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The protein encoded by SDCBP was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. Zusätzlich bieten wir Ihnen SDCBP Antikörper (144) und SDCBP Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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Studied role of melanoma differentiation associated protein-9 (MDA-9)/Syntenin in autophagy of anoikis-resistant glioma stem cells.
Frizzled 7 and phosphatidylinositol 4,5-diphosphate binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signaling.
Syntenin mediates SRC (zeige SRC Proteine) function in exosomal cell-to-cell communication.
These findings demonstrate that syntenin promotes VEGF (zeige VEGFA Proteine) signaling and, through its PDZ-dependent interaction with ephrin-B2 (zeige EFNB2 Proteine), enhances VEGF (zeige VEGFA Proteine)-mediated VEGFR2 (zeige KDR Proteine) endocytosis and subsequent downstream signaling and angiogenesis in endothelial cells
Syntenin-1 promotes invasion and progression of squamous cell carcinomas of the head and neck.
MDA-9 upregulated active levels of known modulators of epithelial mesenchymal transformation, the small GTPases RhoA (zeige RHOA Proteine) and Cdc42 (zeige CDC42 Proteine), via TGFbeta1 (zeige TGFB1 Proteine), promoting lung metastasis of breast cancer cells.
a unique function of MDA-9 as a facilitator and determinant of glioma stemness and survival.
SDCBP might be an important marker for identifying Triple negative breast cancer cases that are suitable for dasatinib therapy.
ACTB (zeige ACTB Proteine), CDKN1B (zeige CDKN1B Proteine), GAPDH (zeige GAPDH Proteine), GRB2 (zeige GRB2 Proteine), RHOA (zeige RHOA Proteine) and SDCBP are potent reference genes in neuroendocrine tumors of the lung.
In summary, the study identifies miR (zeige MLXIP Proteine)-216b as a regulator of SDCBP expression in breast cancer which can potentially be targeted for developing newer therapies for the effective treatment of this killer disease.
Present study is the first demonstration of the relevance of MDA-9/Syntenin expression in regulating inflammation and immunosuppression in the microenvironment thereby impacting tumor growth and metastasis in mouse melanoma model.
Syntenin-1 negatively regulates the intestinal immunoglobulin production and has a function to maintain the intestinal homeostasis in vivo.
ALCAM (zeige ALCAM Proteine) stably interacts with actin by binding to syntenin-1 and ezrin (zeige EZR Proteine).
Angiopoietin-2 (zeige ANGPT2 Proteine) secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt (zeige AKT1 Proteine)/endothelial nitric oxide synthase (eNOS (zeige NOS3 Proteine)) and syndecan-4 (zeige SDC4 Proteine)/syntenin pathways.
MDA-9/syntenin may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation through modulating multiple signaling pathways as a crucial adaptor protein.
Complex of Unc51.1 (zeige ULK1 Proteine)/SynGAP1 (zeige SYNGAP1 Proteine)/Syntenin governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5 (zeige RAB5A Proteine)-mediated endocytic pathways within developing axons
Syntenin-1 may function as a scaffolding protein coupling CD6 (zeige CD6 Proteine) and other lymphocyte receptors to cytoskeleton and/or signaling effectors during immunologic synapse maturation
syntenin plays a role in the migration of oligodendroglial precursors, and we suggest that NG2 (zeige Vcan Proteine)-syntenin-1 interactions contribute to this
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
melanoma differentiation associated protein-9
, melanoma differentiation-associated protein 9
, pro-TGF-alpha cytoplasmic domain-interacting protein 18
, scaffold protein Pbp1
, syndecan-binding protein 1
, syndecan interacting protein
, syndecan binding protein