T-Box 20 Proteine (TBX20)

TBX20 encodes a T-box family member. Zusätzlich bieten wir Ihnen TBX20 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TBX20 57057 Q9UMR3
TBX20 57246 Q9ES03
Ratte TBX20 TBX20 315497  
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Top TBX20 Proteine auf antikoerper-online.de

Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,232.17
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,232.17
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,234.00
Details
Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,250.50
Details

TBX20 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu T-Box 20 (TBX20) Interaktionspartnern

Zebrafish T-Box 20 (TBX20) Interaktionspartner

  1. Tbx20 activity needs to be tightly fine-tuned to guarantee regular cardiomyocyte proliferation and embryonic heart growth in vivo.

  2. the identification of a zebrafish tbx20 mutation that results in an inactive, truncated protein lacking any functional domains, is reported.

  3. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20, and has2 in the heart

  4. embryos lacking hrT function have dysmorphic hearts and an absence of blood circulation

  5. redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis, but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 and tbx20 through the maturation stage

Xenopus laevis T-Box 20 (TBX20) Interaktionspartner

  1. we show that TBX5 and TBX20 can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 20 (TBX20) Interaktionspartner

  1. TBX20 can be considered a KCNH2-modifying gene.

  2. This study firstly links TBX20 loss-of-function mutation to familial tetralogy of Fallot or sporadic persistent truncus arteriosus, providing novel insight into the molecular pathogenesis of Congenital heart disease.

  3. results showed that the TBX20 gene is not the major gene affecting nonsyndromic congenital heart disease development

  4. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)

  5. chromatin analysis reveals that endocardial TBX20 has roles in septation

  6. The current study associated TBX20 haploinefficiency with isolated Dilated cardiomyopathy (DCM), and expanded upon the mutational spectrum of TBX20 associated with DCM and congenital heart disease (CHD), which provides novel insight into the molecular mechanism of DCM and CHD, suggesting potential implications for early personalized treatment of these diseases.

  7. Silencing of TBX20 in rat myocardial and human embryonic kidney cells significantly inhibited cell proliferation, induced cell apoptosis and led to G2/M cell cycle arrest.

  8. rs3999950 may be associated with congenital heart disease, and TBX20 may predispose children to the defect.

  9. Among the 8 SNPs identified, 6 are in strong linkage disequilibrium and the minor alleles are associated with lower CHD risk. The minor alleles have lower transcriptional activity than major alleles in both human heart tissues and three cell lines. TBX20 minor alleles may exhibit higher binding affinity with certain transcription repressors.

  10. Cardiac TBX20 expression showed a negative correlation with LVEF and a positive correlation with left ventricular end-systolic volume. No significant difference in TBX20 CNVs and promoter methylation was observed between IDCM patients and control group

  11. The mutation markedly reduced the synergistic activation of TBX20 with NKX2-5 or GATA4.

  12. We report three missense mutations (Y309D, T370O, and M395R) within the transcriptional activator domain of human TBX20 that were associated with atrial septal defect

  13. Data showed that the TC genotype of SNP rs3999941 and AC genotype of the new SNP c.657A>C in the TBX20 gene may be risk factors for CHD.

  14. TBX20 loss-of-function mutation contributes to double outlet right ventricle

  15. A novel TBX20 mutation, c.526G>A (p.D176N), was identified and co-segregated in all affected members in this family of three generations with atrial septal defects.

  16. Tbx20 regulated PPAR-gamma expression and protected the vascular endothelial cells from oxidized low-density lipoprotein -induced injury.

  17. Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress.

  18. Study identified one novel heterozygous sequence variant within the proximal promoter region of TBX20 gene in a ventricular septal defects patient, which inhibited transcriptional activities of TBX20 gene promoter; data provide new information to help understanding of genetic causes and molecular mechanisms of congenital heart disease.

  19. This novel interaction between TBX20b and MKLN1 may help elucidate new regulatory mechanisms within heart development.

  20. Found tertiary hydrophobic interactions within the mutant TBX20 T-box of Ostium secundum atrial septal defect subjects were significantly altered leading to a more dynamic structure of the protein.

Mouse (Murine) T-Box 20 (TBX20) Interaktionspartner

  1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM)

  2. chromatin analysis reveals that endocardial TBX20 has roles in septation

  3. Tbx18 does not function redundantly with Tbx2 or Tbx20 in epicardial development.

  4. Cardiomyocyte Tbx20 induced overexpression activates multiple cardiac proliferative pathways, directly represses cell-cycle inhibitory genes p21, Meis1, and Btg2, promotes adult CM proliferation; and preserves cardiac performance after MI.

  5. TLE1/TLE3-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.

  6. The effects of Tbx20 are epistatic to Tbx3 in the heart, but Tbx3 is epistatic to Tbx20 with respect to developmental delay.

  7. Tbx20-mediated increases in cell proliferation, providing evidence for parallel regulatory pathways downstream of BMP/Smad1/5/8 signaling in promoting cardiomyocyte proliferation after birth

  8. Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development. Ablation of Tbx20 in endocardial cells causes severe valve elongation defects and impaired cardiac function.

  9. a dual role for TBX20 as both a transcriptional activator and a repressor, and that each of these functions regulates genes with very specialized and distinct molecular roles

  10. Data show distinct functions for Tbx20 in regulation of cardiomyocyte lineage maturation and cell proliferation at embryonic and fetal stages of heart development.

  11. Genome-wide ChIP analysis of Tbx20-binding regions in the adult heart revealed that many of these genes were direct downstream targets of Tbx20 and uncovered a previously undescribed DNA-binding site for Tbx20.

  12. mice lacking Tbx20 in the atrioventricular canal myocardium fail to form the atrioventricular canal constriction, and the endocardial epithelial-mesenchymal transition (EMT) is severely perturbed.

  13. the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation.

  14. data demonstrate clear differences in both the expression and function of Tbx5 and Tbx20 and suggest that the modulation of cardiac gene expression can occur as a result of combinatorial regulatory interactions of T-box proteins

  15. Tbx20 represses Tbx2 in chamber myocardium, preventing repression of Nmyc1 and resulting in relatively high proliferation in the developing heart.

  16. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.

  17. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.

  18. Tbx20 may ensure progression to a multi-chambered heart by repressing Tbx2 in the myocardial precursor cells of the linear heart tube destined to form the chambers

  19. Study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway.

  20. These data highlight unique features of Tbx20 and suggest mechanistic ways in which cardiac T-box factors might interact synergistically and/or competitively within the cardiac regulatory network.

TBX20 Protein Überblick

Protein Überblick

This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit T-Box 20 Proteine (TBX20)

  • T-box 20 (TBX20)
  • T-box 20 (tbx20)
  • Tbx20-like homeobox protein (tbx20)
  • T-box 20 L homeolog (tbx20.L)
  • T-box 20 (Tbx20)
  • 9430010M06Rik Protein
  • AL022859 Protein
  • ASD4 Protein
  • cb826 Protein
  • hrt Protein
  • Tbx12 Protein
  • tbx20 Protein
  • tbx20-A Protein
  • XTBX20 Protein
  • ZF-TBX20 Protein

Bezeichner auf Proteinebene für T-Box 20 Proteine (TBX20)

T-box 20 , T-box transcription factor 20 , Tbx20-like homeobox protein , H15-related T-box transcription factor hrT , T-box protein 20 , T-box transcription factor TBX20 , cTbx20

GENE ID SPEZIES
467053 Pan troglodytes
619590 Xenopus (Silurana) tropicalis
100070390 Equus caballus
100225521 Taeniopygia guttata
100303555 Saccoglossus kowalevskii
57936 Danio rerio
378656 Xenopus laevis
373943 Gallus gallus
57057 Homo sapiens
539419 Bos taurus
57246 Mus musculus
315497 Rattus norvegicus
482396 Canis lupus familiaris
Ausgewählte Anbieter für TBX20 Proteine (TBX20)
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