THO Complex 4 Proteine (THOC4)

The protein encoded by THOC4 is a heat stable, nuclear protein and functions as a molecular chaperone. Zusätzlich bieten wir Ihnen THO Complex 4 Antikörper (78) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
THOC4 10189 Q86V81
THOC4 21681 O08583
Ratte THOC4 THOC4 690585  
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag,Strep Tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process THO Complex 4 (THOC) (AA 2- 257), fraction 15 - 16 1 mg 30 bis 35 Tage
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Hefe REACT_Zebra finch His tag   1 mg 60 bis 71 Tage
Hefe Rind (Kuh) His tag   1 mg 60 bis 71 Tage
Hefe Xenopus laevis His tag   1 mg 60 bis 71 Tage
Hefe Xenopus tropicalis His tag   1 mg 60 bis 71 Tage

THOC4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu THO Complex 4 (THOC4) Interaktionspartnern

Human THO Complex 4 (THOC4) Interaktionspartner

  1. In both ORF57 and ICP27 the interaction sites for ALYREF and UIF partially overlap, suggestive of mutually exclusive binding. The data provide a map of the binding sites responsible for promoting herpes virus mRNA export, enabling future studies to accurately probe these interactions and reveal the functional consequences for UIF and ALYREF redundancy

  2. Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2.

  3. ALYREF mainly binds to the 5' and the 3' regions of the mRNA. ALYREF is likely recruited to mRNAs by PABPN1 and the 3' processing machinery.

  4. The competition between hMTR4 and ALYREF determines exosome recruitment and functions in creating balanced nuclear RNA pools for degradation and export.

  5. small hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT-HDAg-L(198-210), containing the 10-amino acid TAT peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion.

  6. A short conserved motif in ALYREF directs cap- and exon junction complex-dependent assembly of export complexes on spliced mRNAs.

  7. the data provides the first site-specific description of how viral mRNA is locked by a herpes viral adaptor protein in complex with cellular ALYREF, giving herpesvirus access to the cellular mRNA export machinery

  8. a spatial map is produced in living cells of the sites for the interaction of two TREX subunits, Alyref and Chtop, with Nxf1.

  9. ALY is a novel E2F2-interacting protein and a relevant modulator of E2F-responsive gene expression.

  10. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.

  11. High ALY expression is associated with lymph node metastasis in oral squamous cell carcinoma.

  12. Authors propose that Aly, THO and UAP56 form a highly integrated unit to associate with the spliced mRNA and function in mRNA export.

  13. REF/Aly-ORF57 interaction is not essential for KSHV lytic replication but may contribute to target RNA stability independent of effects on RNA export, suggesting a novel role for REF/Aly in viral RNA metabolism.

  14. When the TREX components UAP56 or Aly are knocked down, spliced mRNA, as well as total polyA+ RNA, accumulates in nuclear speckle domains.

  15. A differential connection between tumorogenesis and the expression levels of human THO and ALY.

  16. Results describe the subcellular localization of ICP27 and its colocalization with cellular RNA export factors Aly/REF and TAP/NXF1.

  17. recruitment of the human TREX complex to spliced mRNA is not directly coupled to transcription, but is instead coupled to transcription indirectly through splicing

  18. suggest a central role for ALY in T-cell enhancer function and oncogene activation

  19. Increased TAP binding correlates with increased SF2/ASF binding, but not increased REF/Aly or Y14 binding.

  20. Aly is a physiological target of nuclear PI3K signaling, which regulates its subnuclear residency, cell proliferation, and mRNA export activities through nuclear Akt phosphorylation and phosphoinositide association.

Mouse (Murine) THO Complex 4 (THOC4) Interaktionspartner

  1. Structure of the nuclear factor ALY provides insights into post-transcriptional regulatory and mRNA nuclear export processes.

THO Complex 4 (THOC4) Protein Überblick

Protein Überblick

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.

Genbezeichner und Symbole assoziert mit THO Complex 4 Proteine (THOC4)

  • Aly/REF export factor (ALYREF)
  • THO complex 4 (Thoc4)
  • Aly/REF export factor (alyref)
  • Aly/REF export factor L homeolog (alyref.L)
  • Aly/REF export factor (Alyref)
  • ALY Protein
  • ALY/REF Protein
  • alyref-a Protein
  • BEF Protein
  • REF Protein
  • REF1 Protein
  • Refbp1 Protein
  • Tho4 Protein
  • Tho4-A Protein
  • Thoc4 Protein
  • thoc4-a Protein
  • zgc:171753 Protein

Bezeichner auf Proteinebene für THO Complex 4 Proteine (THOC4)

THO complex 4 , THO complex subunit 4 , ally of AML-1 and LEF-1 , bZIP enhancing factor , bZIP-enhancing factor BEF , tho4 , transcriptional coactivator Aly/REF , THO complex subunit 4-A , aly/REF export factor-A , REF1-I , RNA and export factor binding protein 1 , RNA and export factor-binding protein 1 , Tcra enhancer-binding factor interacting protein 1 , aly/REF export factor , putative disulfide-isomerase

744649 Pan troglodytes
100170121 Nasonia vitripennis
10189 Homo sapiens
560127 Danio rerio
734364 Xenopus laevis
769169 Gallus gallus
21681 Mus musculus
690585 Rattus norvegicus
100190053 Taeniopygia guttata
537706 Bos taurus
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