosphorylation of TAU that was accompanied by a reduction in the severity of neuritic dystrophy. TYROBP deficiency also altered the expression of several AD related genes, including Cd33. Electrophysiological abnormalities and learning behavior deficits associated with APP/PSEN1 transgenes were greatly attenuated on a Tyrobp-null background.

  4. These results demonstrate that PTX targets the innate immunity through DAP12, FcRgamma, and MyD88 providing new insights into the immunobiology of PTX.

  5. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12, both of which are expressed by microglia and have bee

  6. TNF/IL-6 generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12, and cell proliferation.

  7. The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.

  8. significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration

  9. DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death

  10. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.

  11. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

  12. DAP12 expression in liver grafts regulates donor mDC migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance

  13. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis.

  14. Our study identifies the DAP12/IRAK-M/IL-10 to be a novel molecular pathway in APCs exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

  15. We conclude that DAP12, partly through TREM1/3, is involved in renal inflammation during progression of unilateral ureter obstruction.

  16. Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL) signaling in association with DAP12.

  17. Dap12- and FcRgamma-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells.

  18. The effects of DAP12 deficiency on development of autoimmune uveitis are dramatically affected by environmental factors.

  19. DOK3 physically associated with the ITAM of DAP12 through its phosphotyrosine-binding domain. In response to LPS, DOK3 was phosphorylated in a DAP12- and Src-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.

  20. DAP12 is involved in microglia-induced dopaminergic neuron cell death in an in vitro model of Parkinson's disease.

Cow (Bovine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaktionspartner

  1. cloning, sequencing, and cell surface expression pattern

TYROBP Protein Überblick

Protein Überblick

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit TYROBP

  • TYRO protein tyrosine kinase binding protein (TYROBP)
  • TYRO protein tyrosine kinase binding protein (tyrobp)
  • Tyro protein tyrosine kinase binding protein (Tyrobp)
  • TYRO protein tyrosine kinase binding protein (Tyrobp)
  • dap12 Protein
  • KARAP Protein
  • Ly83 Protein
  • PLOSL Protein
  • TYROBP Protein
  • tyrpbp Protein

Bezeichner auf Proteinebene für TYROBP

TYRO protein tyrosine kinase-binding protein , TYRO protein tyrosine kinase binding protein , DAP12 protein , dap12 , DAP12 , DNAX-activation protein 12 , killer cell activating receptor-associated protein , KAR-associated protein , killer activating receptor associated protein , killer-activating receptor-associated protein , killer cell activating receptor associated protein , immunoreceptor DAP12 , tyrosine kinase binding protein

GENE ID SPEZIES
476477 Canis lupus familiaris
443208 Ovis aries
100101461 Danio rerio
361537 Rattus norvegicus
7305 Homo sapiens
22177 Mus musculus
282390 Bos taurus
397405 Sus scrofa
574207 Macaca mulatta
455968 Pan troglodytes
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