TIMP Metallopeptidase Inhibitor 1 Proteine (TIMP1)

TIMP1 belongs to the TIMP gene family. Zusätzlich bieten wir Ihnen TIMP1 Antikörper (299) und TIMP1 Kits (148) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032
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Top TIMP1 Proteine auf antikoerper-online.de

Showing 10 out of 61 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
HEK-293 Cells Human His tag 10 μg 2 bis 3 Tage
$235.00
Details
Human Cells Human His tag 10 μg 14 bis 16 Tage
$233.59
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Human Cells Maus Unkonjugiert 10 μg 14 bis 16 Tage
$311.24
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Human Cells Ratte Unkonjugiert 10 μg 14 bis 16 Tage
$311.24
Details
HEK-293 Cells Maus His tag Validation with Western Blot 10 μg 4 bis 8 Tage
$352.00
Details
HEK-293 Cells Human His tag Validation with Western Blot 10 μg 4 bis 8 Tage
$352.00
Details
Human Human Unkonjugiert 10 μg 6 bis 7 Tage
$474.41
Details
Human Cells Human His tag   50 μg 4 Days
$522.50
Details

TIMP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
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Rat (Rattus) , ,

Mouse (Murine) , , , ,
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Weitere Proteine zu TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartnern

Human TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Imbalance in the metalloproteinase (MMP2, MMP9) to inhibitor tissue expression (TIMP1, TIMP2) in the vessel wall (the cross-sections of the internal thoracic artery, radial artery, and saphenous vein) might predispose to aortocoronary graft failure after coronary artery bypass grafting. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.

  2. Elevated MMP-1 and reduced TIMP-1 were found in obstructed defecation syndrome associated with internal rectal prolapse

  3. High serum Level of TIMP1 is associated with large bowel adenoma.

  4. TIMP-1 plays a negative regulatory role in the proliferation and osteogenesis of hBMSCs, at least partially, through Wnt/beta-catenin signaling.

  5. imbalance between MMP-9 and TIMP-1 could play an important role in metastatic spread via lymphatic pathways of head and neck squamous cell carcinoma cells

  6. Low density lipoprotein (-) induced the release of MMP-9 and TIMP-1 in monocytes through CD14.

  7. The versatile impact of TIMP-1 on cellular functions stems from its two-domain structure harboring metalloproteinase-inhibitory and cytokine-like signaling activities.

  8. Data demonstrate significantly higher serum concentrations of inflammatory biomarkers MMP-8, MPO and TIMP-1 in acute ischemic stroke cases.

  9. our findings demonstrate overexpression of TIMP1 in mouse and human gastric cancers through NF-kB-dependent mechanism. We also show that TFF1 suppresses NF-kappaB and inhibits TIMP1-mediated proliferative potential in gastric cancer.

  10. TIMP-1 expression exhibits an upper moderate diagnostic value in CRC

  11. Serum levels of TIMP-1 were identified as a clinically useful marker for distinguishing NAFLD patients with and without significant fibrosis.

  12. Comparatively lower expression of MMP-7 in gastric mucosal inflammation and imbalanced expression of TIMP-1 might be two of the pathogeneses of chronic stomach disease

  13. Findings indicated that IL-32gamma suppressed skin carcinogenesis through the inhibition of both stemness and the inflammatory tumor microenvironment by the downregulation of TIMP-1 and ITGAV via inactivation of NF-kappaB signaling.

  14. we have shown that deleterious variation in TIMP3 is associated with bicuspid aortic valve and indices of thoracic aortic aneurysm. We further found that there is a synergistic interaction between loss of the X chromosome gene, TIMP1, and deleterious variation in TIMP3 that significantly increases that risk.

  15. MMP-8 and TIMP-1 in serum, but not MMP-9, identified colorectal cancer patients with bad prognosis

  16. Moreover, the shift in the TIMP-1/ MMP-1 ratio identifies increased synthesis of TIMP-1 as one of the processes associated with collagen I overproduction in HGF fibroblasts.

  17. TGF-beta1 appears to promote CAD through the induction of cell apoptosis by upregulating SPHK1 expression and further upregulating its downstream TIMP-1.

  18. significantly increased in the serum of type 2 diabetes mellitus patients with diabetic retinopathy

  19. Study evaluated for the first time the plasma levels and the diagnostic usefulness of VEGF, MMP-9, and TIMP-1 in cervical cancer (CC), not only independently but especially in combination with established cervical tumor markers. All tested parameters showed statistical significance when compared their concentrations in patients with CC to healthy women.

  20. In monocytes, incubation with psoriasis' sera increased the production of MMP-9 and TIMP-1 in comparison with both baseline and monocytes incubated with non-psoriatic sera

Cow (Bovine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  5. Identification, purification and partial characterization of bovine pulmonary artery smooth muscle tissue inhibitor of matrix metalloproteinase-1

  6. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Pig (Porcine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.

  2. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.

  3. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.

  4. Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD.

Rabbit TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. There were clear time-dependent degenerative changes in the histology of the medial meniscus after PCL rupture. The high expression of TIMP-1, MMP-1 and MMP-13 in the cartilage may be responsible for the degeneration, and PCL rupture may trigger meniscus degradation and ultimately osteoarthritis

  2. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 1 (TIMP1) Interaktionspartner

  1. The data suggest that Timp1 promotes the immune response in the lungs after influenza infection facilitating an injurious phenotype as a result of influenza infection.

  2. the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status.

  3. conclude that the intrinsic dynamics of TIMP-1 are not involved in its binding to LRP-1 but rather in the initiation of endocytosis and associated biological effects.

  4. Study implicated TIMP1, released from the vasculature, as a mediator of the tumorpromoting effects of endothelial PECAM1, thus suggesting its potential role in the progression of metastatic tumors.

  5. miR-138 and ER stress were induced in osteoporosis and then promoted the apoptosis of osteoblasts, at least in part, through TIMP-1.

  6. TIMP-1 is upregulated in liver fibrosis and hepatocellular carcinoma, potentially implying diagnostic relevance in the non-invasive assessment of liver fibrosis or in HCC detection6. However, our study in TIMP-1-deficient mice did not confirm a functional role of TIMP-1 in the development of liver fibrosis or hepatocellular carcinoma.

  7. In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 and TGF-beta1 at transcriptional and translational levels

  8. gingival fibroblasts cell-based therapy is a promising approach to inhibit aneurysm progression and rupture through local production of Timp-1

  9. These results show that MMP-9/TIMP-1 system disturbance and changes of histological structure in uteri tissue are involved in fluoride-induced reproductive dysfunctions.

  10. Tissue inhibitor of matrix metalloproteinases 1 (TIMP1) inhibition resensitized tumors to gemcitabine and radiotherapy.

  11. proteomic analysis of the mesenchymal stem cells secretome identified the TIMP-1 as a potential effector molecule responsible for the anti-angiogenic properties of MSC

  12. TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  13. This study highlights a previously undescribed integral role for TIMP1 in both vascular network maturation and adaptations to ischemia or alterations in flow.

  14. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  15. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  16. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63.

  17. TIMP-1 is a ligand of LRP-1 and we highlight a new example of its MMP-independent, cytokine-like functions.

  18. RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.

  19. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2/MMP-9 system, and PDGF-D signaling is mediated through both PDGF-alpha and -beta receptors.

  20. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK signaling pathway.

TIMP1 Protein Überblick

Protein Überblick

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Genbezeichner und Symbole assoziert mit TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1)
  • TIMP metallopeptidase inhibitor 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (Timp1)
  • Clgi Protein
  • DKFZp468A0912 Protein
  • EPA Protein
  • EPO Protein
  • HCI Protein
  • Timp Protein
  • TIMP-1 Protein
  • TIMP1 Protein

Bezeichner auf Proteinebene für TIMP1

tissue inhibitor of matrix metalloproteinase-1 , TIMP metallopeptidase inhibitor 1 , Metalloproteinase inhibitor 1 , TIMP-1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinases 1 , EG-1 , embryogenin-1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metallopeptidase 1 , tissue inhibitor of metalloproteinase 1 , metalloproteinase tissue inhibitor , metalloproteinase tissue inhibitor 1 , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

GENE ID SPEZIES
574348 Macaca mulatta
100172253 Pongo abelii
7076 Homo sapiens
282092 Bos taurus
116510 Rattus norvegicus
101686851 Mustela putorius furo
443331 Ovis aries
396862 Sus scrofa
403816 Canis lupus familiaris
100009047 Oryctolagus cuniculus
21857 Mus musculus
100034220 Equus caballus
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