TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa Proteine (TAF15)

TAF15 encodes a member of the TET family of RNA-binding proteins. Zusätzlich bieten wir Ihnen TAF15 Antikörper (86) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus TAF15 TAF15 70439  
Ratte TAF15 TAF15 287571  
TAF15 8148 Q92804
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage

TAF15 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,

Weitere Proteine zu TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15) Interaktionspartnern

Mouse (Murine) TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15) Interaktionspartner

  1. FUS and TAF15 exhibit similar global RNA interaction profiles in vivo, but affect a strikingly small subset of common genes. Unexpectedly, TAF15 influences a small fraction of amyotrophic lateral sclerosis events compared with TDP-43 and FUS in the mouse CNS.

  2. TAF15 is required for a critical alternative splicing event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate receptor (Grin1) that controls the activity and trafficking of NR1.

Human TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa (TAF15) Interaktionspartner

  1. Results find that the Asp residue in TAF15 YGGDR(S/G)G repeats confers poor binding to PRMT1 indicating that YGGDR(S/G)G repeats may contribute to TAF15 specialization by enabling differential interactions with PRMT1 and reduced overall levels of TAF15 methylation compared with other FET proteins.

  2. weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation.

  3. In human stem cell-derived motor neurons, the RNA profile associated with concomitant loss of both TAF15 and FUS resembles that observed in the presence of the amyotrophic lateral sclerosis (ALS)-associated mutation FUS R521G, but contrasts with late-stage sporadic ALS patients.

  4. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.

  5. Aggregation of FET proteins FUS, EWSR1, and TAF15 mediate a pathological change in amyotrophic lateral sclerosis. (Review)

  6. Studies provide evidence that FUS/TLS, EWS and TAF15 proteins play a major role in neurodegenerative disorders. (review).

  7. O-GlcNAc glycosylation stoichiometry of TAF15

  8. RNA binding by TAF-15 is dependent upon structural elements in the RNA rather than sequence.

  9. our data suggest that TAF15 and TLS/FUS operate within similar but not identical hnRNP M-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type.

  10. Data indicate that distinct differences in proteins becoming Poly(ADP-ribose) PARylated upon various genotoxic insults are observed, exemplified by the PARylation of RNA-processing factors THRAP3 and TAF15 under oxidative stress.

  11. TAF15 depletion inhibits growth & increases apoptosis. Its knockdown affects many genes involved in cell cycle & cell death. Among these, targets of microRNAs generated from the onco-miR-17 locus were overrepresented.

  12. Data show that FUS and TAF15 locate to cellular stress granules to a larger extend than EWS. FET-protein stress granule association most likely is a downstream response to cellular stress.

  13. The existence of a functionally discrete subset of U1 snRNP in association with TAF15 was suggested and provided further support for the involvement of U1 snRNP components in early steps of coordinated gene expression.

  14. TAF15 plays a role in RNA transport and/or local RNA translation

  15. Missense mutations of TAF-15, an RNA-binding protein, were found in patients with amyotrophic lateral sclerosis, and gene conferred neurodegeneration when expressend in Drosophila.

  16. REsults suggest the possibility that alterations of TAF15 and EWS might also be involved in the pathogenesis of FUS proteinopathies such as ALS and FTLD.

  17. Rare translocation t(12;17)(p13;q12), this translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases.

  18. These results suggest that additional studies are needed to determine whether mutations in the TAF15 gene represent a cause of familial amyotrophic lateral sclerosis.

  19. Elevated TAF15 mRNA levels did not translate to strongly elevated protein levels, consistent with its infrequent occurrence as translocation partner in tumors.

  20. Our findings define a role for a tumor-specific TAF15 antigen in malignant processes.

TAF15 Protein Überblick

Protein Überblick

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit TAF15

  • TATA-box binding protein associated factor 15 (Taf15)
  • TATA-box binding protein associated factor 15 (TAF15)
  • 68kDa Protein
  • 2610111C21Rik Protein
  • Npl3 Protein
  • RBP56 Protein
  • TAF2N Protein
  • TAFII68 Protein

Bezeichner auf Proteinebene für TAF15

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa , TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56) , TATA-binding protein-associated factor 2N , RBP56/CSMF fusion , TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56) , TATA box-binding protein-associated factor 2N (RNA-binding protein 56) , TBP-associated factor 15

70439 Mus musculus
287571 Rattus norvegicus
8148 Homo sapiens
417522 Gallus gallus
536067 Bos taurus
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