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TSC22D1 encodes a member of the TSC22 domain family of leucine zipper transcription factors.
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TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox (zeige COX8A Proteine) regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC (zeige CALR Proteine) patients
TSC-22 acts as a tumor suppressor by safeguarding p53 (zeige TP53 Proteine) from poly-ubiquitination mediated-degradation.
we report that induced Tsc-22 leads to enhancement of TGF-beta (zeige TGFB1 Proteine)-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant
Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene (zeige RAB1A Proteine)-induced cellular senescence.
Results support role of TSC22D1 as an enhancer of CNP (zeige CNP Proteine) transcription and suggest that TGF-beta (zeige TGFB1 Proteine)-induced upregulation of CNP (zeige CNP Proteine) expression in smooth muscle may be mediated in part by increased transcription of TSC22D1.
Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells
TSC-22 is an important downstream component of PPARgamma (zeige PPARG Proteine) and TGF-beta (zeige TGFB1 Proteine) signaling during intestinal epithelial cell differentiation
findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy
Upregulation of TSC-22 mRNA by TGF-beta 1 (zeige TGFB1 Proteine) is achieved by mRNA stabilization.
Tsc-22 modulates the TGF-beta (zeige TGFB1 Proteine)-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 (zeige SMAD3 Proteine) and Smad4 (zeige SMAD4 Proteine). It has effect on cellular differentiation
High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma.
These results suggested that TSC-22 could counteract the protective effect of GILZ (zeige TSC22D3 Proteine) on IL-2 (zeige IL2 Proteine)-deprivation-induced apoptosis.
Fat4 and Tsc22d1 are likely candidate genes to influence formation of spontaneous pulmonary adenoma in aging male and female mice, respectively.
post-transcriptional regulation of Tsc-22 mediated through Ybx1 (zeige YBX1 Proteine), a miR (zeige MLXIP Proteine)-216a target, plays a key role in TGF-beta (zeige TGFB1 Proteine)-induced Col1a2 (zeige COL1A2 Proteine) in MC related to the pathogenesis of diabetic nephropathy
novel opposing functions of the two mammalian TSC (zeige SLC12A3 Proteine)-22D1 isoforms in cell survival and proliferation, and establish the TSC (zeige SLC12A3 Proteine)-22D1 isoform 2 as a potential regulator of cell death during mammary gland involution
Analysis of the regulation of Tgf beta1i4 by Foxc1 (zeige FOXC1 Proteine) in mesenchymal cells isolated from the periocular region revealed that Foxc1 (zeige FOXC1 Proteine) negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1 (zeige TGFB1 Proteine).
TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.
XTSC-22 (TSC-22) is required for cell movement during gastrulation though cell cycle regulation.
Analysis of deletion mutants of XTSC-22 revealed that nuclear localization of the N-terminal TSC (zeige TESC Proteine)-box is necessary for cell cycle inhibition by XTSC-22.
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
TGFB-stimulated clone 22 homolog
, TGFbeta-stimulated clone 22
, TSC22 domain family protein 1
, cerebral protein 2
, regulatory protein TSC-22
, transcriptional regulator TSC-22
, transforming growth factor beta-1-induced transcript 4 protein
, transforming growth factor beta-stimulated protein TSC-22
, Tgfb-stimulated clone 22 homolog
, Tsc22-related inducible leucine zipper 1b
, regulatory protein Tsc22
, transforming growth factor beta 1 induced transcript 4
, Transforming growth factor beta stimulated clone 22
, TSC22 domain family, member 1
, short tandem repeat locus PEZ20 variant 19
, TGFb stimulated clone 22 (TSC-22)
, TSC22 domain family 1