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The product encoded by TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. Zusätzlich bieten wir Ihnen TIA1 Antikörper (119) und viele weitere Produktgruppen zu diesem Protein an.
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Tia1 controls p53 (zeige TP53 Proteine) mRNA translation in B cells.
TIA1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 induces tau misfolding and stimulates neurodegeneration.
This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.
Genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain, similar to the fasting effect.
TIA proteins can function as long-term regulators of the ACTB (zeige ACTB Proteine) mRNA metabolism in mouse and human cells.
TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.
Either TIA1 or TIAR (zeige TIAL1 Proteine) inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.
TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo.
Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2 (zeige PTGS2 Proteine)) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.
TIA-1 and TTP (zeige ZFP36 Proteine) are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines
Downregulation of TIA-1-enhanced mitochondrial elongation, whereas ectopic expression of TIA-1 resulted in mitochondria fragmentation. In addition, TIA-1 increased mitochondrial activity, including the rate of ATP synthesis and oxygen consumption.
findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis
studied a novel Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS (zeige IGFALS Proteine)/FTD (zeige FTL Proteine)) family and identified the P362L mutation in the low-complexity domain (LCD) of TIA1; genetic association analyses showed an increased burden of TIA1 LCD mutations in ALS (zeige IGFALS Proteine) patients compared to controls; TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition
Here we designed UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 (zeige RRM2 Proteine) and RRM3 and demonstrated that the TIA-1 RRM23 construct preferentially binds the UC-rich RNA ligand. Together our data support a specific mode of TIA-1 RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 in binding RNA to regulate gene expression
miR (zeige MLXIP Proteine)-19a could promote cell proliferation and migration in CRC (zeige CALR Proteine) cells and accelerated tumor growth in xenograft mice by targeting TIA1.
Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein (zeige TIAL1 Proteine)) contribute to mRNA stability as cis (zeige CISH Proteine)-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1 (zeige PCBP1 Proteine), and RBM39 (zeige RBM39 Proteine) stabilizes or increases U2 snRNP (zeige LSM2 Proteine) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39 (zeige RBM39 Proteine)-mediated splicing regulation.
AT1R (zeige AGTR1 Proteine) mRNA is regulated by TIA-1 in a ER stress-dependent manner.
SERPINE1 (zeige SERPINE1 Proteine) mRNA dissociates from the translational repressor proteins Ago2 (zeige EIF2C2 Proteine) and TIA-1 upon platelet activation
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
nucleolysin TIA-1 isoform p40
, nucleolysin tia-1
, nucleolysin TIA-1
, TIA1 cytotoxic granule-associated RNA binding protein
, Nucleolysin TIA-1
, RNA-binding protein TIA-1
, T-cell-restricted intracellular antigen-1
, cytotoxic granule-associated RNA-binding protein 1
, p40-TIA-1 (containing p15-TIA-1)
, TIA1 cytotoxic granule-associated RNA binding protein-like 1
, nucleolysin TIAR
, cytotoxic granule-associated RNA binding protein 1