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TLX1 encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. Zusätzlich bieten wir Ihnen TLX1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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TLX1-dependent regulation of retinoic acid metabolism is critical for spleen organogenesis.
Loss of Hox11 function leads to fracture repair defects, including reduced cartilage formation and delayed ossification.
Tlx1(CreER-Venus) mice represent a new tool for lineage tracing and conditional gene manipulation of spleen mesenchymal cells during morphogenesis.
Hox11 genes are expressed in the connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of the zeugopod region throughout all stages of development.
Tlx1/3 and Ptf1a (zeige PTF1A Antikörper), the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord
Results demonstrate that the transcriptional activity of HOX11 is regulated by phosphorylation of Thr247 in a cell cycle-specific manner and that this phosphorylation modulates the expression of the target gene, cyclin B1 (zeige CCNB1 Antikörper).
Hox11 paralogous genes regulate wrist and ankle joint organization and are essential for establishing carpal and tarsal element boundary and maintaining their articulating surface tissue.
Seven conserved Cdx (zeige CDX1 Antikörper) binding sites were found in the Hoxa 11 (zeige HOXA11 Antikörper) promoter, suggesting regulatory sites.
dysregulated expression of a particular set of downstream target genes by DNA binding via the homeodomain is of central importance for leukemia initiation mediated by HOX11 homeodomain protein
results have shown that the Hox10 (zeige VSX2 Antikörper) and Hox11 paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements
TLX1 hypermethylation is associated with colorectal cancer.
The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.
these results place TLX1 and TLX3 (zeige TLX3 Antikörper) at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 (zeige RUNX1 Antikörper) as a tumor-suppressor gene in T-ALL
The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 (zeige TLX3 Antikörper) is due to binding of TLX1/TLX3 (zeige TLX3 Antikörper) to ETS1 (zeige ETS1 Antikörper).
Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression.
conclude that the TLX1/NOTCH (zeige NOTCH1 Antikörper)/MYC (zeige MYC Antikörper) network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH (zeige NOTCH1 Antikörper)/MYC (zeige MYC Antikörper) transcriptional network coregulates genes involved in T cell development
Transgenic expression of human TLX1 in mice induces T cell acute lymphoblastic leukemia with frequent deletions and mutations in Bcl11b (zeige BCL11B Antikörper).
co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.
A PBX2 (zeige PBX2 Antikörper) Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells.
Detrmination site by nested polymerase chain reaction the integration sites in TLX1-immortalized hematopoietic cell lines.
identification and expression patterns of three members of the zebrafish Tlx (zeige NR2E1 Antikörper) family
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
T-cell leukemia homeobox protein 1
, T-cell leukemia, homeobox 1
, homeobox TLX-1
, homeobox protein Hox-11
, T-cell leukemia/lymphoma protein 3
, homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
, proto-oncogene TCL-3
, homeobox protein 11